Search Results - "Benito, José M."

Immune checkpoint inhibitors as potential therapy for reverting T-cell exhaustion and reverting HIV latency in people living with HIV by Benito, José M, Restrepo, Clara, García-Foncillas, Jesús, Rallón, Norma

“…The immune system of people living with HIV (PLWH) is persistently exposed to antigens leading to systemic inflammation despite combination antiretroviral…”
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Expression of PD-1 and Tim-3 markers of T-cell exhaustion is associated with CD4 dynamics during the course of untreated and treated HIV infection by Rallón, Norma, García, Marcial, García-Samaniego, Javier, Cabello, Alfonso, Álvarez, Beatriz, Restrepo, Clara, Nistal, Sara, Górgolas, Miguel, Benito, José M

“…T-cell exhaustion has been involved in the pathogenesis of HIV infection. We have longitudinally analyzed PD1 and Tim3 surrogate markers of T-cells exhaustion,…”
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Formulation and Preparation of Water-In-Oil-In-Water Emulsions Loaded with a Phenolic-Rich Inner Aqueous Phase by Application of High Energy Emulsification Methods by Niknam, Seyed Mehdi, Escudero, Isabel, Benito, José M.

“…Currently, industry is requesting proven techniques that allow the use of encapsulated polyphenols, rather than free molecules, to improve their stability and…”
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Separation of sodium lactate from Span 80 and SDS surfactants by ultrafiltration by Roque, Lara, Escudero, Isabel, Benito, José M.

“…•Lactic acid back-extraction was performed by breakup of niosomes at pH>12.•Sodium lactate separation from Span 80 and SDS reached using UF ceramic…”
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Elite controllers: A heterogeneous group of HIV-infected patients by Navarrete-Muñoz, María A., Restrepo, Clara, Benito, José M., Rallón, Norma

“…The exceptional group of ECs has been of great help, and will continue to provide invaluable insight with regard to reach a potential functional cure of HIV…”
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HCV coinfection contributes to HIV pathogenesis by increasing immune exhaustion in CD8 T-cells by Rallón, Norma, García, Marcial, García-Samaniego, Javier, Rodríguez, Noelia, Cabello, Alfonso, Restrepo, Clara, Álvarez, Beatriz, García, Rosa, Górgolas, Miguel, Benito, José M

“…There are several contributors to HIV-pathogenesis or insufficient control of the infection. However, whether HIV/HCV-coinfected population exhibits worst…”
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Peering into the HIV reservoir by García, Marcial, Buzón, María J., Benito, José M., Rallón, Norma

“…Summary The main obstacle to HIV eradication is the establishment of a long‐term persistent HIV reservoir. Although several therapeutic approaches have been…”
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Treatment of a waste oil-in-water emulsion from a copper-rolling process by ultrafiltration and vacuum evaporation by Gutiérrez, Gemma, Lobo, Alberto, Benito, José M., Coca, José, Pazos, Carmen

“…A process is proposed for the treatment of a waste oil-in-water (O/W) emulsion generated in an industrial copper-rolling operation. The use of demulsifier…”
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HIV-reservoir size is not affected either by HCV coinfection or by direct acting antivirals (DAAs) therapy by Álvarez, Beatriz, Navarrete-Muñoz, María A., Briz, Veronica, Olmedillas-López, Susana, Nistal, Sara, Cabello, Alfonso, Prieto, Laura, Górgolas, Miguel, García-Arranz, Mariano, Benito, José M., Rallón, Norma

“…The role of HCV on the HIV reservoir is controversial since the reduction on HIV-DNA levels after HCV eradication with IFNα/RBV treatment seems to be the…”
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A specific natural killer cells phenotypic signature associated to long term elite control of HIV infection by Rallón, Norma, Jiménez‐Carretero, Daniel, Restrepo, Clara, Ligos, José M., Valentín‐Quiroga, Jaime, Mahillo, Ignacio, Cabello, Alfonso, López‐Collazo, Eduardo, Sánchez‐Cabo, Fátima, Górgolas, Miguel, Estrada, Vicente, Benito, José M.

“…Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) that control HIV replication without therapy. Among the mechanisms involved…”
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Neutrophil β1 adrenoceptor blockade blunts stroke‐associated neuroinflammation by Clemente‐Moragón, Agustín, Oliver, Eduardo, Calle, Daniel, Cussó, Lorena, Gómez, Mónica, Pradillo, Jesús M., Castejón, Raquel, Rallón, Norma, Benito, José M., Fernández‐Ferro, José C., Carneado‐Ruíz, Joaquín, Moro, María A., Sánchez‐González, Javier, Fuster, Valentín, Cortés‐Canteli, Marta, Desco, Manuel, Ibáñez, Borja

“…Background and Purpose Reperfusion therapy is the standard of care for ischaemic stroke; however, there is a need to identify new therapeutic targets able to…”
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Preparation of Water-in-Oil Nanoemulsions Loaded with Phenolic-Rich Olive Cake Extract Using Response Surface Methodology Approach by Niknam, Seyed Mehdi, Kashaninejad, Mansoore, Escudero, Isabel, Sanz, María Teresa, Beltrán, Sagrario, Benito, José M

“…In this study, we aimed to prepare stable water-in-oil (W/O) nanoemulsions loaded with a phenolic-rich aqueous phase from olive cake extract by applying the…”
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High frequency of CD8 escape mutations in elite controllers as new obstacle for HIV cure by Navarrete-Muñoz, María A., Ramos, Ricardo, Holguín, África, Cabello, Alfonso, Górgolas, Miguel, Benito, José M., Rallón, Norma

“…Accumulation of mutations in epitopes of cytolytic-T-lymphocytes immune response (CTL) in HIV-reservoir seems to be one of the reasons for shock-and-kill…”
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IL7RA rs10491434 polymorphism is related to spontaneous HIV infection control in naïve HIV‐infected patients: A retrospective study by Sepúlveda‐Crespo, Daniel, Jiménez‐Sousa, María A., Fernández‐Rodíguez, Amanda, Muñoz‐Fernández, María A., Jiménez, José L., Caraciolo, Begoña B., Reus Bañuls, Sergio, Vilchez, Helem, Mothe, Beatriz, Martínez, Isidoro, Benito, José M., Rallón, Norma, Resino, Salvador

“…Interleukin 7 receptor (IL7R) is vital in the adaptive immune response against human immunodeficiency viruses (HIV). We assessed IL7RA polymorphisms (SNPs) in…”
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IRF5‐TNOP3 polymorphisms are associated with elite control of HIV infection: A retrospective study by Sepúlveda‐Crespo, Daniel, Jiménez‐Sousa, María A., Fernández‐Rodíguez, Amanda, Muñoz‐Fernández, María A., Jiménez, José Luis, Moreno, Santiago, Garcia, Felipe, Martínez, Isidoro, Benito, José M., Rallón, Norma, Resino, Salvador

“…IRF5–TNPO3 polymorphisms have previously been related to immune response, and TNPO3 plays a role in human immunodeficiency virus (HIV)‐1 infection after…”
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High Plasma sTNF-R1 Level Is Related to Loss of Natural HIV Control in Long-Term Elite Controllers by Sepúlveda-Crespo, Daniel, Rallón, Norma, Muñoz-Gómez, María José, Brochado-Kith, Oscar, Jiménez, José Luis, Muñoz-Fernández, María Ángeles, Benito, José M, Resino, Salvador

“…Human immunodeficiency virus-1 (HIV-1) elite controllers are heterogeneous due to different immunovirological features. We aimed to identify plasma biomarkers…”
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A Knockout IFNL4 Variant Is Associated With Protection From Sexually Transmitted HIV-1 Infection by Jaimes-Bernal, Claudia, Rallón, Norma, Benito, José M, Omar, Mohamed, Gómez-Vidal, María Amparo, Márquez, Francisco José, Sánchez-Arcas, Beatriz, Trujillo, Monte, Royo, José Luis, Saulle, Irma, Biasin, Mara, Rivero-Juárez, Antonio, Caruz, Antonio

“…Abstract An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α–dependent cure of hepatitis C virus…”
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DBP rs7041 and DHCR7 rs3829251 are Linked to CD4 + Recovery in HIV Patients on Antiretroviral Therapy by Resino, Salvador, Jiménez-Sousa, María Ángeles, Blanco, Julià, Pacheco, Yolanda M, Del Romero, Jorge, Peraire, Joaquim, Virseda-Berdices, Ana, Muñoz-Gómez, María José, Galera-Peñaranda, Carlos, García-Fraile, Lucio Jesus, Benito, José M, Rallón, Norma

“…The lack of the recovery of CD4 T-cells (CD4 recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known…”
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A high mucosal blocking score is associated with HIV protection by Girard, Alexandre, Rallón, Norma, Benito, José M, Jospin, Fabienne, Rodriguez, Carmen, Chanut, Blandine, Benjelloun, Fahd, Del Romero, Jorge, Verrier, Bernard, Lucht, Frédéric, Pin, Jean-Jacques, Genin, Christian, Biasin, Mara, Clerici, Mario, Paul, Stéphane

“…BACKGROUND:Early steps of HIV infection are mediated by the binding of the envelope to mucosal receptors as α4β7 and the C-type lectins DC-SIGN and langerin…”
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Transcriptional signature of resting-memory CD4 T cells differentiates spontaneous from treatment-induced HIV control by García, Marcial, López-Fernández, Luis, Mínguez, Pablo, Morón-López, Sara, Restrepo, Clara, Navarrete-Muñoz, María A, López-Bernaldo, Juan Carlos, Benguría, Alberto, García, María Isabel, Cabello, Alfonso, Fernández-Guerrero, Manuel, De la Hera, Francisco Javier, Estrada, Vicente, Barros, Carlos, Martínez-Picado, Javier, Górgolas, Miguel, Benito, José M., Rallón, Norma

“…The HIV reservoir is the main barrier to eradicating HIV infection, and resting memory CD4 T (Trm) cells are one of the most relevant cellular component…”
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