HIV type 1 pol gene diversity and genotypic antiretroviral drug resistance mutations in Malabo, Equatorial Guinea

In this study, HIV strains circulating among military personnel were characterized, in Malabo, the capital city of Equatorial Guinea. One sample was found to be HIV-2 group A while a high degree of genetic diversity was recorded in the pol region of 41 HIV-1-positive samples. CRF02_AG accounted for...

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Bibliographic Details
Published in:	AIDS research and human retroviruses Vol. 26; no. 9; p. 1027
Main Authors:	Djoko, Cyrille F, Wolfe, Nathan D, Vidal, Nicole, Tamoufe, Ubald, Montavon, Celine, LeBreton, Matthew, Pike, Brian L, Fair, Joseph, Mbacham, Wilfred F, Benito, Alogos, Rimoin, Anne W, Saylors, Karen, Mpoudi-Ngole, Eitel, Grillo, Michael P, Peeters, Martine
Format:	Journal Article
Language:	English
Published:	United States 01-09-2010
Subjects:	Adolescent Adult Anti-HIV Agents - therapeutic use Drug Resistance, Viral - genetics Equatorial Guinea Female HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics Humans Male Middle Aged Military Personnel Molecular Sequence Data Phylogeny pol Gene Products, Human Immunodeficiency Virus - genetics Recombination, Genetic Sequence Analysis, Protein Young Adult Equatorial Guinea
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Summary:	In this study, HIV strains circulating among military personnel were characterized, in Malabo, the capital city of Equatorial Guinea. One sample was found to be HIV-2 group A while a high degree of genetic diversity was recorded in the pol region of 41 HIV-1-positive samples. CRF02_AG accounted for 53.7% of the strains, and 11 different variants were obtained in the remaining 19 samples: subtype G (n = 3), A3 (n = 2), C (n = 2), CRF26_A5U (n = 2), F2 (n = 1), CRF06 (n = 1), CRF09 (n = 1), CRF11 (n = 1), CRF22 (n = 1), and divergent subtype A (n = 1) and F (n = 1). One strain could not be classified and three were unique recombinants. Analysis of antiretroviral drug resistance mutations revealed two patients each harboring one major mutation, M46I in protease and D67N in reverse transcriptase sequences, respectively. The high genetic diversity and emerging ARV resistance mutations call for frequent surveys and appropriate monitoring of ARV considering the increasing access to ARV in the country.
ISSN:	1931-8405
DOI:	10.1089/aid.2010.0046