Search Results - "Beninger, Richard J."

Post learning sleep improves cognitive-emotional decision-making: evidence for a 'deck B sleep effect' in the Iowa Gambling Task by Seeley, Corrine J, Beninger, Richard J, Smith, Carlyle T

“…The Iowa Gambling Task (IGT) is widely used to assess real life decision-making impairment in a wide variety of clinical populations. Our study evaluated how…”
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Post-weaning social isolation and subchronic NMDA glutamate receptor blockade: Effects on locomotor activity and GABA signaling in the rat suggest independent mechanisms by Hickey, Andrea J., Reynolds, James N., Beninger, Richard J.

“…Animal models of schizophrenia symptoms include administration of noncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonists, such as MK-801,…”
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Inhibition of glycogen synthase kinase-3 by SB 216763 affects acquisition at lower doses than expression of amphetamine-conditioned place preference in rats by Wickens, Rebekah H, Quartarone, Susan E, Beninger, Richard J

“…Dopamine (DA) drives incentive learning, whereby neutral stimuli acquire the ability to elicit responses. DA influences the signaling molecule glycogen…”
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Increased drinking following social isolation rearing: implications for polydipsia associated with schizophrenia by Hawken, Emily R, Delva, Nicholas J, Beninger, Richard J

“…Primary polydipsia, excessive drinking without known medical cause, is especially associated with a diagnosis of schizophrenia. We used animal models of…”
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Lifespan Changes in the Countermanding Performance of Young and Middle Aged Adult Rats by Beuk, Jonathan, Beninger, Richard J, Paré, Martin

“…Inhibitory control can be investigated with the countermanding task, which requires subjects to make a response to a go signal and cancel that response when a…”
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Obsessive-compulsive disorder: Insights from animal models by Szechtman, Henry, Ahmari, Susanne E., Beninger, Richard J., Eilam, David, Harvey, Brian H., Edemann-Callesen, Henriette, Winter, Christine

“…•Utility of animal models in research on OCD is considered and insights gained reviewed.•Optogenetic studies in mice demonstrate that hyperactivity in CBGTC…”
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Typical and atypical antipsychotic medications differentially affect two nondeclarative memory tasks in schizophrenic patients: a double dissociation by Beninger, Richard J., Wasserman, James, Zanibbi, Katherine, Charbonneau, Danielle, Mangels, Jennifer, Beninger, Bruce V.

“…Nondeclarative memory (NDM) has subtypes associated with different brain regions; learning of a probabilistic classification task is impaired by striatal…”
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Paradoxical effects of the opioid antagonist naltrexone on morphine analgesia, tolerance, and reward in rats by Powell, Kelly J, Abul-Husn, Noura S, Jhamandas, Asha, Olmstead, Mary C, Beninger, Richard J, Jhamandas, Khem

“…Opioid agonists such as morphine have been found to exert excitatory and inhibitory receptor-mediated effects at low and high doses, respectively. Ultra-low…”
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Neonatal ventral hippocampal lesions in male and female rats: Effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood by Beninger, Richard J., Tuerke, Katharine J., Forsyth, Jennifer K., Giles, Andrew, Xue, Lihua, Boegman, Roland J., Jhamandas, Khem

“…Schizophrenia is characterized by diverse behavioural and neurochemical abnormalities that may be differentially expressed in males and females. Male rats with…”
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Inhibition of Wnt signalling dose-dependently impairs the acquisition and expression of amphetamine-induced conditioned place preference by Islam, Farhana, Xu, Kathleen, Beninger, Richard J.

“…•Wnt inhibitor, IWP-2, was microinjected into the NAc of rats.•Intra-NAc IWP-2 blocked the acquisition and expression of amphetamine-induced CPP.•Acquisition…”
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The amphetamine sensitization model of schizophrenia symptoms and its effect on schedule-induced polydipsia in the rat by Hawken, Emily R., Beninger, Richard J.

“…Rationale Amphetamine enhances dopamine (DA) transmission and induces psychotic states or exacerbates psychosis in at-risk individuals. Amphetamine…”
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Intra-accumbens protein kinase C inhibitor NPC 15437 blocks amphetamine-produced conditioned place preference in rats by Aujla, Harinder, Beninger, Richard J.

“…In a previous study, intracerebroventricular calcium-dependent protein kinase (PKC) inhibition attenuated cocaine place conditioning. This suggested the…”
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Contextual response time adaptation in the countermanding performance of rats by Beuk, Jonathan, Beninger, Richard J, Mechefske, Elysia, Paré, Martin

“…Highlights • Rat response time was significantly longer in sessions including stop trials. • Responses were significantly longer following errors in…”
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Ventromedial Prefrontal Theta Activity During Rapid Eye Movement Sleep is Associated With Improved Decision-Making on the Iowa Gambling Task by Seeley, Corrine J., Smith, Carlyle T., MacDonald, Kevin J., Beninger, Richard J.

“…Recent research is beginning to reveal an intricate relationship between sleep and decision-making. The Iowa Gambling Task (IGT) is a unique decision-making…”
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cAMP-dependent protein kinase and reward-related learning: intra-accumbens Rp-cAMPS blocks amphetamine-produced place conditioning in rats by BENINGER, Richard J, NAKONECHNY, Patricia L, SAVINA, Ioulia

“…Dopamine may produce reward-related learning by activating D(1)-like receptors in the nucleus accumbens (NAc) and stimulating the formation of cyclic adenosine…”
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The effect of quetiapine (Seroquel™) on conditioned place preference and elevated plus maze tests in rats when administered alone and in combination with (+)-amphetamine by McLelland, Angela E., Martin-Iverson, Mathew T., Beninger, Richard J.

“…Rationale Recent case reports describe recreational use of quetiapine and drug-seeking behaviour to obtain quetiapine, an atypical antipsychotic. Objective We…”
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A response strategy predicts acquisition of schedule-induced polydipsia in rats by Gregory, James Gardner, Hawken, Emily R., Banasikowski, Tomek J., Dumont, Eric C., Beninger, Richard J.

“…Schedule-induced polydipsia (SIP) is excessive, non-regulatory drinking. We aimed to identify phenotypic learning traits representative of neural circuitry…”
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Schizophrenic patients treated with clozapine or olanzapine perform better on theory of mind tasks than those treated with risperidone or typical antipsychotic medications by Savina, Ioulia, Beninger, Richard J

“…Abstract Theory of mind (ToM), the ability to attribute mental states to others, is associated with medial prefrontal cortical (mPFC) activity and is impaired…”
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Spiroperidol, but not eticlopride or aripiprazole, produces gradual increases in descent latencies in the bar test in rats by Rocca, Jeffery F, Lister, Joshua G, Beninger, Richard J

“…Rats repeatedly exposed to the bar test following injections with a dopamine D2-like receptor antagonist such as haloperidol show increased descent latencies,…”
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Differential effects of clozapine, metoclopramide, haloperidol and risperidone on acquisition and performance of operant responding in rats by Baker, Tyson W., Florczynski, Matthew M., Beninger, Richard J.

“…Rationale Prior research has not systematically investigated the effects of systemic antipsychotic drugs on operant response acquisition, specifically their…”
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