Search Results - "Benie, Andrew J"

Fragment-based Screening of the Donor Substrate Specificity of Human Blood Group B Galactosyltransferase Using Saturation Transfer Difference NMR by Blume, Astrid, Angulo, Jesus, Biet, Thorsten, Peters, Hannelore, Benie, Andrew J., Palcic, Monica, Peters, Thomas

“…Saturation transfer difference NMR experiments on human blood group B α-(1,3)-galactosyltransferase (GTB) for the first time provide a comprehensive set of…”
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NMR analysis of carbohydrate-protein interactions by Angulo, Jesus, Rademacher, Christoph, Biet, Thorsten, Benie, Andrew J, Blume, Astrid, Peters, Hannelore, Palcic, Monica, Parra, Francisco, Peters, Thomas

“…Carbohydrate-protein interactions are frequently characterized by dissociation constants in the microM to mM range. This is normally associated with fast…”
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Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis by Sickmann, Helle M, Waagepetersen, Helle S, Schousboe, Arne, Benie, Andrew J, Bouman, Stephan D

“…Obesity and type 2 diabetes have reached epidemic proportions; however, scarce information about how these metabolic syndromes influence brain energy and…”
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A diversity optimized combinatorial library for the identification of Fc-fragment binding ligands by Nielsen, Anders L., Jørgensen, Flemming S., Olsen, Lars, Christensen, Søren F., Benie, Andrew J., Bjørnholm, Thomas, St. Hilaire, Phaedria M.

“…To generate a library covering a relatively wide area of the chemical space, molecular descriptors, and multivariate data analysis were combined to select the…”
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Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin by Hjorth, Christian Fogt, Norrman, Mathias, Wahlund, Per-Olof, Benie, Andrew J, Petersen, Bent O, Jessen, Christian M, Pedersen, Thomas Å, Vestergaard, Kirsten, Steensgaard, Dorte B, Pedersen, Jan Skov, Naver, Helle, Hubálek, František, Poulsen, Christian, Otzen, Daniel

“…A specific covalently linked dimeric species of insulin high molecular weight products (HMWPs), formed during prolonged incubation of a neutral pharmaceutical…”
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Hepatitis A virus proteinase 3C binding to viral RNA: correlation with substrate binding and enzyme dimerization by Peters, Hannelore, Kusov, Yuri Y, Meyer, Sonja, Benie, Andrew J, Bäuml, Englbert, Wolff, Maike, Rademacher, Christoph, Peters, Thomas, Gauss-Müller, Verena

“…Proteinase 3C of hepatitis A virus (HAV) plays a key role in the viral life cycle by generating mature viral proteins from the precursor polyprotein. In…”
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Saturation transfer difference NMR and computational modeling of a sialoadhesin–sialyl lactose complex by Bhunia, Anirban, Jayalakshmi, V., Benie, Andrew J., Schuster, Oliver, Kelm, Sørge, Rama Krishna, N., Peters, Thomas

“…Graphic The siglecs are a family of I-type lectins binding to sialic acids on the cell surface. Sialoadhesin (siglec-1) is expressed at much higher levels in…”
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Normal Neurodevelopment and Fertility in Juvenile Male Rats Exposed to Polyethylene Glycol Following Dosing With PEGylated rFIX (Nonacog Beta Pegol, N9-GP): Evidence from a 10-Week Repeat-Dose Toxicity Study by Jensen, Vivi F. H., Schefe, Line H., Jacobsen, Helene, Mølck, Anne-Marie, Almholt, Kasper, Sjögren, Ingrid, Dalsgaard, Charlotte M., Kirk, Rikke K, Benie, Andrew J., Petersen, Bent O., Kyhn, Mette S., Overgaard, Anne J., Bjørnsdottir, Inga, Stannard, Diane R., Offenberg, Hanne K., Egecioglu, Emil

“…N9-GP/Rebinyn®/Refixia® is an approved PEGylated (polyethylene glycol-conjugated) recombinant human factor IX intended for prophylactic and/or on-demand…”
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Functional binding of hexanucleotides to 3C protease of hepatitis A virus by Blaum, Bärbel S, Wünsche, Winfried, Benie, Andrew J, Kusov, Yuri, Peters, Hannelore, Gauss-Müller, Verena, Peters, Thomas, Sczakiel, Georg

“…Oligonucleotides as short as 6 nt in length have been shown to bind specifically and tightly to proteins and affect their biological function. Yet, sparse…”
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Characterization of Ligand Binding to N-Acetylglucosamine Kinase Studied by STD NMR by Blume, Astrid, Berger, Markus, Benie, Andrew J., Peters, Thomas, Hinderlich, Stephan

“…Saturation transfer difference (STD) NMR experiments on human N-acetylglucosamine kinase (GlcNAc kinase) have been used to determine binding epitopes for the…”
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HAT HMBC: A hybrid of H2BC and HMBC overcoming shortcomings of both by Benie, Andrew J., Sørensen, Ole W.

“…A new 2D NMR experiment, HAT HMBC, that is a hybrid of H2BC and HMBC aims at establishing two-bond correlations absent in H2BC spectra because of vanishing 3 J…”
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Specificity of ligand binding to yeast hexokinase PII studied by STD-NMR by Blume, Astrid, Fitzen, Michael, Benie, Andrew J., Peters, Thomas

“…Hexokinase catalyzes the phosphorylation of glucose and is the first enzyme in glycolysis. To investigate enzyme–ligand interactions in yeast hexokinase…”
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Consistent Bioactive Conformation of the Neu5Acα(2[rightward arrow]3)Gal Epitope Upon Lectin Binding by Bhunia, Anirban, Schwardt, Oliver, Gäthje, Heiko, Gao, Gan-Pan, Kelm, Soerge, Benie, Andrew J, Hricovini, Milos, Peters, Thomas, Ernst, Beat

“…Get to NOE MAG: Partial structures of GQ1bα, the natural ligand of the myelin‐associated glycoprotein (MAG), have been synthesized and subjected to NOE…”
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Consistent bioactive conformation of the Neu5Acalpha(2-->3)Gal epitope upon lectin binding by Bhunia, Anirban, Schwardt, Oliver, Gäthje, Heiko, Gao, Gan-Pan, Kelm, Soerge, Benie, Andrew J, Hricovini, Milos, Peters, Thomas, Ernst, Beat

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Virus−Ligand Interactions:  Identification and Characterization of Ligand Binding by NMR Spectroscopy by Benie, Andrew J, Moser, Rosita, Bäuml, Englbert, Blaas, Dieter, Peters, Thomas

“…We demonstrate the detection and characterization of ligand binding to viruses via NMR. To illustrate the methodology, the interaction of an antiviral compound…”
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Adiabatic Low-Pass J Filters for Artifact Suppression in Heteronuclear NMR by Meier, Sebastian, Benie, Andrew J., Duus, Jens Ø., Sørensen, Ole W.

“…NMR artifact purging: Modern NMR experiments depend on efficient coherence transfer pathways for their sensitivity and on suppression of undesired pathways…”
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Improved multiplicity-editing of HMBC NMR spectra by Benie, Andrew J., Sørensen, Ole W.

“…A new improved multiplicity‐edited HMBC experiment is introduced that leads to better J cross‐talk suppression in the even (i.e. C + CH2 groups) and odd (i.e…”
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3D H2BC: A novel experiment for small-molecule and biomolecular NMR at natural isotopic abundance by Meier, Sebastian, Benie, Andrew J., Duus, Jens Ø., Sørensen, Ole W.

“…3D H2BC is introduced for heteronuclear assignment on natural abundance samples even for biomolecules up to at least 10 kDa in low millimolar concentrations as…”
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Characterization of ligand binding to the bifunctional key enzyme in the sialic acid biosynthesis by NMR: II. Investigation of the ManNAc kinase functionality by Benie, Andrew J, Blume, Astrid, Schmidt, Richard R, Reutter, Werner, Hinderlich, Stephan, Peters, Thomas

“…N-Acetylmannosamine (ManNAc) is the physiological precursors to all sialic acids that occur in nature. As variations in the sialic acid decoration of cell…”
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New methods for calibration of the RF field strength for indirectly observed nuclei by Benie, Andrew J., Sørensen, Ole W.

“…Two novel pulse sequences, CALIS-1 and CALIS-2, for accurate calibration of the RF field strength for an indirectly observed spin are introduced. CALIS-2 is…”
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