Search Results - "Bengoa‐Vergniory, Nora"

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model by Roberts, Bradley M., Doig, Natalie M., Brimblecombe, Katherine R., Lopes, Emanuel F., Siddorn, Ruth E., Threlfell, Sarah, Connor-Robson, Natalie, Bengoa-Vergniory, Nora, Pasternack, Nicholas, Wade-Martins, Richard, Magill, Peter J., Cragg, Stephanie J.

“…Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release is under tonic inhibition by striatal GABA. Ambient striatal GABA…”
Get full text

LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies by Emmenegger, Marc, De Cecco, Elena, Hruska‐Plochan, Marian, Eninger, Timo, Schneider, Matthias M, Barth, Melanie, Tantardini, Elena, de Rossi, Pierre, Bacioglu, Mehtap, Langston, Rebekah G, Kaganovich, Alice, Bengoa‐Vergniory, Nora, Gonzalez‐Guerra, Andrès, Avar, Merve, Heinzer, Daniel, Reimann, Regina, Häsler, Lisa M, Herling, Therese W, Matharu, Naunehal S, Landeck, Natalie, Luk, Kelvin, Melki, Ronald, Kahle, Philipp J, Hornemann, Simone, Knowles, Tuomas P J, Cookson, Mark R, Polymenidou, Magdalini, Jucker, Mathias, Aguzzi, Adriano

“…While the initial pathology of Parkinson’s disease and other α‐synucleinopathies is often confined to circumscribed brain regions, it can spread and…”
Get full text

A Switch From Canonical to Noncanonical Wnt Signaling Mediates Early Differentiation of Human Neural Stem Cells by Bengoa‐Vergniory, Nora, Gorroño‐Etxebarria, Irantzu, González-Salazar, Itxaso, Kypta, Robert M.

“…Wnt/β‐catenin signaling is essential for neurogenesis but less is known about β‐catenin‐independent Wnt signals. We show here that Wnt/activator protein‐1…”
Get full text

Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease by Fields, Carroll Rutherford, Bengoa-Vergniory, Nora, Wade-Martins, Richard

“…Parkinson's disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has…”
Get full text

Canonical and noncanonical Wnt signaling in neural stem/progenitor cells by Bengoa-Vergniory, Nora, Kypta, Robert M.

Get full text

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease by Bengoa-Vergniory, Nora, Faggiani, Emilie, Ramos-Gonzalez, Paula, Kirkiz, Ecem, Connor-Robson, Natalie, Brown, Liam V., Siddique, Ibrar, Li, Zizheng, Vingill, Siv, Cioroch, Milena, Cavaliere, Fabio, Threlfell, Sarah, Roberts, Bradley, Schrader, Thomas, Klärner, Frank-Gerrit, Cragg, Stephanie, Dehay, Benjamin, Bitan, Gal, Matute, Carlos, Bezard, Erwan, Wade-Martins, Richard

“…Parkinson’s disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers…”
Get full text

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior by Hunn, Benjamin H.M., Vingill, Siv, Threlfell, Sarah, Alegre-Abarrategui, Javier, Magdelyns, Morgane, Deltheil, Thierry, Bengoa-Vergniory, Nora, Oliver, Peter L., Cioroch, Milena, Doig, Natalie M., Bannerman, David M., Cragg, Stephanie J., Wade-Martins, Richard

“…Parkinson’s disease (PD) is characterized by the death of dopamine neurons in the substantia nigra pars compacta (SNc) and accumulation of α-synuclein…”
Get full text

Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles by Doucet, Marika, El-Turabi, Aadil, Zabel, Franziska, Hunn, Benjamin H M, Bengoa-Vergniory, Nora, Cioroch, Milena, Ramm, Mauricio, Smith, Amy M, Gomes, Ariane Cruz, Cabral de Miranda, Gustavo, Wade-Martins, Richard, Bachmann, Martin F

“…Parkinson's disease (PD) is a progressive and currently incurable neurological disorder characterised by the loss of midbrain dopaminergic neurons and the…”
Get full text

CO-CULTURE OF Α-SYNUCLEIN-TREATED IPSC-DERIVED DOPAMINERGIC NEURONS AND MICROGLIA AS AN IN VITRO MODEL OF PARKINSON’S DISEASE by Villegas-Zafra, Patricia, Olano-Bringas, Jon, Ciceri, Dalila, Kurt, Begum, Bengoa-Vergniory, Nora

Get full text

EXPLORING A NEUROPROTECTIVE ROLE FOR REST IN PARKINSON’S DISEASE IN VIVO by Ciceri, Dalila, Kurt, Begum, Villegas-Zafra, Patricia, Olano-Bringas, Jon, Bengoa-Vergniory, Nora

Get full text

MOLECULAR AND MORPHOLOGICAL CHANGES IN OLIGODENDROCYTE LINEAGE CELLS IN PARKINSON’S DISEASE IN VIVO by Kurt, Begum, Ciceri, Dalila, Olano-Bringas, Jon, Villegas-Zafra, Patricia, Bengoa-Vergniory, Nora

Get full text

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease by Bengoa-Vergniory, Nora, Velentza-Almpani, Elisavet, Silva, Ana Maria, Scott, Connor, Vargas-Caballero, Mariana, Sastre, Magdalena, Wade-Martins, Richard, Alegre-Abarrategui, Javier

“…Multimerization is a key process in prion-like disorders such as Alzheimer's disease (AD), since it is a requirement for self-templating tau and beta-amyloid…”
Get full text

Identification of Noncanonical Wnt Receptors Required for Wnt-3a-Induced Early Differentiation of Human Neural Stem Cells by Bengoa-Vergniory, Nora, Gorroño-Etxebarria, Irantzu, López-Sánchez, Inmaculada, Marra, Michele, Di Chiaro, Pierluigi, Kypta, Robert

“…Wnt proteins preferentially activate either β-catenin-dependent or β-catenin-independent signals, but the activity of a particular Wnt also depends on cellular…”
Get full text

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol by Threlfell, Sarah, Mohammadi, Amir Saeid, Ryan, Brent J, Connor-Robson, Natalie, Platt, Nicola J, Anand, Rishi, Serres, Florence, Sharp, Trevor, Bengoa-Vergniory, Nora, Wade-Martins, Richard, Ewing, Andrew, Cragg, Stephanie J, Brimblecombe, Katherine R

“…Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson's disease (PD). DATs can…”
Get full text

Distinct expression and activity of GSK-3α and GSK-3β in prostate cancer by Darrington, R. Siobhan, Campa, Victor M., Walker, Marjorie M., Bengoa-Vergniory, Nora, Gorrono-Etxebarria, Irantzu, Uysal-Onganer, Pinar, Kawano, Yoshiaki, Waxman, Jonathan, Kypta, Robert M.

“…Glycogen synthase kinase (GSK‐3) is upregulated in many types of tumor, including prostate cancer. GSK‐3 inhibitors reduce prostate tumor cell growth; however,…”
Get full text

IS HSP70 A THERAPEUTIC TARGET FOR PARKINSON'S DISEASE? by Olano-Bringas, Jon, Villegas-Zafra, Patricia, Kurt, Begum, Ciceri, Dalila, Muga, Arturo, Bengoa-Vergniory, Nora

Get full text

Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons by Magno, Lorenza, Asgarian, Zeinab, Apanaviciute, Migle, Milner, Yasmin, Bengoa-Vergniory, Nora, Rubin, Anna Noren, Kessaris, Nicoletta

“…The septum is a key structure at the core of the forebrain that integrates inputs and relays information to other brain areas to support cognition and…”
Get full text

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons by Beccano-Kelly, Dayne A., Cherubini, Marta, Mousba, Yassine, Cramb, Kaitlyn M.L., Giussani, Stefania, Caiazza, Maria Claudia, Rai, Pavandeep, Vingill, Siv, Bengoa-Vergniory, Nora, Ng, Bryan, Corda, Gabriele, Banerjee, Abhirup, Vowles, Jane, Cowley, Sally, Wade-Martins, Richard

“…Parkinson’s disease (PD) is characterized by a progressive deterioration of motor and cognitive functions. Although death of dopamine neurons is the hallmark…”
Get full text

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation by Do, Quyen B., Noor, Humaira, Marquez-Gomez, Ricardo, Cramb, Kaitlyn M. L., Ng, Bryan, Abbey, Ajantha, Ibarra-Aizpurua, Naroa, Caiazza, Maria Claudia, Sharifi, Parnaz, Lang, Charmaine, Beccano-Kelly, Dayne, Baleriola, Jimena, Bengoa-Vergniory, Nora, Wade-Martins, Richard

“…Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson’s disease (PD) given the architecture of the basal…”
Get full text

Canonical and noncanonical Wnt signaling in neural stem/progenitor cells by Bengoa-Vergniory, Nora, Kypta, Robert M.

“…The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the development of a large part of the mouse brain over 25 years ago. We have…”
Get full text