Chemical characterization, cytotoxicity, antimicrobial and antioxidant potential of Justicia pectoralis Jacq and Croton jacobinensis Baill extracts

Chemical characterization, cytotoxicity, antimicrobial and antioxidant potential of Justicia pectoralis Jacq and Croton jacobinensis Baill extracts

In this research, aqueous and ethanolic extracts from Justicia pectoralis Jacq and Croton Jacobinensis Baill were characterized. The UPLC-QTOF-MSE analysis was performed on the extracts identified, predominantly, flavonoids, tannins and acids. The extracts did not indicate toxicity in human epitheli...

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Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences Vol. 59
Main Authors: Oliveira, Leilanne Márcia Nogueira de, Bastos, Maria do Socorro Rocha, Lima, Ana Cristina Silva de, Figueiredo, Evânia Altina Teixera de, Dias, Flayanna Gouveia Braga, Silva, Larissa Morais Ribeiro da, Benevides, Selene Dahia, Ribeiro, Paulo Riceli Vasconcelos, Sabino, Luiz Bruno de Sousa, Figueiredo, Raimundo Wilane de
Format: Journal Article
Language:English
Published: Sao Paulo Universidade de Sao Paulo Faculdade de Ciencias 01-01-2023
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Subjects:
Acids
Antimicrobial agents
Antioxidants
Chromatography
Cytotoxicity
Food preservation
Homogenization
Malaria
Microorganisms
Oils & fats
PHARMACOLOGY & PHARMACY
Polyphenols
Brazil
United States > US
Natural extracts
Identification
Bioactive compounds
Therapeutics
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Summary:In this research, aqueous and ethanolic extracts from Justicia pectoralis Jacq and Croton Jacobinensis Baill were characterized. The UPLC-QTOF-MSE analysis was performed on the extracts identified, predominantly, flavonoids, tannins and acids. The extracts did not indicate toxicity in human epithelial cells. C. jacobinensis presented a concentration of phenolics 60.5% higher than J. pectoralis in all scenarios evaluated and, for both samples, the hydroalcoholic extract at 70% exhibited the best efficiency in the extraction (14501.3 and 32521.5 mg GAE 100 g-1 for J. pectoralis and C. jacobinensis, respectively). The antioxidant activity presented a positive correlation with the concentration of phenolics, being 1.186,1 and 1.507,9 μM of Trolox for J. pectoralis and C. jacobinensis at 70% of ethanol; however, it was not verified statistical difference between the ethanolic solutions (p < 0.05). The antimicrobial activity of J. pectoralis extracts was highlighted once was the most effective against gram-positive bacteria. The results suggest that both J. pectoralis and C. jacobinensis extracts present the potential to be applied as natural additives due to their antioxidant and antimicrobial activity and safety. Thus, it is suggesting the development of studies that could investigate the interaction of these plant extracts with food matrices is required.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902023e21224