Search Results - "Benet, L."

Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy? by Budha, N R, Frymoyer, A, Smelick, G S, Jin, J Y, Yago, M R, Dresser, M J, Holden, S N, Benet, L Z, Ware, J A

“…A majority of the novel orally administered, molecularly targeted anticancer therapies are weak bases that exhibit pH‐dependent solubility, and suppression of…”
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An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation by Bowman, C.M., Benet, L.Z.

“…As explained by the free drug theory, the unbound fraction of drug has long been thought to drive the efficacy of a molecule. Thus, the fraction unbound term,…”
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Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance? by Benet, L.Z., Sodhi, J.K.

“…Here we present, utilizing universally accepted relationships for hepatic clearance at steady state, that for all models of hepatic elimination the ratio of…”
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Effect of OATP1B Transporter Inhibition on the Pharmacokinetics of Atorvastatin in Healthy Volunteers by Lau, Y Y, Huang, Y, Frassetto, L, Benet, L Z

“…The inhibition of hepatic uptake transporters, such as OATP1B1, on the pharmacokinetics of atorvastatin is unknown. Here, we investigate the effect of a model…”
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The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio by Benet, LZ, Liu, S, Wolfe, AR

“…For almost a half‐century clearance concepts have been utilized in pharmacokinetics to understand the relationship between the dose administered and the time…”
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Transiently antigen-primed B cells return to naive-like state in absence of T-cell help by Turner, Jackson S., Marthi, Matangi, Benet, Zachary L., Grigorova, Irina

“…The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells…”
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Elucidating Rifampin's Inducing and Inhibiting Effects on Glyburide Pharmacokinetics and Blood Glucose in Healthy Volunteers: Unmasking the Differential Effects of Enzyme Induction and Transporter Inhibition for a Drug and Its Primary Metabolite by Zheng, HX, Huang, Y, Frassetto, LA, Benet, LZ

“…The effects of single doses of intravenous (IV) ciprofloxacin and rifampin and of multiple doses of rifampin on glyburide exposure and blood glucose levels…”
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Antigen Acquisition Enables Newly Arriving B Cells To Enter Ongoing Immunization-Induced Germinal Centers by Turner, Jackson S, Benet, Zachary L, Grigorova, Irina L

“…Modern vaccines must be designed to generate long-lasting, high-affinity, and broadly neutralizing Ab responses against pathogens. The diversity of B cell…”
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Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial by Burmeister Getz, E, Carroll, KJ, Jones, B, Benet, LZ

“…Current pharmacokinetic (PK) bioequivalence guidelines do not account for batch‐to‐batch variability in study design or analysis. Here we evaluate the…”
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Between‐Batch Pharmacokinetic Variability Inflates Type I Error Rate in Conventional Bioequivalence Trials: A Randomized Advair Diskus Clinical Trial by Burmeister Getz, E, Carroll, KJ, Mielke, J, Benet, LZ, Jones, B

“…We previously demonstrated pharmacokinetic differences among manufacturing batches of a US Food and Drug Administration (FDA)‐approved dry powder inhalation…”
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Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells by Ke, Fang, Benet, Zachary L, Maz, Mitra P, Liu, Jianhua, Dent, Alexander L, Kahlenberg, Joanne Michelle, Grigorova, Irina L

“…Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral…”
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Hepatic Clearance, but Not Gut Availability, of Erythromycin Is Altered in Patients With End-Stage Renal Disease by Sun, H, Frassetto, L A, Huang, Y, Benet, L Z

“…Nonrenal clearance of drugs can be significantly lower in patients with end‐stage renal disease (ESRD) than in those with normal renal function. Using…”
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Unmasking the dynamic interplay between efflux transporters and metabolic enzymes by Benet, L.Z, Cummins, C.L, Wu, C.Y

“…Drug efflux by intestinal P-glycoprotein (P-gp) is known to decrease the bioavailability of many CYP3A4 substrates. We have demonstrated that the interplay…”
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Transiently antigen primed B cells can generate multiple subsets of memory cells by Turner, Jackson S, Benet, Zachary L, Grigorova, Irina

“…Memory B cells are long-lived cells that generate a more vigorous response upon recognition of antigen (Ag) and T cell help than naïve B cells and ensure…”
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The FDA Should Eliminate the Ambiguities in the Current BCS Biowaiver Guidance and Make Public the Drugs for Which BCS Biowaivers Have Been Granted by Benet, L Z, Larregieu, C A

“…Although US Food and Drug Administration (FDA)‐approved Biopharmaceutics Classification System (BCS) class 1 drugs are designated as high‐permeability drugs,…”
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Immunosuppressant Pharmacokinetics and Dosing Modifications in HIV‐1 Infected Liver and Kidney Transplant Recipients by Frassetto, L. A., Browne, M., Cheng, A., Wolfe, A. R., Roland, M. E., Stock, P. G., Carlson, L., Benet, L. Z.

“…Solid organ transplantation in human immunodeficiency virus (HIV)‐infected individuals requiring concomitant use of immunosuppressants (IS) (e.g. cyclosporine…”
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Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data by Benet, L Z, Cummins, C L, Wu, C Y

“…As discussed in earlier articles, predictions of in vivo drug-drug interactions from in vitro studies is a subject of high interest with obvious therapeutic as…”
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A Step Closer to Personalized Chemotherapy: Consideration of the Influence of Genetic Variation in Hepatic Uptake Transporters on the Metabolism of CYP3A Substrates by Benet, L Z

“…Understanding the metabolic, transporter, and genetic influences on the disposition of drugs used in chemotherapy is critical to individualization of drug…”
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HIV‐Infected Liver and Kidney Transplant Recipients: 1‐ and 3‐Year Outcomes by Roland, M. E., Barin, B., Carlson, L., Frassetto, L. A., Terrault, N. A., Hirose, R., Freise, C. E., Benet, L. Z., Ascher, N. L., Roberts, J. P., Murphy, B., Keller, M. J., Olthoff, K. M., Blumberg, E. A., Brayman, K. L., Bartlett, S. T., Davis, C. E., McCune, J. M., Bredt, B. M., Stablein, D. M., Stock, P. G.

“…Improvements in human immunodeficiency virus (HIV)‐associated mortality make it difficult to deny transplantation based upon futility. Outcomes in the current…”
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CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes by Benet, Zachary L, Marthi, Matangi, Ke, Fang, Wu, Rita, Turner, Jackson S, Gabayre, Jahan B, Ivanitskiy, Michael I, Sethi, Sahil S, Grigorova, Irina L

“…Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of…”
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