Search Results - "Benesch, Justin LP"

Rapid, DNA-induced interface swapping by DNA gyrase by Germe, Thomas R M, Bush, Natassja G, Baskerville, Victoria M, Saman, Dominik, Benesch, Justin L P, Maxwell, Anthony

“…DNA gyrase, a ubiquitous bacterial enzyme, is a type IIA topoisomerase formed by heterotetramerisation of 2 GyrA subunits and 2 GyrB subunits, to form the…”
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Mass spectrometry: come of age for structural and dynamical biology by Benesch, Justin LP, Ruotolo, Brandon T

“…► Mass spectrometry is a sensitive, high-resolution means for determining the oligomeric distribution of proteins. ► The different oligomers and conformers…”
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A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins by Reid Alderson, T, Adriaenssens, Elias, Asselbergh, Bob, Pritišanac, Iva, Van Lent, Jonas, Gastall, Heidi Y, Wälti, Marielle A, Louis, John M, Timmerman, Vincent, Baldwin, Andrew J, LP Benesch, Justin

“…HSP27 is a human molecular chaperone that forms large, dynamic oligomers and functions in many aspects of cellular homeostasis. Mutations in HSP27 cause…”
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A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis by Marcoux, Julien, Mangione, P Patrizia, Porcari, Riccardo, Degiacomi, Matteo T, Verona, Guglielmo, Taylor, Graham W, Giorgetti, Sofia, Raimondi, Sara, Sanglier‐Cianférani, Sarah, Benesch, Justin LP, Cecconi, Ciro, Naqvi, Mohsin M, Gillmore, Julian D, Hawkins, Philip N, Stoppini, Monica, Robinson, Carol V, Pepys, Mark B, Bellotti, Vittorio

“…The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits…”
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Mass spectrometry of macromolecular assemblies: preservation and dissociation by Benesch, Justin LP, Robinson, Carol V

“…Mass spectrometry not only plays a crucial role in the identification of proteins involved in the intricate interaction networks of the cell, but also is…”
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Mass spectrometry beyond the native state by Chandler, Shane A, Benesch, Justin LP

“…•Native mass spectrometry allows the interrogation of protein conformational space.•Manipulation of charge populates different minima in the protein folding…”
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Weighing-up protein dynamics: the combination of native mass spectrometry and molecular dynamics simulations by Marklund, Erik G, Benesch, Justin LP

“…•Native mass spectrometry provides coarse structural and dynamics information.•Molecular dynamics simulations operate at the atomic level.•Integrating these…”
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Recommendations for reporting ion mobility Mass Spectrometry measurements by Gabelica, Valérie, Shvartsburg, Alexandre A., Afonso, Carlos, Barran, Perdita, Benesch, Justin L.P., Bleiholder, Christian, Bowers, Michael T., Bilbao, Aivett, Bush, Matthew F., Campbell, J. Larry, Campuzano, Iain D.G., Causon, Tim, Clowers, Brian H., Creaser, Colin S., De Pauw, Edwin, Far, Johann, Fernandez‐Lima, Francisco, Fjeldsted, John C., Giles, Kevin, Groessl, Michael, Hogan, Christopher J., Hann, Stephan, Kim, Hugh I., Kurulugama, Ruwan T., May, Jody C., McLean, John A., Pagel, Kevin, Richardson, Keith, Ridgeway, Mark E., Rosu, Frédéric, Sobott, Frank, Thalassinos, Konstantinos, Valentine, Stephen J., Wyttenbach, Thomas

“…Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements…”
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Small heat-shock proteins and their role in mechanical stress by Collier, Miranda P., Benesch, Justin L.P.

“…The ability of cells to respond to stress is central to health. Stress can damage folded proteins, which are vulnerable to even minor changes in cellular…”
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The Role of the Detergent Micelle in Preserving the Structure of Membrane Proteins in the Gas Phase by Reading, Eamonn, Liko, Idlir, Allison, Timothy M., Benesch, Justin L. P., Laganowsky, Arthur, Robinson, Carol V.

“…Despite the growing importance of the mass spectrometry of membrane proteins, it is not known how their transfer from solution into vacuum affects their…”
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The adaptability of the ion-binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF by Lithgo, Ryan M, Hanževački, Marko, Harris, Gemma, Kamps, Jos J A G, Holden, Ellie, Gianga, Tiberiu-Marius, Benesch, Justin L P, Jäger, Christof M, Croft, Anna K, Hussain, Rohannah, Hobman, Jon L, Orville, Allen M, Quigley, Andrew, Carr, Stephen B, Scott, David J

“…The periplasmic chaperone SilF has been identified as part of an Ag(I) detoxification system in Gram-negative bacteria. Sil proteins also bind Cu(I) but with…”
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Low Charge and Reduced Mobility of Membrane Protein Complexes Has Implications for Calibration of Collision Cross Section Measurements by Allison, Timothy M, Landreh, Michael, Benesch, Justin L. P, Robinson, Carol V

“…Ion mobility mass spectrometry of integral membrane proteins provides valuable insights into their architecture and stability. Here we show that, due to their…”
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GlycoMob: an ion mobility-mass spectrometry collision cross section database for glycomics by Struwe, Weston B., Pagel, Kevin, Benesch, Justin L. P., Harvey, David J., Campbell, Matthew P.

“…Ion mobility mass spectrometry (IM-MS) is a promising analytical technique for glycomics that separates glycan ions based on their collision cross section…”
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Characterisation of ShigellaSpa33 and ThermotogaFliM/N reveals a new model for C-ring assembly in T3SS by McDowell, Melanie A, Marcoux, Julien, McVicker, Gareth, Johnson, Steven, Fong, Yu Hang, Stevens, Rebecca, Bowman, Lesley A H, Degiacomi, Matteo T, Yan, Jun, Wise, Adam, Friede, Miriam E, Benesch, Justin L P, Deane, Janet E, Tang, Christoph M, Robinson, Carol V, Lea, Susan M

“…Summary Flagellar type III secretion systems (T3SS) contain an essential cytoplasmic-ring (C-ring) largely composed of two proteins FliM and FliN, whereas an…”
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Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation by McAlary, Luke, Harrison, Julian A, Aquilina, J. Andrew, Fitzgerald, Steven P, Kelso, Celine, Benesch, Justin L.P, Yerbury, Justin J

“…Native mass spectrometry (MS) is a powerful means for studying macromolecular protein assemblies, including accessing activated states. However, much remains…”
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The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases by Markolovic, Suzana, Zhuang, Qinqin, Wilkins, Sarah E., Eaton, Charlotte D., Abboud, Martine I., Katz, Maximiliano J., McNeil, Helen E., Leśniak, Robert K., Hall, Charlotte, Struwe, Weston B., Konietzny, Rebecca, Davis, Simon, Yang, Ming, Ge, Wei, Benesch, Justin L. P., Kessler, Benedikt M., Ratcliffe, Peter J., Cockman, Matthew E., Fischer, Roman, Wappner, Pablo, Chowdhury, Rasheduzzaman, Coleman, Mathew L., Schofield, Christopher J.

“…Biochemical, structural and cellular studies reveal Jumonji-C (JmjC) domain-containing 7 (JMJD7) to be a 2-oxoglutarate (2OG)-dependent oxygenase that…”
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Infrared Laser Activation of Soluble and Membrane Protein Assemblies in the Gas Phase by Mikhailov, Victor A, Liko, Idlir, Mize, Todd H, Bush, Matthew F, Benesch, Justin L. P, Robinson, Carol V

“…Collision-induced dissociation (CID) is the dominant method for probing intact macromolecular complexes in the gas phase by means of mass spectrometry (MS)…”
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Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1 by Brem, Jürgen, Struwe, Weston B., Rydzik, Anna M., Tarhonskaya, Hanna, Pfeffer, Inga, Flashman, Emily, van Berkel, Sander S., Spencer, James, Claridge, Timothy D. W., McDonough, Michael A., Benesch, Justin L. P., Schofield, Christopher J.

“…Metallo-β-lactamases (MBLs) catalyse the hydrolysis of almost all β-lactam antibiotics. We report biophysical and kinetic studies on the São Paulo MBL (SPM-1),…”
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Defining the Structural Basis of Human Plasminogen Binding by Streptococcal Surface Enolase by Cork, Amanda J., Jergic, Slobodan, Hammerschmidt, Sven, Kobe, Bostjan, Pancholi, Vijay, Benesch, Justin L.P., Robinson, Carol V., Dixon, Nicholas E., Aquilina, J. Andrew, Walker, Mark J.

“…The flesh-eating bacterium group A Streptococcus (GAS) binds and activates human plasminogen, promoting invasive disease. Streptococcal surface enolase (SEN),…”
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Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase by Rydzik, Anna M., Brem, Jürgen, Struwe, Weston B., Kochan, Grazyna T., Benesch, Justin L.P., Schofield, Christopher J.

“…[Display omitted] γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine…”
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