Search Results - "Beneke, Angelika"

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen by Siegert, Isabel, Schödel, Johannes, Nairz, Manfred, Schatz, Valentin, Dettmer, Katja, Dick, Christopher, Kalucka, Joanna, Franke, Kristin, Ehrenschwender, Martin, Schley, Gunnar, Beneke, Angelika, Sutter, Jörg, Moll, Matthias, Hellerbrand, Claus, Wielockx, Ben, Katschinski, Dörthe M., Lang, Roland, Galy, Bruno, Hentze, Matthias W., Koivunen, Peppi, Oefner, Peter J., Bogdan, Christian, Weiss, Günter, Willam, Carsten, Jantsch, Jonathan

“…Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1α and nuclear factor (NF)-κB, which play a…”
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Prolyl‐4‐hydroxylase domain 3 (PHD3) is a critical terminator for cell survival of macrophages under stress conditions by Swain, Lija, Wottawa, Marieke, Hillemann, Annette, Beneke, Angelika, Odagiri, Haruki, Terada, Kazutoyo, Endo, Motoyoshi, Oike, Yuichi, Farhat, Katja, Katschinski, Dörthe M.

“…PHD3 influences apoptotic cell survival decisions in macrophages by altered production of Angiopoietin‐like protein 2. On a molecular level, cells sense…”
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Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis by Schley, Gunnar, Klanke, Bernd, Kalucka, Joanna, Schatz, Valentin, Daniel, Christoph, Mayer, Marleen, Goppelt-Struebe, Margarete, Herrmann, Martin, Thorsteinsdottir, Margret, Palsson, Runolfur, Beneke, Angelika, Katschinski, Dörthe M, Burzlaff, Nicolai, Eckardt, Kai-Uwe, Weidemann, Alexander, Jantsch, Jonathan, Willam, Carsten

“…Prolyl hydroxylase domain enzyme inhibitors (PHDIs) stabilize hypoxia-inducible factors (HIFs), and are protective in models of acute ischemic and inflammatory…”
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Loss of PHD3 in myeloid cells dampens the inflammatory response and fibrosis after hind-limb ischemia by Beneke, Angelika, Guentsch, Annemarie, Hillemann, Annette, Zieseniss, Anke, Swain, Lija, Katschinski, Dörthe M

“…Macrophages are essential for the inflammatory response after an ischemic insult and thereby influence tissue recovery. For the oxygen sensing…”
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PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages by Guentsch, Annemarie, Beneke, Angelika, Swain, Lija, Farhat, Katja, Nagarajan, Shunmugam, Wielockx, Ben, Raithatha, Kaamini, Dudek, Jan, Rehling, Peter, Zieseniss, Anke, Jatho, Aline, Chong, Mei, Santos, Celio X. C., Shah, Ajay M., Katschinski, Dörthe M.

“…The prolyl-4-hydroxylase domain (PHD) enzymes are regarded as the molecular oxygen sensors. There is an interplay between oxygen availability and cellular…”
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