Search Results - "Benedikt Brors"

Accurate and efficient detection of gene fusions from RNA sequencing data by Uhrig, Sebastian, Ellermann, Julia, Walther, Tatjana, Burkhardt, Pauline, Fröhlich, Martina, Hutter, Barbara, Toprak, Umut H, Neumann, Olaf, Stenzinger, Albrecht, Scholl, Claudia, Fröhling, Stefan, Brors, Benedikt

“…The identification of gene fusions from RNA sequencing data is a routine task in cancer research and precision oncology. However, despite the availability of…”
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Assessment of modelling strategies for drug response prediction in cell lines and xenografts by Kurilov, Roman, Haibe-Kains, Benjamin, Brors, Benedikt

“…Data from several large high-throughput drug response screens have become available to the scientific community recently. Although many efforts have been made…”
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Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF by Delacher, Michael, Imbusch, Charles D., Hotz-Wagenblatt, Agnes, Mallm, Jan-Philipp, Bauer, Katharina, Simon, Malte, Riegel, Dania, Rendeiro, André F., Bittner, Sebastian, Sanderink, Lieke, Pant, Asmita, Schmidleithner, Lisa, Braband, Kathrin L., Echtenachter, Bernd, Fischer, Alexander, Giunchiglia, Valentina, Hoffmann, Petra, Edinger, Matthias, Bock, Christoph, Rehli, Michael, Brors, Benedikt, Schmidl, Christian, Feuerer, Markus

“…Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for…”
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Distributed Ledger Technology in genomics: a call for Europe by Thiebes, Scott, Schlesner, Matthias, Brors, Benedikt, Sunyaev, Ali

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Immune cell type signature discovery and random forest classification for analysis of single cell gene expression datasets by Aybey, Bogac, Zhao, Sheng, Brors, Benedikt, Staub, Eike

“…BackgroundRobust immune cell gene expression signatures are central to the analysis of single cell studies. Nearly all known sets of immune cell signatures…”
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DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia by Oakes, Christopher C, Seifert, Marc, Assenov, Yassen, Gu, Lei, Przekopowitz, Martina, Ruppert, Amy S, Wang, Qi, Imbusch, Charles D, Serva, Andrius, Koser, Sandra D, Brocks, David, Lipka, Daniel B, Bogatyrova, Olga, Weichenhan, Dieter, Brors, Benedikt, Rassenti, Laura, Kipps, Thomas J, Mertens, Daniel, Zapatka, Marc, Lichter, Peter, Döhner, Hartmut, Küppers, Ralf, Zenz, Thorsten, Stilgenbauer, Stephan, Byrd, John C, Plass, Christoph

“…Christoph Plass, Christopher Oakes and colleagues study genome-wide DNA methylation dynamics during B cell maturation and the pathogenic role of transcription…”
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Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing by Hovestadt, Volker, Jones, David T. W., Picelli, Simone, Wang, Wei, Kool, Marcel, Northcott, Paul A., Sultan, Marc, Stachurski, Katharina, Ryzhova, Marina, Warnatz, Hans-Jörg, Ralser, Meryem, Brun, Sonja, Bunt, Jens, Jäger, Natalie, Kleinheinz, Kortine, Erkek, Serap, Weber, Ursula D., Bartholomae, Cynthia C., von Kalle, Christof, Lawerenz, Chris, Eils, Jürgen, Koster, Jan, Versteeg, Rogier, Milde, Till, Witt, Olaf, Schmidt, Sabine, Wolf, Stephan, Pietsch, Torsten, Rutkowski, Stefan, Scheurlen, Wolfram, Taylor, Michael D., Brors, Benedikt, Felsberg, Jörg, Reifenberger, Guido, Borkhardt, Arndt, Lehrach, Hans, Wechsler-Reya, Robert J., Eils, Roland, Yaspo, Marie-Laure, Landgraf, Pablo, Korshunov, Andrey, Zapatka, Marc, Radlwimmer, Bernhard, Pfister, Stefan M., Lichter, Peter

“…Medulloblastoma is a malignant childhood brain tumour presenting major clinical challenges; here, a comprehensive genome-wide DNA methylation data set from…”
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Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer by Ishaque, Naveed, Abba, Mohammed L., Hauser, Christine, Patil, Nitin, Paramasivam, Nagarajan, Huebschmann, Daniel, Leupold, Jörg Hendrik, Balasubramanian, Gnana Prakash, Kleinheinz, Kortine, Toprak, Umut H., Hutter, Barbara, Benner, Axel, Shavinskaya, Anna, Zhou, Chan, Gu, Zuguang, Kerssemakers, Jules, Marx, Alexander, Moniuszko, Marcin, Kozlowski, Miroslaw, Reszec, Joanna, Niklinski, Jacek, Eils, Jürgen, Schlesner, Matthias, Eils, Roland, Brors, Benedikt, Allgayer, Heike

“…Incomplete understanding of the metastatic process hinders personalized therapy. Here we report the most comprehensive whole-genome study of colorectal…”
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Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation by Michel, Chloé, Miller, Corey N, Küchler, Rita, Brors, Benedikt, Anderson, Mark S, Kyewski, Bruno, Pinto, Sheena

“…The basic two-step terminal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from immature MHC class II (MHCII) to mature MHCII…”
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Transcriptomic diversity in human medullary thymic epithelial cells by Carter, Jason A., Strömich, Léonie, Peacey, Matthew, Chapin, Sarah R., Velten, Lars, Steinmetz, Lars M., Brors, Benedikt, Pinto, Sheena, Meyer, Hannah V.

“…The induction of central T cell tolerance in the thymus depends on the presentation of peripheral self-epitopes by medullary thymic epithelial cells (mTECs)…”
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TelomereHunter - in silico estimation of telomere content and composition from cancer genomes by Feuerbach, Lars, Sieverling, Lina, Deeg, Katharina I, Ginsbach, Philip, Hutter, Barbara, Buchhalter, Ivo, Northcott, Paul A, Mughal, Sadaf S, Chudasama, Priya, Glimm, Hanno, Scholl, Claudia, Lichter, Peter, Fröhling, Stefan, Pfister, Stefan M, Jones, David T W, Rippe, Karsten, Brors, Benedikt

“…Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular…”
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Cross-platform analysis of cancer microarray data improves gene expression based classification of phenotypes by Warnat, Patrick, Eils, Roland, Brors, Benedikt

“…The extensive use of DNA microarray technology in the characterization of the cell transcriptome is leading to an ever increasing amount of microarray data…”
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Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer by Brocks, David, Assenov, Yassen, Minner, Sarah, Bogatyrova, Olga, Simon, Ronald, Koop, Christina, Oakes, Christopher, Zucknick, Manuela, Lipka, Daniel Bernhard, Weischenfeldt, Joachim, Feuerbach, Lars, Cowper-Sal·lari, Richard, Lupien, Mathieu, Brors, Benedikt, Korbel, Jan, Schlomm, Thorsten, Tanay, Amos, Sauter, Guido, Gerhäuser, Clarissa, Plass, Christoph

“…Despite much evidence on epigenetic abnormalities in cancer, it is currently unclear to what extent epigenetic alterations can be associated with tumors’…”
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Selective elimination of immunosuppressive T cells in patients with multiple myeloma by Awwad, Mohamed H. S., Mahmoud, Abdelrahman, Bruns, Heiko, Echchannaoui, Hakim, Kriegsmann, Katharina, Lutz, Raphael, Raab, Marc S., Bertsch, Uta, Munder, Markus, Jauch, Anna, Weisel, Katja, Maier, Bettina, Weinhold, Niels, Salwender, Hans Jürgen, Eckstein, Volker, Hänel, Mathias, Fenk, Roland, Dürig, Jan, Brors, Benedikt, Benner, Axel, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Hundemer, Michael

“…Elimination of suppressive T cells may enable and enhance cancer immunotherapy. Here, we demonstrate that the cell membrane protein SLAMF7 was highly expressed…”
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Defective homologous recombination DNA repair as therapeutic target in advanced chordoma by Gröschel, Stefan, Hübschmann, Daniel, Raimondi, Francesco, Horak, Peter, Warsow, Gregor, Fröhlich, Martina, Klink, Barbara, Gieldon, Laura, Hutter, Barbara, Kleinheinz, Kortine, Bonekamp, David, Marschal, Oliver, Chudasama, Priya, Mika, Jagoda, Groth, Marie, Uhrig, Sebastian, Krämer, Stephen, Heining, Christoph, Heilig, Christoph E., Richter, Daniela, Reisinger, Eva, Pfütze, Katrin, Eils, Roland, Wolf, Stephan, von Kalle, Christof, Brandts, Christian, Scholl, Claudia, Weichert, Wilko, Richter, Stephan, Bauer, Sebastian, Penzel, Roland, Schröck, Evelin, Stenzinger, Albrecht, Schlenk, Richard F., Brors, Benedikt, Russell, Robert B., Glimm, Hanno, Schlesner, Matthias, Fröhling, Stefan

“…Chordomas are rare bone tumors with few therapeutic options. Here we show, using whole-exome and genome sequencing within a precision oncology program, that…”
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Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity by Möhrmann, Lino, Werner, Maximilian, Oleś, Małgorzata, Mock, Andreas, Uhrig, Sebastian, Jahn, Arne, Kreutzfeldt, Simon, Fröhlich, Martina, Hutter, Barbara, Paramasivam, Nagarajan, Richter, Daniela, Beck, Katja, Winter, Ulrike, Pfütze, Katrin, Heilig, Christoph E., Teleanu, Veronica, Lipka, Daniel B., Zapatka, Marc, Hanf, Dorothea, List, Catrin, Allgäuer, Michael, Penzel, Roland, Rüter, Gina, Jelas, Ivan, Hamacher, Rainer, Falkenhorst, Johanna, Wagner, Sebastian, Brandts, Christian H., Boerries, Melanie, Illert, Anna L., Metzeler, Klaus H., Westphalen, C. Benedikt, Desuki, Alexander, Kindler, Thomas, Folprecht, Gunnar, Weichert, Wilko, Brors, Benedikt, Stenzinger, Albrecht, Schröck, Evelin, Hübschmann, Daniel, Horak, Peter, Heining, Christoph, Fröhling, Stefan, Glimm, Hanno

“…The benefit of molecularly-informed therapies in cancer of unknown primary (CUP) is unclear. Here, we use comprehensive molecular characterization by whole…”
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Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies by Denisova, Evgeniya, Westphal, Dana, Surowy, Harald M., Meier, Friedegund, Hutter, Barbara, Reifenberger, Julia, Rütten, Arno, Schulz, Alexander, Sergon, Mildred, Ziemer, Mirjana, Brors, Benedikt, Betz, Regina C., Redler, Silke

“…Malignant sweat gland tumours are rare, with the most common form being Eccrine porocarcinoma (EP). To investigate the mutational landscape of EP, we performed…”
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Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin by Rodríguez-Paredes, Manuel, Bormann, Felix, Raddatz, Günter, Gutekunst, Julian, Lucena-Porcel, Carlota, Köhler, Florian, Wurzer, Elisabeth, Schmidt, Katrin, Gallinat, Stefan, Wenck, Horst, Röwert-Huber, Joachim, Denisova, Evgeniya, Feuerbach, Lars, Park, Jeongbin, Brors, Benedikt, Herpel, Esther, Nindl, Ingo, Hofmann, Thomas G., Winnefeld, Marc, Lyko, Frank

“…Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic…”
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IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer by Zorea, Jonatan, Prasad, Manu, Cohen, Limor, Li, Nan, Schefzik, Roman, Ghosh, Susmita, Rotblat, Barak, Brors, Benedikt, Elkabets, Moshe

“…Genomic alterations (GA) in PIK3CA leads to the hyper-activation of the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway in more than 20% of…”
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Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity by Pinto, Sheena, Michel, Chloé, Schmidt-Glenewinkel, Hannah, Harder, Nathalie, Rohr, Karl, Wild, Stefan, Brors, Benedikt, Kyewski, Bruno

“…Promiscuous expression of numerous tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is essential to safeguard…”
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