Search Results - "Benedict, Chris"

Cytomegalovirus: Shape-Shifting the Immune System by Picarda, Gaëlle, Benedict, Chris A

“…Systems-based based approaches have begun to shed light on extrinsic factors that contribute to immune system variation. Among these, CMV (HHV-5, a…”
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Clinical targeting of the TNF and TNFR superfamilies by Croft, Michael, Benedict, Chris A., Ware, Carl F.

“…Key Points Inhibitors of tumour necrosis factor (TNF) are among the most successful protein-based drugs for reducing inflammation associated with several…”
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A noncanonical function of cGAMP in inflammasome priming and activation by Swanson, Karen V, Junkins, Robert D, Kurkjian, Cathryn J, Holley-Guthrie, Elizabeth, Pendse, Avani A, El Morabiti, Rachid, Petrucelli, Alex, Barber, Glen N, Benedict, Chris A, Ting, Jenny P-Y

“…Recognition of pathogen-associated molecular patterns and danger-associated molecular patterns by host cells is an important step in innate immune activation…”
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Late-rising CD4 T cells resolve mouse cytomegalovirus persistent replication in the salivary gland by Brunel, Simon, Picarda, Gaelle, Gupta, Ankan, Ghosh, Raima, McDonald, Bryan, El Morabiti, Rachid, Jiang, Wenjin, Greenbaum, Jason A, Adler, Barbara, Seumois, Gregory, Croft, Michael, Vijayanand, Pandurangan, Benedict, Chris A

“…Conventional antiviral memory CD4 T cells typically arise during the first two weeks of acute infection. Unlike most viruses, cytomegalovirus (CMV) exhibits an…”
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Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B 100 -Reactive CD4 + T-Regulatory Cells by Wolf, Dennis, Gerhardt, Teresa, Winkels, Holger, Michel, Nathaly Anto, Pramod, Akula Bala, Ghosheh, Yanal, Brunel, Simon, Buscher, Konrad, Miller, Jacqueline, McArdle, Sara, Baas, Livia, Kobiyama, Kouji, Vassallo, Melanie, Ehinger, Erik, Dileepan, Thamotharampillai, Ali, Amal, Schell, Maximilian, Mikulski, Zbigniew, Sidler, Daniel, Kimura, Takayuki, Sheng, Xia, Horstmann, Hauke, Hansen, Sophie, Mitre, Lucia Sol, Stachon, Peter, Hilgendorf, Ingo, Gaddis, Dalia E, Hedrick, Catherine, Benedict, Chris A, Peters, Bjoern, Zirlik, Andreas, Sette, Alessandro, Ley, Klaus

“…Throughout the inflammatory response that accompanies atherosclerosis, autoreactive CD4 T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein…”
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Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection by Verma, Shilpi, Weiskopf, Daniela, Gupta, Ankan, McDonald, Bryan, Peters, Bjoern, Sette, Alessandro, Benedict, Chris A

“…CD4 T cells provide protection against cytomegalovirus (CMV) and other persistent viruses, and the ability to quantify and characterize epitope-specific…”
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IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence by Wehrens, Ellen J, Wong, Kurt A, Gupta, Ankan, Khan, Ayesha, Benedict, Chris A, Zuniga, Elina I

“…The role of IL-27 in antiviral immunity is still incompletely understood, especially in the context of chronic viruses that induce a unique environment in…”
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cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection by Lio, Chan-Wang J, McDonald, Bryan, Takahashi, Mariko, Dhanwani, Rekha, Sharma, Nikita, Huang, Jenny, Pham, Elise, Benedict, Chris A, Sharma, Sonia

“…Several innate sensing pathways contribute to the control of early cytomegalovirus (CMV) infection, leading to a multiphasic type I interferon (IFN-I) response…”
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Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling by Bitra, Aruna, Doukov, Tzanko, Wang, Jing, Picarda, Gaelle, Benedict, Chris A., Croft, Michael, Zajonc, Dirk M.

“…4-1BB (CD137) is a TNF receptor superfamily (TNFRSF) member that is thought to undergo receptor trimerization upon binding to its trimeric TNF superfamily…”
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Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions by Nemčovičová, Ivana, Benedict, Chris A, Zajonc, Dirk M

“…The TRAIL (TNF-related apoptosis inducing ligand) death receptors (DRs) of the tumor necrosis factor receptor superfamily (TNFRSF) can promote apoptosis and…”
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Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8 + T cells by Delpoux, Arnaud, Michelini, Rodrigo Hess, Verma, Shilpi, Lai, Chen-Yen, Omilusik, Kyla D, Utzschneider, Daniel T, Redwood, Alec J, Goldrath, Ananda W, Benedict, Chris A, Hedrick, Stephen M

“…Upon infection with an intracellular pathogen, cytotoxic CD8 T cells develop diverse differentiation states characterized by function, localization, longevity,…”
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Distinct requirements for activation of NKT and NK cells during viral infection by Tyznik, Aaron J, Verma, Shilpi, Wang, Qiao, Kronenberg, Mitchell, Benedict, Chris A

“…NK cells are key regulators of innate defense against mouse CMV (MCMV). Like NK cells, NKT cells also produce high levels of IFN-γ rapidly after MCMV…”
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DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB by Rebsamen, Manuele, Heinz, Leonhard X, Meylan, Etienne, Michallet, Marie-Cécile, Schroder, Kate, Hofmann, Kay, Vazquez, Jessica, Benedict, Chris A, Tschopp, Jürg

“…Detection of viral nucleic acids is central to antiviral immunity. Recently, DAI/ZBP1 (DNA‐dependent activator of IRFs/Z‐DNA binding protein 1) was identified…”
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Structure of human cytomegalovirus UL144, an HVEM orthologue, bound to the B and T cell lymphocyte attenuator by Bitra, Aruna, Nemčovičová, Ivana, Picarda, Gaelle, Doukov, Tzanko, Wang, Jing, Benedict, Chris A., Zajonc, Dirk M.

“…Human cytomegalovirus (HCMV) is a β-herpesvirus that has co-evolved with the host immune system to establish lifelong persistence. HCMV encodes many…”
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Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation by Kawakami, Yu, Takazawa, Ikuo, Fajt, Merritt L., Kasakura, Kazumi, Lin, Joseph, Ferrer, Julienne, Kantor, David B., Phipatanakul, Wanda, Heymann, Peter W., Benedict, Chris A., Kawakami, Yuko, Kawakami, Toshiaki

“…[Display omitted] Histamine-releasing factor (HRF) is implicated in allergic diseases. We previously showed its pathogenic role in murine models of asthma. We…”
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Profiling Human Cytomegalovirus-Specific T Cell Responses Reveals Novel Immunogenic Open Reading Frames by Dhanwani, Rekha, Dhanda, Sandeep Kumar, Pham, John, Williams, Gregory P, Sidney, John, Grifoni, Alba, Picarda, Gaelle, Lindestam Arlehamn, Cecilia S, Sette, Alessandro, Benedict, Chris A

“…Despite the prevalence and medical significance of human cytomegalovirus (HCMV) infections, a systematic analysis of the targets of T cell recognition in…”
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Cytomegalovirus Evades TRAIL-Mediated Innate Lymphoid Cell 1 Defenses by Picarda, Gaelle, Ghosh, Raima, McDonald, Bryan, Verma, Shilpi, Thiault, Nicolas, El Morabiti, Rachid, Griffith, Thomas S, Benedict, Chris A

“…Cytomegalovirus (CMV) establishes a lifelong infection facilitated, in part, by circumventing immune defenses mediated by tumor necrosis factor (TNF)-family…”
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Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense by Verma, Shilpi, Loewendorf, Andrea, Wang, Qiao, McDonald, Bryan, Redwood, Alec, Benedict, Chris A

“…TNF-related apoptosis inducing ligand (TRAIL) death receptors (DR) regulate apoptosis and inflammation, but their role in antiviral defense is poorly…”
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Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral Defenses by Smith, Wendell, Tomasec, Peter, Aicheler, Rebecca, Loewendorf, Andrea, Nemčovičová, Ivana, Wang, Eddie C.Y., Stanton, Richard J., Macauley, Matt, Norris, Paula, Willen, Laure, Ruckova, Eva, Nomoto, Akio, Schneider, Pascal, Hahn, Gabriele, Zajonc, Dirk M., Ware, Carl F., Wilkinson, Gavin W.G., Benedict, Chris A.

“…Death receptors (DRs) of the TNFR superfamily contribute to antiviral immunity by promoting apoptosis and regulating immune homeostasis during infection, and…”
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Restriction of Human Cytomegalovirus Infection by Galectin-9 by Machala, Emily A, Avdic, Selmir, Stern, Lauren, Zajonc, Dirk M, Benedict, Chris A, Blyth, Emily, Gottlieb, David J, Abendroth, Allison, McSharry, Brian P, Slobedman, Barry

“…Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. While HCMV infection is generally asymptomatic in the immunocompetent, it can have devastating…”
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