Search Results - "Benedet, L."

Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology by Ashton, Nicholas J., Pascoal, Tharick A., Karikari, Thomas K., Benedet, Andréa L., Lantero-Rodriguez, Juan, Brinkmalm, Gunnar, Snellman, Anniina, Schöll, Michael, Troakes, Claire, Hye, Abdul, Gauthier, Serge, Vanmechelen, Eugeen, Zetterberg, Henrik, Rosa-Neto, Pedro, Blennow, Kaj

“…The quantification of phosphorylated tau in biofluids, either cerebrospinal fluid (CSF) or plasma, has shown great promise in detecting Alzheimer’s disease…”
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Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility by Karikari, Thomas K., Ashton, Nicholas J., Brinkmalm, Gunnar, Brum, Wagner S., Benedet, Andréa L., Montoliu-Gaya, Laia, Lantero-Rodriguez, Juan, Pascoal, Tharick Ali, Suárez-Calvet, Marc, Rosa-Neto, Pedro, Blennow, Kaj, Zetterberg, Henrik

“…Well-authenticated biomarkers can provide critical insights into the biological basis of Alzheimer disease (AD) to enable timely and accurate diagnosis,…”
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Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative by Karikari, Thomas K., Benedet, Andréa L., Ashton, Nicholas J., Lantero Rodriguez, Juan, Snellman, Anniina, Suárez-Calvet, Marc, Saha-Chaudhuri, Paramita, Lussier, Firoza, Kvartsberg, Hlin, Rial, Alexis Moscoso, Pascoal, Tharick A., Andreasson, Ulf, Schöll, Michael, Weiner, Michael W., Rosa-Neto, Pedro, Trojanowski, John Q., Shaw, Leslie M., Blennow, Kaj, Zetterberg, Henrik

“…Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of…”
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Microglial activation and tau propagate jointly across Braak stages by Pascoal, Tharick A., Benedet, Andrea L., Ashton, Nicholas J., Kang, Min Su, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Lussier, Firoza Z., Tissot, Cécile, Karikari, Thomas K., Ottoy, Julie, Mathotaarachchi, Sulantha, Stevenson, Jenna, Massarweh, Gassan, Schöll, Michael, de Leon, Mony J., Soucy, Jean-Paul, Edison, Paul, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer’s disease (AD)…”
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Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum by Benedet, Andréa L, Milà-Alomà, Marta, Vrillon, Agathe, Ashton, Nicholas J, Pascoal, Tharick A, Lussier, Firoza, Karikari, Thomas K, Hourregue, Claire, Cognat, Emmanuel, Dumurgier, Julien, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina M, Salvadó, Gemma, Shekari, Mahnaz, Operto, Gregory, Gispert, Juan Domingo, Minguillon, Carolina, Fauria, Karine, Kollmorgen, Gwendlyn, Suridjan, Ivonne, Zimmer, Eduardo R, Zetterberg, Henrik, Molinuevo, José Luis, Paquet, Claire, Rosa-Neto, Pedro, Blennow, Kaj, Suárez-Calvet, Marc

“…Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that increases in the cerebrospinal fluid (CSF) and blood of individuals with…”
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A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis by Leuzy, Antoine, Pascoal, Tharick A., Strandberg, Olof, Insel, Philip, Smith, Ruben, Mattsson-Carlgren, Niklas, Benedet, Andréa L., Cho, Hannah, Lyoo, Chul H., La Joie, Renaud, Rabinovici, Gil D., Ossenkoppele, Rik, Rosa-Neto, Pedro, Hansson, Oskar

“…Purpose This study aims to determine whether comparable target regions of interest (ROIs) and cut-offs can be used across [ 18 F]flortaucipir, [ 18 F]RO948,…”
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The accuracy and robustness of plasma biomarker models for amyloid PET positivity by Benedet, Andréa L, Brum, Wagner S, Hansson, Oskar, Karikari, Thomas K, Zimmer, Eduardo R, Zetterberg, Henrik, Blennow, Kaj, Ashton, Nicholas J

“…Plasma biomarkers for Alzheimer's disease (AD) have broad potential as screening tools in primary care and disease-modifying trials. Detecting elevated…”
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Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease by Benedet, Andréa L, Leuzy, Antoine, Pascoal, Tharick A, Ashton, Nicholas J, Mathotaarachchi, Sulantha, Savard, Melissa, Therriault, Joseph, Kang, Min Su, Chamoun, Mira, Schöll, Michael, Zimmer, Eduardo R, Gauthier, Serge, Labbe, Aurélie, Zetterberg, Henrik, Rosa-Neto, Pedro, Blennow, Kaj

“…Neurofilament light (NfL) is a marker of neuroaxonal injury, a prominent feature of Alzheimer's disease. It remains uncertain, however, how it relates to…”
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Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer's disease by Tissot, Cécile, L Benedet, Andréa, Therriault, Joseph, Pascoal, Tharick A, Lussier, Firoza Z, Saha-Chaudhuri, Paramita, Chamoun, Mira, Savard, Melissa, Mathotaarachchi, Sulantha S, Bezgin, Gleb, Wang, Yi-Ting, Fernandez Arias, Jaime, Rodriguez, Juan Lantero, Snellman, Anniina, Ashton, Nicholas J, Karikari, Thomas K, Blennow, Kaj, Zetterberg, Henrik, De Villers-Sidani, Etienne, Huot, Philippe, Gauthier, Serge, Rosa-Neto, Pedro

“…To investigate the association of plasma pTau181, assessed with a new immunoassay, with neurodegeneration of white matter and gray matter cross-sectionally and…”
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Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease by Ashton, Nicholas J., Benedet, Andréa L., Pascoal, Tharick A., Karikari, Thomas K., Lantero-Rodriguez, Juan, Brum, Wagner S., Mathotaarachchi, Sulantha, Therriault, Joseph, Savard, Melissa, Chamoun, Mira, Stoops, Erik, Francois, Cindy, Vanmechelen, Eugeen, Gauthier, Serge, Zimmer, Eduardo R., Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro

“…Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD)…”
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Differences between blood and cerebrospinal fluid glial fibrillary Acidic protein levels: The effect of sample stability by Simrén, Joel, Weninger, Haley, Brum, Wagner S., Khalil, Shilla, Benedet, Andréa L., Blennow, Kaj, Zetterberg, Henrik, Ashton, Nicholas J.

“…Introduction Recent evidence has shown that the marker of reactive astrogliosis, glial fibrillary acidic protein (GFAP), has a stronger relationship with…”
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Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages by Pascoal, Tharick A, Benedet, Andrea L, Tudorascu, Dana L, Therriault, Joseph, Mathotaarachchi, Sulantha, Savard, Melissa, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Kang, Min Su, Stevenson, Jenna, Massarweh, Gassan, Guiot, Marie-Christine, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

“…Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is crucial to better understand the natural history of tau pathology…”
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Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease by Tissot, Cécile, Therriault, Joseph, Pascoal, Tharick A., Chamoun, Mira, Lussier, Firoza Z., Savard, Melissa, Mathotaarachchi, Sulantha S., L. Benedet, Andréa, Thomas, Emilie M., Parsons, Marlee, Nasreddine, Ziad, Rosa‐Neto, Pedro, Gauthier, Serge

“…Background Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer's disease (AD). Here we study the relationship between NPS and AD pathologies in…”
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Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease continuum by Gobom, Johan, Benedet, Andréa L, Mattsson-Carlgren, Niklas, Montoliu-Gaya, Laia, Schultz, Nina, Ashton, Nicholas J, Janelidze, Shorena, Servaes, Stijn, Sauer, Mathias, Pascoal, Tharick A, Karikari, Thomas K, Lantero-Rodriguez, Juan, Brinkmalm, Gunnar, Zetterberg, Henrik, Hansson, Oskar, Rosa-Neto, Pedro, Blennow, Kaj

“…Alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different…”
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Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease by Ng, Kok Pin, Pascoal, Tharick A, Mathotaarachchi, Sulantha, Chung, Chang-Oh, Benedet, Andréa L, Shin, Monica, Kang, Min Su, Li, Xiaofeng, Ba, Maowen, Kandiah, Nagaendran, Rosa-Neto, Pedro, Gauthier, Serge

“…OBJECTIVE:To identify regional brain metabolic dysfunctions associated with neuropsychiatric symptoms (NPS) in preclinical Alzheimer disease (AD). METHODS:We…”
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Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging by Therriault, Joseph, Benedet, Andrea L, Pascoal, Tharick A, Savard, Melissa, Ashton, Nicholas J, Chamoun, Mira, Tissot, Cecile, Lussier, Firoza, Kang, Min Su, Bezgin, Gleb, Wang, Tina, Fernandes-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Zetterberg, Henrik, Blennow, Kaj, Saha-Chaudhuri, Paramita, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

“…Amyloid-β deposition into plaques is a pathologic hallmark of Alzheimer disease appearing years before the onset of symptoms. Although cerebral amyloid-β…”
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Aβ-induced vulnerability propagates via the brain’s default mode network by Pascoal, Tharick A., Mathotaarachchi, Sulantha, Kang, Min Su, Mohaddes, Sara, Shin, Monica, Park, Ah Yeon, Parent, Maxime J., Benedet, Andrea L., Chamoun, Mira, Therriault, Joseph, Hwang, Heungsun, Cuello, A. Claudio, Misic, Bratislav, Soucy, Jean-Paul, Aston, John A. D., Gauthier, Serge, Rosa-Neto, Pedro

“…The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission…”
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Synergistic interaction between amyloid and tau predicts the progression to dementia by Pascoal, Tharick A, Mathotaarachchi, Sulantha, Shin, Monica, Benedet, Andrea L, Mohades, Sara, Wang, Seqian, Beaudry, Tom, Kang, Min Su, Soucy, Jean-Paul, Labbe, Aurelie, Gauthier, Serge, Rosa-Neto, Pedro

“…Abstract Introduction Recent literature proposes that amyloid-β and phosphorylated tau (p-tau) synergism accelerates biomarker abnormalities in controls. Yet,…”
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In vivo quantification of neurofibrillary tangles with [ 18 F]MK-6240 by Pascoal, Tharick A, Shin, Monica, Kang, Min Su, Chamoun, Mira, Chartrand, Daniel, Mathotaarachchi, Sulantha, Bennacef, Idriss, Therriault, Joseph, Ng, Kok Pin, Hopewell, Robert, Bouhachi, Reda, Hsiao, Hung-Hsin, Benedet, Andrea L, Soucy, Jean-Paul, Massarweh, Gassan, Gauthier, Serge, Rosa-Neto, Pedro

“…Imaging agents capable of quantifying the brain's tau aggregates will allow a more precise staging of Alzheimer's disease (AD). The aim of the present study…”
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Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive Individuals by Öhrfelt, Annika, Benedet, Andréa L., Ashton, Nicholas J., Kvartsberg, Hlin, Vandijck, Manu, Weiner, Michael W., Trojanowski, John Q., Shaw, Leslie M., Zetterberg, Henrik, Blennow, Kaj

“…To test the associations between the presynaptic growth-associated protein 43 (GAP-43), quantified in CSF, and biomarkers of Alzheimer disease (AD)…”
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