Search Results - "Beneden, Katrien"

Valproic Acid Attenuates Proteinuria and Kidney Injury by BENEDEN, Katrien Van, GEERS, Caroline, PAUWELS, Marina, MANNAERTS, Inge, VERBEELEN, Dierik, VAN GRUNSVEN, Leo A, DEN BRANDEN, Christiane Van

“…Inhibitors of histone deacetylase (HDAC) have anti-inflammatory and antifibrotic effects in several organs and tissues, but their effect on the progression of…”
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Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria by Garsen, Marjolein, Rops, Angelique L, Li, Jinhua, van Beneden, Katrien, van den Branden, Christiane, Berden, Jo Hm, Rabelink, Ton J, van der Vlag, Johan

“…Endothelial nitric oxide synthase (eNOS) deficiency exacerbates proteinuria and renal injury in several glomerular diseases, but the underlying mechanism is…”
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Analysis of the Nutritional Composition of Ready-to-Use Meat Alternatives in Belgium by Mertens, Evelien, Deriemaeker, Peter, Van Beneden, Katrien

“…The interest in meat alternatives has increased over the years as people embrace more varied food choices because of different reasons. This study aims to…”
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6′-Derivatised α-GalCer Analogues Capable of Inducing Strong CD1d-Mediated Th1-Biased NKT Cell Responses in Mice by Trappeniers, Matthias, Beneden, Katrien Van, Decruy, Tine, Hillaert, Ulrik, Linclau, Bruno, Elewaut, Dirk, Calenbergh, Serge Van

“…α-Galactosyl ceramide (α-GalCer, also known as KRN 7000) is known as the prototypical antigen for invariant natural killer T (NKT) cells. Stimulation of NKT…”
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Adjustments in Food Choices and Physical Activity during Lockdown by Flemish Adults by Mertens, Evelien, Deriemaeker, Peter, Van Beneden, Katrien

“…Background: On Wednesday 18/03/2020 Belgium was placed in lockdown in order to curb the spread of COVID-19. Lockdown can lead to loneliness, boredom, anger,…”
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Integrated safety analysis of filgotinib in patients with moderate-to-severe rheumatoid arthritis over a treatment duration of up to 8.3 years by Burmester, Gerd R, Gottenberg, Jacques-Eric, Caporali, Roberto, Winthrop, Kevin L, Tanaka, Yoshiya, Ekoka Omoruyi, Edmund V, Rajendran, Vijay, Van Hoek, Paul, Van Beneden, Katrien, Takeuchi, Tsutomu, Westhovens, René, Aletaha, Daniel

“…To update the long-term safety profile of filgotinib, a Janus kinase-1 preferential inhibitor, in patients with moderate-to-severe rheumatoid arthritis. Data…”
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Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry by Tilleman, Kelly, Van Beneden, Katrien, Dhondt, Aline, Hoffman, Ilse, De Keyser, Filip, Veys, Eric, Elewaut, Dirk, Deforce, Dieter

“…We investigated the cytosolic proteome of inflamed synovial tissue by hierarchical clustering analysis and validated the feasibility of this proteome analysis…”
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Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29 by Mannaerts, Inge, Eysackers, Nathalie, Onyema, Oscar O, Van Beneden, Katrien, Valente, Sergio, Mai, Antonello, Odenthal, Margarete, van Grunsven, Leo A

“…The conversion of a quiescent vitamin A storing hepatic stellate cell (HSC) to a matrix producing, contractile myofibroblast-like activated HSC is a key event…”
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Treat-to-target in rheumatoid arthritis: a real-world study of the application and impact of treat-to-target within the wider context of patient management, patient centricity and advanced therapy use in Europe by Taylor, Peter C., Fautrel, Bruno, Piette, Yves, Romero-Yuste, Susana, Broen, Jasper, Welcker, Martin, Howell, Oliver, Rottier, Elke, Zignani, Monia, Van Beneden, Katrien, Caporali, Roberto, Alten, Rieke

“…BackgroundWhile treat-to-target (T2T) is endorsed for the management of rheumatoid arthritis (RA), data on the degree of implementation in clinical practice…”
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What benefit–risk trade-offs are acceptable to rheumatoid arthritis patients during treatment selection? Evidence from a multicountry choice experiment by Alten, Rieke, Nieto-Gonzalez, Juan Carlos, Jacques, Peggy, Montecucco, Carlomaurizio, Moots, Robert, Radner, Helga, Vonkeman, Harald E, Heidenreich, Sebastian, Whichello, Chiara, Krucien, Nicolas, Van Beneden, Katrien

“…ObjectiveUnderstanding preferences of patients with rheumatoid arthritis (RA) can facilitate tailored patient-centric care. This study elicited trade-offs that…”
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An anti‐inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation by Rauch, Alexander, Gossye, Valerie, Bracke, Debby, Gevaert, Elien, Jacques, Peggy, Van Beneden, Katrien, Vandooren, Bernard, Rauner, Martina, Hofbauer, Lorenz C., Haegeman, Guy, Elewaut, Dirk, Tuckermann, Jan P., De Bosscher, Karolien

“…ABSTRACT Glucocorticoids (GCs) are in widespread use to treat inflammatory bone diseases, such as rheumatoid arthritis (RA). Their anti‐inflammatory efficacy,…”
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Synthesis and in vitro Evaluation of α-GalCer Epimers by Trappeniers, Matthias, Goormans, Stijn, Van Beneden, Katrien, Decruy, Tine, Linclau, Bruno, Al-Shamkhani, Aymen, Elliott, Tim, Ottensmeier, Christian, Werner, Joern M., Elewaut, Dirk, Van Calenbergh, Serge

“…α‐GalCer (also known as KRN7000) is an immunomodulatory glycolipid that is known to potently activate invariant natural killer T (NKT) cells upon CD1d‐mediated…”
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The Synthesis and in vivo Evaluation of 2′,2′-Difluoro KRN7000 by Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Trappeniers, Matthias, Elewaut, Dirk, Gao, Yifang, Elliott, Tim, Al-Shamkhani, Aymen, Ottensmeier, Christian, Werner, Jörn M., Williams, Anthony, Van Calenbergh, Serge, Linclau, Bruno

“…The synthesis of 2′,2′‐difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d‐dependent TCR activation of…”
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Mapping of the Leptin Binding Sites and Design of a Leptin Antagonist by Peelman, Frank, Van Beneden, Katrien, Zabeau, Lennart, Iserentant, Hannes, Ulrichts, Peter, Defeau, Delphine, Verhee, Annick, Catteeuw, Dominiek, Elewaut, Dirk, Tavernier, Jan

“…The leptin/leptin receptor system shows strong similarities to the long-chain cytokine interleukin-6 (IL-6) and granulocyte colony-stimulating factor…”
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Design of an Optimized Wilms’ Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo by Benteyn, Daphné, Anguille, Sébastien, Van Lint, Sandra, Heirman, Carlo, Van Nuffel, An MT, Corthals, Jurgen, Ochsenreither, Sebastian, Waelput, Wim, Van Beneden, Katrien, Breckpot, Karine, Van Tendeloo, Viggo, Thielemans, Kris, Bonehill, Aude

“…Tumor antigen–encoding mRNA for dendritic cell (DC)-based vaccination has gained increasing popularity in recent years. Within this context, two main…”
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Developmental and Functional Defects of Thymic and Epidermal Vγ3 Cells in IL-15-Deficient and IFN Regulatory Factor-1-Deficient Mice by De Creus, An, Van Beneden, Katrien, Stevenaert, Frederik, Debacker, Veronique, Plum, Jean, Leclercq, Georges

“…In this study, the role of IL-15 and its regulation by the transcription factor IFN regulatory factor-1 (IRF-1) in murine Vγ3 T cell development and activity…”
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P119 The Use of Exposure-Adjusted Event Rates versus Exposure-Adjusted Incidence Rates in Adverse Event Reporting: Insights from Filgotinib Integrated Safety Data in Rheumatoid Arthritis by Durez, Patrick, Feist, Eugen, Blanco, Ricardo, Rajendran, Vijay, Verbruggen, Nadia, Van Beneden, Katrien, Galloway, James

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Expression of Inhibitory Receptors Ly49E and CD94/NKG2 on Fetal Thymic and Adult Epidermal TCR Vγ3 Lymphocytes by Van Beneden, Katrien, De Creus, An, Stevenaert, Frederik, Debacker, Veronique, Plum, Jean, Leclercq, Georges

“…Ly49 and CD94/NKG2 inhibitory receptors are predominantly expressed on murine NK cells, but they are also expressed on a subpopulation of peripheral CD8 memory…”
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A unique lymphotoxin αβ-dependent pathway regulates thymic emigration of Vα14 invariant natural killer T cells by Franki, Ann Sophie, Van Beneden, Katrien, Dewint, Pieter, Hammond, Kirsten J. L., Lambrecht, Stijn, Leclercq, Georges, Kronenberg, Mitchell, Deforce, Dieter, Elewaut, Dirk

“…Natural killer (NK) T cells using an invariant Vα14 (Vα14 i ) T cell receptor rearrangement form a distinct immunoregulatory T cell lineage. Several studies…”
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NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time‐dependent and stochastic manner independently of CD94 and NKG2 by Fraser, Karen P., Gays, Frances, Robinson, John H., Beneden, Katrien van, Leclercq, Georges, Vance, Russell E., Raulet, David H., Brooks, Colin G.

“…NK cells developing in vitro from fetal progenitors in the presence of IL‐2 are phenotypically and functionally indistinguishable from mature adult NK cells,…”
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