Search Results - "Benedeković, Goran"
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Synthesis and antiproliferative activity of (−)-cleistenolide, (6S)-cleistenolide and 4-substituted cleistenolide analogues
Published in Bioorganic & medicinal chemistry (01-09-2024)“…Nineteen new analogues of (−)-cleistenolide were designed, synthesized and evaluated for their in vitro antitumour activity. [Display omitted] •A simple total…”
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2
Asymmetric synthesis and biological evaluation of (+)-cardiobutanolide, (−)-3-deoxycardiobutanolide and analogues as antiproliferative agents
Published in Tetrahedron (24-09-2021)“…Two natural products, (+)-cardiobutanolide and (−)-3-deoxycardiobutanolide, as well as five new analogues, were synthesized in several steps that included…”
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3
Synthesis and antiproliferative activity of (5R)-cleistenolide and analogues
Published in Journal of the Serbian Chemical Society (2023)“…(5R)-Cleistenolide and a few related analogues have been synthesized starting from d-glucose. The key steps of the synthesis included a Z-selective Wittig…”
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The first total synthesis and revision of absolute stereochemistry of natural cytotoxic lactone cleistanolate
Published in Bioorganic chemistry (01-11-2022)“…[Display omitted] •The first total synthesis of the natural product Cleistanolate was achieved.•The proposed structure of the natural product was…”
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Conformationally restricted goniofufurone mimics with halogen, azido or benzoyloxy groups at the C-7 position: Design, synthesis and antiproliferative activity
Published in Tetrahedron (06-09-2018)“…A series of new conformationally restricted goniofufurone mimics, bearing an additional 1,3-dioxan ring and a halogen, azido or benzoyloxy functionality at the…”
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6
New antitumour agents with α,β-unsaturated δ-lactone scaffold: Synthesis and antiproliferative activity of (−)-cleistenolide and analogues
Published in Bioorganic & medicinal chemistry letters (15-07-2016)“…[Display omitted] A stereoselective total synthesis of (−)-cleistenolide (1) from d-glucose has been achieved. This new approach for the synthesis of…”
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Divergent Synthesis of Cytotoxic Styryl Lactones Related to Goniobutenolides A and B, and to Crassalactone D
Published in Organic letters (07-12-2012)“…Goniobutenolides A (1) and B (2), crassalactone D (3), 4-epi-crassalactone D (4), and the corresponding 7-epimers have been synthesized starting from…”
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Novel (−)-goniofufurone mimics: Synthesis, antiproliferative activity and SAR analysis
Published in Journal of the Serbian Chemical Society (2019)“…Divergent syntheses of novel (?)-goniofufurone mimics with an alkoxymethyl group as the side chain have been accomplished from D-glucose in nine synthetic…”
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9
Synthesis and in vitro antitumour activity of crassalactone D, its stereoisomers and novel cinnamic ester derivatives
Published in European journal of medicinal chemistry (07-07-2017)“…Naturally occurring styryl lactone, crassalactone D (1), unnatural 4-epi-crassalactone D (2), and the corresponding 7-epimers (3 and 4) have been synthesized…”
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10
Design, synthesis and SAR analysis of antitumour styryl lactones related to (+)-crassalactones B and C
Published in European journal of medicinal chemistry (24-11-2014)“…A series of styryl lactones containing the cinnamic acid ester groups such as (+)-crassalactones B (3a) and C (4a), 5,7-di-O-cinamoyl derivative 6, the…”
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11
Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position
Published in European journal of medicinal chemistry (10-03-2017)“…A series of new antitumour lactones containing the [3.3.0] bicyclic furano-lactone core and the halogen or azido group at the C-7 position have been designed,…”
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A comparative study of chromatographic behavior and lipophilicity of selected natural styryl lactones, their derivatives and analogues
Published in European journal of pharmaceutical sciences (15-07-2017)“…This study is based on the analyses of the retention behavior of selected natural styryl lactones and their synthetic analogues in reversed-phase…”
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13
Conformationally constrained goniofufurone mimics as inhibitors of tumour cells growth: Design, synthesis and SAR study
Published in European journal of medicinal chemistry (23-07-2014)“…Synthesis of conformationally restricted (+)-goniofufurone (1) and 7-epi-(+)-goniofufurone (2) analogues, with embedded O-isopropylidene, O-methylidene or…”
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14
Synthesis and antiproliferative activity of goniobutenolides A and B, 5-halogenated crassalactone D derivatives and the corresponding 7-epimers
Published in European journal of medicinal chemistry (27-01-2016)“…A new synthesis of goniobutenolides A (1) and B (2) and the corresponding 7-epimers has been achieved starting from diacetone d-glucose. The key step of the…”
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15
Enantiodivergent synthesis of cytotoxic styryl lactones from d-xylose. The first total synthesis of (+)- and (−)-crassalactone C
Published in Tetrahedron (19-12-2009)“…Enantiodivergent total syntheses of both (+)- and (−)-enantiomers of goniofufurone, 7- epi-goniofufurone and crassalactone C have been accomplished starting…”
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16
Heteroannelated and 7-deoxygenated goniofufurone mimics with antitumour activity: Design, synthesis and preliminary SAR studies
Published in Bioorganic & medicinal chemistry letters (15-10-2013)“…Cytotoxic (+)-goniofufurone mimic such as benzoxepane 2 was preferentially formed after the treatment of 7-O-benzoyl-5-O-benzyl (+)-goniofufurone derivative 6…”
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17
Novel goniofufurone and 7-epi-goniofufurone mimics from an unexpected titanium-mediated displacement process
Published in Tetrahedron letters (04-04-2012)“…The synthesis and preliminary antitumour screening of several new goniofufurone mimics bearing chloride and bromide substituents at C-7 are described…”
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18
Heteroannelated (+)-muricatacin mimics: synthesis, antiproliferative properties and structure–activity relationships
Published in Tetrahedron (02-12-2011)“…Six new (+)-muricatacin mimics bearing a furano-furanone core have been synthesized and their in vitro antiproliferative activity was evaluated against a panel…”
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19
Chromatographic lipophilicity and pharmacokinetic behavior of some newly synthesized styryl lactone stereoisomers
Published in Acta Periodica Technologica (01-01-2017)“…The RP-HPLC retention constants of several newly synthesized cytotoxic styryl lactone stereoisomers were determined as parameters of their lipophilicity…”
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20
Synthesis, antiproliferative activity and SAR analysis of (−)-cleistenolide and analogues
Published in European journal of medicinal chemistry (15-09-2020)“…A new, modified total synthesis of (−)-cleistenolide (1) and sixteen new analogues or derivatives was achieved starting from commercially available…”
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