Search Results - "Benedek, George B"

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins by Sinha, Sharmistha, Lopes, Dahabada H. J, Du, Zhenming, Pang, Eric S, Shanmugam, Akila, Lomakin, Aleksey, Talbiersky, Peter, Tennstaedt, Annette, McDaniel, Kirsten, Bakshi, Reena, Kuo, Pei-Yi, Ehrmann, Michael, Benedek, George B, Loo, Joseph A, Klärner, Frank-Gerrit, Schrader, Thomas, Wang, Chunyu, Bitan, Gal

“…Amyloidoses are diseases characterized by abnormal protein folding and self-assembly, for which no cure is available. Inhibition or modulation of abnormal…”
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Phase separation in solutions of monoclonal antibodies and the effect of human serum albumin by Wang, Ying, Lomakin, Aleksey, Latypov, Ramil F, Benedek, George B

“…We report the observation of liquid-liquid phase separation in a solution of human monoclonal antibody, IgG2, and the effects of human serum albumin, a major…”
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Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies by O'Malley, Tiernan T, Oktaviani, Nur Alia, Zhang, Dainan, Lomakin, Aleksey, O'Nuallain, Brian, Linse, Sara, Benedek, George B, Rowan, Michael J, Mulder, Frans A A, Walsh, Dominic M

“…Dimers of Aβ (amyloid β-protein) are believed to play an important role in Alzheimer's disease. In the absence of sufficient brain-derived dimers, we studied…”
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Phase transitions in human IgG solutions by Wang, Ying, Lomakin, Aleksey, Latypov, Ramil F, Laubach, Jacob P, Hideshima, Teru, Richardson, Paul G, Munshi, Nikhil C, Anderson, Kenneth C, Benedek, George B

“…Protein condensations, such as crystallization, liquid-liquid phase separation, aggregation, and gelation, have been observed in concentrated antibody…”
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C-Terminal Turn Stability Determines Assembly Differences between Aβ40 and Aβ42 by Roychaudhuri, Robin, Yang, Mingfeng, Deshpande, Atul, Cole, Gregory M., Frautschy, Sally, Lomakin, Aleksey, Benedek, George B., Teplow, David B.

“…Oligomerization of the amyloid β-protein (Aβ) is a seminal event in Alzheimer's disease. Aβ42, which is only two amino acids longer than Aβ40, is particularly…”
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Quantitative Evaluation of Colloidal Stability of Antibody Solutions using PEG-Induced Liquid–Liquid Phase Separation by Wang, Ying, Latypov, Ramil F, Lomakin, Aleksey, Meyer, Julie A, Kerwin, Bruce A, Vunnum, Suresh, Benedek, George B

“…Colloidal stability of antibody solutions, i.e., the propensity of the folded protein to precipitate, is an important consideration in formulation development…”
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C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity by Fradinger, Erica A, Monien, Bernhard H, Urbanc, Brigita, Lomakin, Aleksey, Tan, Miao, Li, Huiyuan, Spring, Sean M, Condron, Margaret M, Cruz, Luis, Xie, Cui-Wei, Benedek, George B, Bitan, Gal

“…Alzheimer's disease (AD) is an age-related disorder that threatens to become an epidemic as the world population ages. Neurotoxic oligomers of Aβ42 are…”
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Altered phase diagram due to a single point mutation in human γD-crystallin by McManus, Jennifer J, Lomakin, Aleksey, Ogun, Olutayo, Pande, Ajay, Basan, Markus, Pande, Jayanti, Benedek, George B

“…The P23T mutant of human γD-crystallin (HGD) is associated with cataract. We have previously investigated the solution properties of this mutant, as well as…”
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Phase behavior of mixtures of human lens proteins Gamma D and Beta B1 by Wang, Ying, Lomakin, Aleksey, McManus, Jennifer J., Ogun, Olutayo, Benedek, George B.

“…We have experimentally determined the coexistence surface characterizing the phase behavior of γD-βB1-water ternary solutions. The coexistence surface fully…”
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Pathological crystallization of human immunoglobulins by Wang, Ying, Lomakin, Aleksey, Hideshima, Teru, Laubach, Jacob P, Ogun, Olutayo, Richardson, Paul G, Munshi, Nikhil C, Anderson, Kenneth C, Benedek, George B

“…Condensation of Igs has been observed in pharmaceutical formulations and in vivo in cases of cryoglobulinemia. We report a study of monoclonal IgG…”
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Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity by Roychaudhuri, Robin, Zheng, Xueyun, Lomakin, Aleksey, Maiti, Panchanan, Condron, Margaret M, Benedek, George B, Bitan, Gal, Bowers, Michael T, Teplow, David B

“…A variety of species express the amyloid β-protein (Aβ (the term “Aβ” refers both to Aβ40 and Aβ42, whereas “Aβ40” and “Aβ42” refer to each isoform…”
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Mechanistic Investigation of the Inhibition of Aβ42 Assembly and Neurotoxicity by Aβ42 C-Terminal Fragments by Li, Huiyuan, Monien, Bernhard H, Lomakin, Aleksey, Zemel, Reeve, Fradinger, Erica A, Tan, Miao, Spring, Sean M, Urbanc, Brigita, Xie, Cui-Wei, Benedek, George B, Bitan, Gal

“…Oligomeric forms of amyloid β-protein (Aβ) are key neurotoxins in Alzheimer’s disease (AD). Previously, we found that C-terminal fragments (CTFs) of Aβ42…”
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Aeolotopic Interactions of Globular Proteins by Lomakin, Aleksey, Asherie, Neer, Benedek, George B.

“…Protein crystallization, aggregation, liquid-liquid phase separation, and self-assembly are important in protein structure determination in the industrial…”
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Effect of Polyethylene Glycol on the Liquid-Liquid Phase Transition in Aqueous Protein Solutions by Annunziata, Onofrio, Asherie, Neer, Lomakin, Aleksey, Pande, Jayanti, Ogun, Olutayo, Benedek, George B.

“…We have studied the effect of polyethylene glycol (PEG) on the liquid-liquid phase separation (LLPS) of aqueous solutions of bovine γD-crystallin (γD), a…”
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Liquid-Solid Transition in Nuclei of Protein Crystals by Lomakin, Aleksey, Asherie, Neer, Benedek, George B.

“…It is generally assumed that crystallization begins with a small, crystalline nucleus. For proteins this paradigm may not be valid. Our numerical simulations…”
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Kinetic Theory of Fibrillogenesis of Amyloid β -protein by Lomakin, Aleksey, Teplow, David B., Kirschner, Daniel A., Benedek, George B.

“…Prior quasielastic light scattering (QLS) studies of fibrillogenesis of synthetic amyloid β -protein (Aβ )-(1-40) at low pH have suggested a kinetic model in…”
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Structure Determination of Micelle-like Intermediates in Amyloid β-Protein Fibril Assembly by Using Small Angle Neutron Scattering by Yong, Winnie, Lomakin, Aleksey, Kirkitadze, Marina D., Teplow, David B., Chen, Sow-Hsin, Benedek, George B.

“…Increasing evidence supports the hypothesis that amyloid β-protein (Aβ) assembly is a key pathogenic feature of Alzheimer's disease. Thus, understanding the…”
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Liquid–Liquid Phase Separation in Oligomeric Peptide Solutions by Wang, Ying, Lomakin, Aleksey, Kanai, Sonoko, Alex, Rainer, Benedek, George B

“…Oligomeric peptides exist widely in living organisms and play a role in a broad range of biological functions. We report the first observation of liquid–liquid…”
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Temperature Dependence of Amyloid β -Protein Fibrillization by Kusumoto, Yoko, Lomakin, Aleksey, Teplow, David B., Benedek, George B.

“…Fibrillogenesis of the amyloid β -protein (Aβ ) is believed to play a central role in the pathogenesis of Alzheimer's disease. Previous studies of the kinetics…”
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Transformation of Oligomers of Lipidated Peptide Induced by Change in pH by Wang, Ying, Lomakin, Aleksey, Kanai, Sonoko, Alex, Rainer, Benedek, George B

“…Oligomerization of lipidated peptides is of general scientific interest and is important in biomedical and pharmaceutical applications. We investigated the…”
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