Search Results - "Bendzunas, George"

The WASF3-NCKAP1-CYFIP1 Complex Is Essential for Breast Cancer Metastasis by Teng, Yong, Qin, Haiyan, Bahassan, Abdulaziz, Bendzunas, N George, Kennedy, Eileen J, Cowell, John K

“…Inactivation of the WASF3 gene suppresses invasion and metastasis of breast cancer cells. WASF3 function is regulated through a protein complex that includes…”
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Targeting the WASF3 complex to suppress metastasis by Limaye, Ameya J., Whittaker, Matthew K., Bendzunas, George N., Cowell, John K., Kennedy, Eileen J.

“…Wiskott-Aldrich syndrome protein family members (WASF) regulate the dynamics of the actin cytoskeleton, which plays an instrumental role in cancer metastasis…”
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Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC by Whittaker, Matthew K., Bendzunas, George N., Shirani, Mahsa, LeClair, Timothy J., Shebl, Bassem, Dill, Taylor C., Coffino, Philip, Simon, Sanford M., Kennedy, Eileen J.

“…Proteolysis-targeting chimeras (PROTACs) are bifunctional molecules that bind and recruit an E3 ubiquitin ligase to a targeted protein of interest, often…”
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A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A by Manschwetus, Jascha T, Bendzunas, George N, Limaye, Ameya J, Knape, Matthias J, Herberg, Friedrich W, Kennedy, Eileen J

“…Kinases regulate multiple and diverse signaling pathways and misregulation is implicated in a multitude of diseases. Although significant efforts have been put…”
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In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer by Limaye, Ameya J, Bendzunas, George N, Whittaker, Matthew K, LeClair, Timothy J, Helton, Leah G, Kennedy, Eileen J

“…Wiskott-Aldrich Syndrome Protein Family (WASF) members regulate actin cytoskeletal dynamics, and WASF3 is directly associated with breast cancer metastasis and…”
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Targeted disruption of PKC from AKAP signaling complexes by Limaye, Ameya J, Bendzunas, George N, Kennedy, Eileen J

“…Protein Kinase C (PKC) is a member of the AGC subfamily of kinases and regulates a wide array of signaling pathways and physiological processes…”
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Suppression of Breast Cancer Metastasis Using Stapled Peptides Targeting the WASF Regulatory Complex by Cowell, John K, Teng, Yong, Bendzunas, N George, Ara, Roxan, Arbab, Ali S, Kennedy, Eileen J

“…The WASF3 gene facilitates the metastatic phenotype, and its inactivation leads to suppression of invasion and metastasis regardless of the genetic background…”
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Protein kinase inhibitor selectivity “hinges” on evolution by Shrestha, Safal, Bendzunas, George, Kannan, Natarajan

“…In this issue of Structure, Kelso et al. present the crystal structure of the understudied cancer-associated cyclin-dependent kinase 11 (CDK11) bound to the…”
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Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2 by Bendzunas, N. George, Dörfler, Sabrina, Autenrieth, Karolin, Bertinetti, Daniela, Machal, Erik M.F., Kennedy, Eileen J., Herberg, Friedrich W.

“…[Display omitted] Generation of the second messenger molecule cAMP mediates a variety of cellular responses which are essential for critical cellular…”
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Defining A-Kinase Anchoring Protein (AKAP) Specificity for the Protein Kinase A Subunit RI (PKA-RI) by Autenrieth, Karolin, Bendzunas, N. George, Bertinetti, Daniela, Herberg, Friedrich W., Kennedy, Eileen J.

“…A‐Kinase anchoring proteins (AKAPs) act as spatial and temporal regulators of protein kinase A (PKA) by localizing PKA along with multiple proteins into…”
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All Hydrocarbon Stapled Peptides as Allosteric Modulators of Protein-Protein Interactions by Bendzunas, George Nathaniel

“…The ubiquity and variety of protein-protein interactions (PPI) mediating the human protein interactome make them an attractive yet daunting target for…”
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Defining A-KinaseAnchoring Protein (AKAP) Specificity for the Protein KinaseA Subunit RI (PKA-RI) by Autenrieth, Karolin, Bendzunas, N George, Bertinetti, Daniela, Herberg, Friedrich W, Kennedy, Eileen J

“…A-Kinase anchoring proteins (AKAPs) act as spatial and temporal regulators of protein kinaseA (PKA) by localizing PKA along with multiple proteins into…”
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SIDE-CHAIN METALATIONS OF CERTAIN DIMETHYLPYRIDINES BY MEANS OF ORGANOALKALI METAL REAGENTS by BENDZUNAS, STEPHEN GEORGE

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