Search Results - "Bendtzen, K"

Monitoring patients treated with anti-TNF-α biopharmaceuticals: assessing serum infliximab and anti-infliximab antibodies by Svenson, M., Geborek, P., Saxne, T., Bendtzen, K.

“…Objectives. Infliximab is an anti-tumour necrosis factor-α (TNF-α) mouse–human IgG1/κ antibody used to treat patients with rheumatoid arthritis (RA) and other…”
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Letter: can addition of an immunomodulator really reverse antibody formation and loss of response in patients treated with adalimumab? by Bendtzen, K., Steenholdt, C.

“…Linked ContentThis article is linked to Ungar et al and Ben‐Horin et al papers. To view these articles visit https://doi.org/10.1111/apt.13862 and…”
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Monitoring patients treated with anti-TNF-  biopharmaceuticals: assessing serum infliximab and anti-infliximab antibodies by Svenson, M., Geborek, P., Saxne, T., Bendtzen, K.

“…Objectives. Infliximab is an anti-tumour necrosis factor-α (TNF-α) mouse-human IgG1/κ antibody used to treat patients with rheumatoid arthritis (RA) and other…”
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Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis by Radstake, T R D J, Svenson, M, Eijsbouts, A M, van den Hoogen, F H J, Enevold, C, van Riel, P L C M, Bendtzen, K

“…Tumour necrosis factor alpha (TNFalpha) neutralising antibody constructs are increasingly being used to treat rheumatoid arthritis (RA). To determine potential…”
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Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke by Enevold, C., Nielsen, C. H., Molbo, D., Lund, R., Bendtzen, K., Fiehn, N. -E., Holmstrup, P.

“…The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart…”
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Severe infusion reactions to infliximab: aetiology, immunogenicity and risk factors in patients with inflammatory bowel disease by Steenholdt, C., Svenson, M., Bendtzen, K., Thomsen, O. Ø., Brynskov, J., Ainsworth, M. A.

“…Aliment Pharmacol Ther 2011; 34: 51–58 Summary Background  Infliximab (IFX) elicits acute severe infusion reactions in about 5% of patients with inflammatory…”
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Prognostic laboratory markers of joint damage in rheumatoid arthritis by Lindqvist, E, Eberhardt, K, Bendtzen, K, Heinegård, D, Saxne, T

“…Objective: To investigate whether determination of a set of laboratory markers at baseline provides prognostic information on joint damage in hands and feet in…”
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Pre‐existing IgG antibodies cross‐reacting with the Fab region of infliximab predict efficacy and safety of infliximab therapy in inflammatory bowel disease by Steenholdt, C., Palarasah, Y., Bendtzen, K., Teisner, A., Brynskov, J., Teisner, B., Nielsen, C. H.

“…Summary Background Infliximab (IFX) is a chimeric murine/human anti‐TNF antibody (Ab) used for the treatment of Crohn's disease (CD) and ulcerative colitis…”
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Appearance and disappearance of neutralizing antibodies during interferon-beta therapy by SORENSEN, P. Soelberg, KOCH-HENRIKSEN, N, ROSS, C, CLEMMESEN, K. M, BENDTZEN, K

“…Neutralizing antibodies (NABs) occur frequently in patients receiving interferon (IFN)-beta for multiple sclerosis (MS), but it is unclear whether occurrence…”
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Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors by Jørgensen, K T, Wiik, A, Pedersen, M, Hedegaard, C J, Vestergaard, B F, Gislefoss, R E, Kvien, T K, Wohlfahrt, J, Bendtzen, K, Frisch, M

“…To assess the timing of changes in cytokines, cytokine-related markers, autoantibodies and viral antibodies in the pathogenesis of rheumatoid arthritis (RA)…”
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Letter: persistence of anti-infliximab antibodies after discontinuation of infliximab in patients with IBD by Steenholdt, C., Brynskov, J., Bendtzen, K.

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Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease by Steenholdt, C., Enevold, C., Ainsworth, M. A., Brynskov, J., Thomsen, O. Ø., Bendtzen, K.

“…Summary Background Single nucleotide polymorphisms (SNPs) in TNF receptor superfamily (TNFRSF) 1A and 1B, and Fas ligand (FASLG) genes, have been associated…”
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Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus by Enevold, C, Nielsen, C. H, Jacobsen, R. S, Hermansen, M. L. F, Molbo, D, Avlund, K, Bendtzen, K, Jacobsen, S

“…Several studies indicate a role for toll-like receptors (TLRs) in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to investigate the risk of…”
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Serum concentrations of the interferon-γ-inducible chemokine IP-10/CXCl10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease by NICOLETTI, F, CONGET, I, DI MAURO, M, DI MARCO, R, MAZZARINO, M. C, BENDTZEN, K, MESSINA, A, GOMIS, R

“…Chemokines are chemotactic cytokines controlling the recruitment of leukocytes from the blood by regulating integrin adhesiveness. It has been shown that the…”
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Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes by Enevold, C., Kjær, L., Nielsen, C. H., Voss, A., Jacobsen, R. S., Hermansen, M. L. F., Redder, L., Oturai, A. B., Jensen, P. E., Bendtzen, K., Jacobsen, S.

“…This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1…”
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Neutralizing antibodies hamper IFNβ bioactivity and treatment effect on MRI in patients with MS by SORENSEN, P. Soelberg, TSCHERNING, T, MATHIESEN, H. K, LANGKILDE, A. R, ROSS, C, RAVNBORG, M, BENDTZEN, K

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Lower limb ischaemia and reperfusion injury in healthy volunteers measured by oxidative and inflammatory biomarkers by Halladin, NL, Ekeløf, S, Alamili, M, Bendtzen, K, Lykkesfeldt, J, Rosenberg, J, Gögenur, I

“…Objective: Ischaemia-reperfusion (IR) injury is partly caused by the release of reactive oxygen species and cytokines and may result in remote organ injury…”
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Specific and Strain-Independent Effects of Dexamethasone in the Prevention and Treatment of Experimental Autoimmune Encephalomyelitis in Rodents by Donia, M, Mangano, K, Quattrocchi, C, Fagone, P, Signorelli, S, Magro, G, Sfacteria, A, Bendtzen, K, Nicoletti, F

“…Experimental autoimmune encephalomyelitis in rodents (EAE) is a generally accepted in vivo model for immunopathogenic mechanisms underlying multiple sclerosis…”
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Commentary: antibodies reacting with the infliximab Fab portion – something new? Authors' reply by Nielsen, C. H., Steenholdt, C., Palarasah, Y., Bendtzen, K., Teisner, A., Brynskov, J., Teisner, B.

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The clinical effect of neutralizing antibodies against interferon-beta is independent of the type of interferon-beta used for patients with relapsing-remitting multiple sclerosis by Koch-Henriksen, N, Sorensen, PS, Bendtzen, K, Flachs, EM

“…Objective To establish whether the clinical effect of neutralizing antibodies (NAbs) against interferon-beta (IFNβ) depends on the type of IFNβ (1a or 1b) used…”
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