An Abbreviated Caries Clinical Trial Design Validated over 24 Months

Conventional caries trials last from 24 to 36 months. This study evaluated whether the previously established difference in efficacy between 1000- and 2500-ppm-fluoride dentifrices could be detected after 12 months. Caries was assessed by clinical visual assessment (CVA-simplified version of Dundee...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of dental research Vol. 81; no. 9; pp. 637 - 640
Main Authors:	Chesters, R.K., Pitts, N.B., Matuliene, G., Kvedariene, A., Huntington, E., Bendinskaite, R., Balciuniene, I., Matheson, J.R., Nicholson, J.A., Gendvilyte, A., Sabalaite, R., Ramanauskiene, J., Savage, D., Mileriene, J.
Format:	Journal Article
Language:	English
Published:	United States SAGE Publications 01-09-2002 SAGE PUBLICATIONS, INC
Subjects:	Adolescent Analysis of Variance Cariostatic Agents - administration & dosage Cariostatic Agents - therapeutic use Child Dental Caries - diagnosis Dental Caries - physiopathology Dental Caries - prevention & control Dental Caries Susceptibility Dental Enamel - pathology Dental Restoration, Permanent Dentifrices - therapeutic use Dentin - pathology Dentistry Disease Progression DMF Index Double-Blind Method Female Fluorides - administration & dosage Fluorides - therapeutic use Follow-Up Studies Humans Male Observer Variation Radiography, Bitewing Reproducibility of Results Research Design Statistics as Topic Tooth Extraction Tooth Remineralization Transillumination Treatment Outcome digital radiography fiber optic transillumination clinical visual assessment caries clinical trials Dundee Selectable Threshold Method
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Conventional caries trials last from 24 to 36 months. This study evaluated whether the previously established difference in efficacy between 1000- and 2500-ppm-fluoride dentifrices could be detected after 12 months. Caries was assessed by clinical visual assessment (CVA-simplified version of Dundee Selectable Threshold Method - DSTM), bitewing radiography, and Fiber Optic Transillumination (FOTI). Changes in status for individual surfaces were classified by means of pre-prepared matrices as 0 (unchanged), +1 (initiation or progression), or -1 (regression) and summed for each subject to yield an event score. Mean group event scores were calculated for each product. DSTM at the D1 [enamel and dentin] threshold showed significant inter-group differences in mean event scores (p < 0.003) and D1MFS increment (< 0.007) at 12 months; these were confirmed at 24 months by traditional increment analysis (CVA & FOTI at the D3 (dentin only) threshold + radiography, p < 0.03). This study confirms the validity of an abbreviated trial protocol.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	0022-0345 1544-0591
DOI:	10.1177/154405910208100912