Search Results - "Bendesky, Lauren"

Differential Effects of TLR1/2 and TLR2/6 Signaling on Normal and Premalignant Hematopoietic Stem and Progenitor Cells by Monlish, Darlene A., Greenberg, Zev J., Bhatt, Sima T., Ralphs, Dagmar, Keller, John L., Bendesky, Lauren, Schuettpelz, Laura G.

“…Prior studies from our lab and others have demonstrated a role for Toll-like receptor 2 (TLR2) in regulating both normal and premalignant hematopoietic stem…”
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TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98–HOXD13 mouse model of MDS by Monlish, Darlene A., Greenberg, Zev J., Bhatt, Sima T., Leonard, Kathryn M., Romine, Molly P., Dong, Qian, Bendesky, Lauren, Duncavage, Eric J., Magee, Jeffrey A., Schuettpelz, Laura G.

“…•Chronic stimulation of TLR2/6, but not TLR1/2, accelerates leukemic transformation in the NHD13 mouse model of MDS.•Conversely, loss of TLR6, but not TLR1,…”
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