Search Results - "Bender, Sabine"

Secretome Signature Identifies ADAM17 as Novel Target for Radiosensitization of Non-Small Cell Lung Cancer by Sharma, Ashish, Bender, Sabine, Zimmermann, Martina, Riesterer, Oliver, Broggini-Tenzer, Angela, Pruschy, Martin N

“…Ionizing radiation (IR) induces intracellular signaling processes as part of a treatment-induced stress response. Here we investigate IR-induced ADAM17…”
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Fenretinide Acts as Potent Radiosensitizer for Treatment of Rhabdomyosarcoma Cells by Brack, Eva, Bender, Sabine, Wachtel, Marco, Pruschy, Martin, Schäfer, Beat W.

“…Fusion-positive rhabdomyosarcoma (FP-RMS) is a highly aggressive childhood malignancy which is mainly treated by conventional chemotherapy, surgery and…”
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Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants by Dächert, Christopher, Muenchhoff, Maximilian, Graf, Alexander, Autenrieth, Hanna, Bender, Sabine, Mairhofer, Helga, Wratil, Paul R., Thieme, Susanne, Krebs, Stefan, Grzimek-Koschewa, Natascha, Blum, Helmut, Keppler, Oliver T.

“…On November 26, 2021, the World Health Organization classified B.1.1.529 as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern…”
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The hypoxia-activated prodrug evofosfamide in combination with multiple regimens of radiotherapy by Nytko, Katarzyna J, Grgic, Ivo, Bender, Sabine, Ott, Janosch, Guckenberger, Matthias, Riesterer, Oliver, Pruschy, Martin

“…The promising treatment combination of ionizing radiation (IR) with a hypoxia-activated prodrug (HAP) is based on biological cooperation. Here we investigated…”
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An MRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth by Young, Lucy C., Hartig, Nicole, Muñoz-Alegre, Marta, Oses-Prieto, Juan A., Durdu, Sevi, Bender, Sabine, Vijayakumar, Vineetha, Vietri Rudan, Matteo, Gewinner, Christina, Henderson, Stephen, Jathoul, Amit P., Ghatrora, Rupinder, Lythgoe, Mark F., Burlingame, Alma L., Rodriguez-Viciana, Pablo

“…SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-MAPK pathway, which is upregulated in the majority of human cancers…”
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Consolidation cetuximab after concurrent triplet radiochemotherapy+cetuximab in patients with advanced head and neck cancer: A randomized phase II study by Riesterer, Oliver, Pruschy, Martin, Bender, Sabine, Sharma, Ashish, Bogowicz, Marta, Tanadini-Lang, Stephanie, Stieb, Sonja, Bertogg, Kaja, Weber, Sandra, Ikenberg, Kristian, Huber, Gerhard, Schmid, Stephan, Bredell, Marius, Veit-Haibach, Patrick, Rordorf, Tamara, Held, Ulrike, Glanzmann, Christoph, Studer, Gabriela

“…•Consolidation cetuximab after concurrent triplet radiochemotherapy+cetuximab did not improve the 2-year locoregional control (LRC) rate.•Toxicity was similar…”
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The ADAM17-directed Inhibitory Antibody MEDI3622 Antagonizes Radiotherapy-induced VEGF Release and Sensitizes Non-Small Cell Lung Cancer for Radiotherapy by Tschanz, Fabienne, Bender, Sabine, Telarovic, Irma, Waller, Verena, Speck, Roberto F, Pruschy, Martin

“…The cellular response to ionizing radiation (IR) depends on tumor cell and microenvironmental factors. Here, we investigated the role of IR-induced ADAM17…”
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Combined treatment strategies for microtubule stabilizing agent-resistant tumors by Broggini-Tenzer, Angela, Sharma, Ashish, Nytko, Katarzyna J, Bender, Sabine, Vuong, Van, Orlowski, Katrin, Hug, Daniel, O'Reilly, Terence, Pruschy, Martin

“…Resistance to microtubule-stabilizing agents is a major hurdle for successful cancer therapy. We investigated combined treatment of microtubule-stabilizing…”
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Genomic epidemiology reveals multiple introductions of SARS-CoV-2 followed by community and nosocomial spread, Germany, February to May 2020 by Muenchhoff, Maximilian, Graf, Alexander, Krebs, Stefan, Quartucci, Caroline, Hasmann, Sandra, Hellmuth, Johannes C, Scherer, Clemens, Osterman, Andreas, Boehm, Stephan, Mandel, Christopher, Becker-Pennrich, Andrea Sabine, Zoller, Michael, Stubbe, Hans Christian, Munker, Stefan, Munker, Dieter, Milger, Katrin, Gapp, Madeleine, Schneider, Stephanie, Ruhle, Adrian, Jocham, Linda, Nicolai, Leo, Pekayvaz, Kami, Weinberger, Tobias, Mairhofer, Helga, Khatamzas, Elham, Hofmann, Katharina, Spaeth, Patricia M, Bender, Sabine, Kääb, Stefan, Zwissler, Bernhard, Mayerle, Julia, Behr, Juergen, von Bergwelt-Baildon, Michael, Reincke, Martin, Grabein, Beatrice, Hinske, Christian Ludwig, Blum, Helmut, Keppler, Oliver T

“…Background In the SARS-CoV-2 pandemic, viral genomes are available at unprecedented speed, but spatio-temporal bias in genome sequence sampling precludes…”
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Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages by Osterman, Andreas, Krenn, Franziska, Iglhaut, Maximilian, Badell, Irina, Lehner, Andreas, Späth, Patricia M., Stern, Marcel, Both, Hanna, Bender, Sabine, Muenchhoff, Maximilian, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Grimmer, Timo, Durner, Jürgen, Czibere, Ludwig, Dächert, Christopher, Grzimek-Koschewa, Natascha, Protzer, Ulrike, Kaderali, Lars, Baldauf, Hanna-Mari, Keppler, Oliver T.

“…Diagnostic tests for direct pathogen detection have been instrumental to contain the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)…”
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Abstract C145: Targeted radiosensitization of non-small cell lung cancer (NSCLC) through ADAM17 inhibition by Sharma, Ashish, Bender, Sabine, Riesterer, Oliver, Broggini-Tenzer, Angela, Pruschy, Martin

“…Abstract Introduction: Radiotherapy is a mainstay for the treatment of locally advanced NSCLC. However, the response rates and clinical outcomes are still…”
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Abstract A185: Combined treatment strategies for microtubule interfering agent-resistant tumors by Broggini-Tenzer, Angela, Sharma, Ashish, Bender, Sabine, Nytko-Karouzakis, Katarzyna, Pruschy, Martin

“…Abstract Treatment resistances to specific anticancer agents and radiotherapy are often linked to the mutated genetic background of tumor cells. Their…”
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Abstract 4045: MRAS and SHOC2 interact with SCRIB and coordinate ERK pathway activation with polarity and tumorigenic growth by Young, Lucy C., Hartig, Nicole, Munoz-Alegre, Marta, Oses-Prieto, Juan A., Durdu, Sevi, Bender, Sabine, Vijakumar, Vineetha, Vietri Rudan, Matteo, Gewinner, Christina, Jathoul, Amit P., Ghatrora, Rupinder, Lythgoe, Mark L., Burlingame, Alma L., Rodriguez-Viciana, Pablo

“…Abstract SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-MAPK pathway, which is upregulated in the majority of human…”
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Abstract A22: An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth by Young, Lucy C., Hartig, Nicole, Munoz-Alegre, Marta, Oses-Prieto, Juan A., Durdu, Sevi, Bender, Sabine, Vijayakumar, Vineetha, Rudan, Matteo Vietri, Gewinner, Christina, Henderson, Stephen, Jathoul, Amit P., Ghatrora, Rupinder, Lythgoe, Mark F., Burlingame, Alma L., Rodriguez-Viciana, Pablo

“…Abstract SHOC2 is mutated in Noonan syndrome and plays a key role in the activation of the ERK-MAPK pathway, which is upregulated in the majority of human…”
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Methodical influence on selected parameters of the acid-base equilibrium in urine samples from dairy cows by Bender, Sabine, Staufenbiel, Rudolf

“…Estimation of net acid base excretion (NABE) in urine samples of dairy cows has often been reported in the veterinary literature. NABE has been proved to be…”
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