Search Results - "Bender, Clare"

The two pore potassium channel THIK‐1 regulates NLRP3 inflammasome activation by Drinkall, Samuel, Lawrence, Catherine B., Ossola, Bernadino, Russell, Samuel, Bender, Clare, Brice, Nicola B., Dawson, Lee A., Harte, Michael, Brough, David

“…The NLRP3 (NLR family, pyrin domain containing 3) inflammasome is a multi‐protein complex responsible for the activation of caspase‐1 and the subsequent…”
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Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome by Ossola, Bernardino, Rifat, Ali, Rowland, Anna, Hunter, Helen, Drinkall, Samuel, Bender, Clare, Hamlischer, Mayida, Teall, Martin, Burley, Russell, Barker, Daneil F., Cadwalladr, David, Dickson, Louise, Lawrence, Jason M.K., Harvey, Jenna R.M., Lizio, Marina, Xu, Xiao, Kavanagh, Edel, Cheung, Toni, Sheardown, Steve, Lawrence, Catherine B., Harte, Michael, Brough, David, Madry, Christian, Matthews, Kim, Doyle, Kevin, Page, Keith, Powell, Justin, Brice, Nicola L., Bürli, Roland W., Carlton, Mark B., Dawson, Lee A.

“…Neuroinflammation, specifically the NLRP3 inflammasome cascade, is a common underlying pathological feature of many neurodegenerative diseases. Evidence…”
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Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators by Burley, Russell, Hewer, Richard C., Teall, Martin, Dickson, Louise, Ossola, Bernardino, Russell, Sam, Bender, Clare, Cheung, Toni, Powell, Justin A.C., Xu, Xiao, Brice, Nicola L., Otter, Lucy, Arimont, Marta, Kidd, Sarah L., Vidal, David, Dale, James W., Mervin, Lewis, Sore, Hannah F., Mateu, Natalia, Lakshminarayana, Narayana, Dawson, Lee A., Carlton, Mark, Bürli, Roland W.

“…[Display omitted] We report a significant decrease in transcription of the G protein-coupled receptor GPR39 in striatal neurons of Parkinson’s disease patients…”
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A high utility integrated map of the pig genome by Humphray, Sean J, Scott, Carol E, Clark, Richard, Marron, Brandy, Bender, Clare, Camm, Nick, Davis, Jayne, Jenks, Andrew, Noon, Angela, Patel, Manish, Sehra, Harminder, Yang, Fengtang, Rogatcheva, Margarita B, Milan, Denis, Chardon, Patrick, Rohrer, Gary, Nonneman, Dan, de Jong, Pieter, Meyers, Stacey N, Archibald, Alan, Beever, Jonathan E, Schook, Lawrence B, Rogers, Jane

“…The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein…”
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