Application of amniotic membranes in reconstructive surgery of internal organs—A systematic review and meta‐analysis

Application of amniotic membranes in reconstructive surgery of internal organs—A systematic review and meta‐analysis

Amniotic membrane (AM) has great potential as a scaffold for tissue regeneration in reconstructive surgery. To date, no systematic review of the literature has been performed for the applications of AM in wound closure of internal organs. Therefore, in this systematic review and meta‐analysis, we su...

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Bibliographic Details
Published in:Journal of tissue engineering and regenerative medicine Vol. 16; no. 12; pp. 1069 - 1090
Main Authors: Maljaars, Lennart P., Bendaoud, Sohayla, Kastelein, Arnoud W., Guler, Zeliha, Hooijmans, Carlijn R., Roovers, Jan‐Paul W. R.
Format: Journal Article
Language:English
Published: England Hindawi Limited 01-12-2022
John Wiley and Sons Inc
Subjects:
Amnion
Amniotic membrane
animal models
Bias
Clinical trials
Complications
Effectiveness
hollow organ repair
human studies
Humans
internal organs
Literature reviews
Mechanical properties
Membranes
Meta-analysis
Mortality
Organs
Plastic surgery
Plastic Surgery Procedures
Reconstructive surgery
Regeneration (physiology)
Regenerative medicine
Review
surgical repair
Systematic review
Tissue engineering
Wound Closure Techniques
Wound Healing
animal models
wound healing
amniotic membrane
surgical repair
hollow organ repair
internal organs
human studies
reconstructive surgery
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Summary:Amniotic membrane (AM) has great potential as a scaffold for tissue regeneration in reconstructive surgery. To date, no systematic review of the literature has been performed for the applications of AM in wound closure of internal organs. Therefore, in this systematic review and meta‐analysis, we summarize the literature on the safety and efficacy of AM for the closure of internal organs. A systematic search was performed in MEDLINE‐PubMed database and OVID Embase to retrieve human and controlled animal studies on wound closure of internal organs. The Cochrane Risk of Bias tool for randomized clinical trials and the SYRCLE risk of bias tool for animal studies were used. Meta‐analyses (MAs) were conducted for controlled animal studies to assess efficacy of closure, mortality and complications in subjects who underwent surgical wound closure in internal organs with the application of AM. Sixty references containing 26 human experiments and 36 animal experiments were included. The MAs of the controlled animal studies showed comparable results with regard to closure, mortality and complications, and suggested improved mechanical strength and lower inflammation scores after AM application when compared to standard surgical closure techniques. This systematic review and MAs demonstrate that the application of AM to promote wound healing of internal organs appears to be safe, efficacious, and feasible.
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ISSN:1932-6254
1932-7005
DOI:10.1002/term.3357