Search Results - "Bench, A."

KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype by Clipson, A, Wang, M, de Leval, L, Ashton-Key, M, Wotherspoon, A, Vassiliou, G, Bolli, N, Grove, C, Moody, S, Escudero-Ibarz, L, Gundem, G, Brugger, K, Xue, X, Mi, E, Bench, A, Scott, M, Liu, H, Follows, G, Robles, E F, Martinez-Climent, J A, Oscier, D, Watkins, A J, Du, M-Q

“…To characterise the genetics of splenic marginal zone lymphoma (SMZL), we performed whole exome sequencing of 16 cases and identified novel recurrent…”
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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders by BAXTER, E, SCOTT, L, CAMPBELL, P, EAST, C, FOUROUCLAS, N, SWANTON, S, VASSILIOU, G, BENCH, A, BOYD, E, CURTIN, N

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Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM0902) study by Jovanovic, J V, Ivey, A, Vannucchi, A M, Lippert, E, Oppliger Leibundgut, E, Cassinat, B, Pallisgaard, N, Maroc, N, Hermouet, S, Nickless, G, Guglielmelli, P, van der Reijden, B A, Jansen, J H, Alpermann, T, Schnittger, S, Bench, A, Tobal, K, Wilkins, B, Cuthill, K, McLornan, D, Yeoman, K, Akiki, S, Bryon, J, Jeffries, S, Jones, A, Percy, M J, Schwemmers, S, Gruender, A, Kelley, T W, Reading, S, Pancrazzi, A, McMullin, M F, Pahl, H L, Cross, N C P, Harrison, C N, Prchal, J T, Chomienne, C, Kiladjian, J J, Barbui, T, Grimwade, D

“…Reliable detection of JAK2 -V617F is critical for accurate diagnosis of myeloproliferative neoplasms (MPNs); in addition, sensitive mutation-specific assays…”
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MARIMO cells harbor a CALR mutation but are not dependent on JAK2/STAT5 signaling by Kollmann, K, Nangalia, J, Warsch, W, Quentmeier, H, Bench, A, Boyd, E, Scott, M, Drexler, H G, Green, A R

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The role of molecular genetic analysis within the diagnostic haemato-oncology laboratory by BENCH, A. J.

“…Summary The identification of the molecular genetic basis to many haematological malignancies along with the increased use of molecularly targeted therapy has…”
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Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture by Conte, N, Varela, I, Grove, C, Manes, N, Yusa, K, Moreno, T, Segonds-Pichon, A, Bench, A, Gudgin, E, Herman, B, Bolli, N, Ellis, P, Haddad, D, Costeas, P, Rad, R, Scott, M, Huntly, B, Bradley, A, Vassiliou, G S

“…Advances in sequencing technologies are giving unprecedented insights into the spectrum of somatic mutations underlying acute myeloid leukaemia with a normal…”
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Large deletions at the t(9;22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia by Sinclair, P.B., Nacheva, E.P., Leversha, M., Telford, N., Chang, J., Reid, A., Bench, A., Champion, K., Huntly, B., Green, A.R.

“…The hallmark of chronic myeloid leukemia (CML) is theBCR-ABL fusion gene, which is usually formed as a result of the t(9;22) translocation. Patients with CML…”
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Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation by Campbell, Peter J., Baxter, E. Joanna, Beer, Philip A., Scott, Linda M., Bench, Anthony J., Huntly, Brian J.P., Erber, Wendy N., Kusec, Rajko, Larsen, Thomas Stauffer, Giraudier, Stéphane, Le Bousse-Kerdilès, Marie-Caroline, Griesshammer, Martin, Reilly, John T., Cheung, Betty Y., Harrison, Claire N., Green, Anthony R.

“…The identification of an acquired mutation of JAK2 in patients with myeloproliferative disorders has raised questions about the relationship between…”
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Modeling Fibrillogenesis of Collagen-Mimetic Molecules by Hafner, Anne E., Gyori, Noemi G., Bench, Ciaran A., Davis, Luke K., Šarić, Anđela

“…One of the most robust examples of self-assembly in living organisms is the formation of collagen architectures. Collagen type I molecules are a crucial…”
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Analysis of vertebrate SCL loci identifies conserved enhancers by Green, Anthony R, Göttgens, Berthold, Barton, Linda M, Gilbert, James G.R, Bench, Anthony J, Sanchez, Maria-José, Bahn, Sabine, Mistry, Shailesh, Grafham, Darren, McMurray, Amanda, Vaudin, Mark, Amaya, Enrique, Bentley, David R

“…The SCL gene encodes a highly conserved bHLH transcription factor with a pivotal role in hemopoiesis and vasculogenesis. We have sequenced and analyzed 320 kb…”
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Chromosome 20 deletions in myeloid malignancies : reduction of the common deleted region, generation of a PAC/BAC contig and identification of candidate genes by BENCH, A. J, NACHEVA, E. P, HUNT, A. R, HUNTLY, B. J. P, CAMPBELL, L. J, BENTLEY, D. R, DELOUKAS, P, GREEN, A. R, HOOD, T. L, HOLDEN, J. L, FRENCH, L, SWANTON, S, CHAMPION, K. M, LI, J, WHITTAKER, P, STAVRIDES, G

“…Deletion of the long arm of chromosome 20 represents the most common chromosomal abnormality associated with the myeloproliferative disorders (MPDs) and is…”
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Spectroscopy and Electronic Structure of Electron Deficient Zinc Phthalocyanines by Keizer, Steven P, Mack, John, Bench, Barbara A, Gorun, Sergiu M, Stillman, Martin J

“…The effect of introduction of perfluoro alkyl groups into phthalocyanines, as evidenced by the spectroscopic properties of…”
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Introduction of Bulky Perfluoroalkyl Groups at the Periphery of Zinc Perfluorophthalocyanine: Chemical, Structural, Electronic, and Preliminary Photophysical and Biological Effects by Bench, Barbara A., Beveridge, Andrew, Sharman, Wesley M., Diebold, Gerald J., van Lier, Johan E., Gorun, Sergiu M.

“…A higher anticancer activity is observed in photodynamic tests with the first sterically bulky (nonplanar) perhalogenated zinc phthalocyanine (Pc),…”
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Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia by Huntly, Brian J.P., Reid, Alistair G., Bench, Anthony J., Campbell, Lynda J., Telford, Nick, Shepherd, Patricia, Szer, Jeff, Prince, H. Miles, Turner, Paul, Grace, Colin, Nacheva, Elizabeth P., Green, Anthony R.

“…Chronic myeloid leukemia (CML) is characterized by formation of theBCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between…”
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Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders by Fourouclas, Nasios, Li, Juan, Gilby, Daniel C, Campbell, Peter J, Beer, Philip A, Boyd, Elaine M, Goodeve, Anne C, Bareford, David, Harrison, Claire N, Reilly, John T, Green, Anthony R, Bench, Anthony J

“…1 University of Cambridge, Department of Haematology, Cambridge Institute for Medical Research, Cambridge 2 Academic Unit of Haematology, School of Medicine…”
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Molecular genetic analysis of haematological malignancies II: mature lymphoid neoplasms by BENCH, A. J., ERBER, W. N., FOLLOWS, G. A., SCOTT, M. A.

“…Summary Molecular genetic techniques have become an integral part of the diagnostic assessment for many lymphomas and other chronic lymphoid neoplasms. The…”
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Therapy-related acute myeloid leukaemia with t(8;16)(p11;p13);MOZ-CBP and polymorphisms in detoxifying and DNA repair genes by Boyd, E M, Bench, A J, Vaghela, K J, Campbell, G N, Chowdhury, F B, Gudgin, E J, Scott, M A, Erber, W N

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Distinct 5′ SCL Enhancers Direct Transcription to Developing Brain, Spinal Cord, and Endothelium: Neural Expression Is Mediated by GATA Factor Binding Sites by Sinclair, A.M., Göttgens, B., Barton, L.M., Stanley, M.L., Pardanaud, L., Klaine, M., Gering, M., Bahn, S., Sanchez, M.-J., Bench, A.J., Fordham, J.L., Bockamp, E.-O., Green, A.R.

“…The SCL gene encodes a basic helix-loop-helix transcription factor with a pivotal role in the development of endothelium and of all hematopoietic lineages. SCL…”
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Molecular genetic analysis of haematological malignancies: I. Acute leukaemias and myeloproliferative disorders by BENCH, A. J., ERBER, W. N., SCOTT, M. A.

“…Summary Molecular genetic techniques are now routinely applied to haematological malignancies within a clinical laboratory setting. The detection of genetic…”
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Synthesis and Structure of a Biconcave Cobalt Perfluorophthalocyanine and Its Catalysis of Novel Oxidative Carbon-Phosphorus Bonds Formation by Using Air by Bench, Barbara A., Brennessel, William W., Lee, Hyun-Jin, Gorun, Sergiu M.

“…An enzyme‐inspired phthalocyanine (Pc) complex [F64PcCo(acetone)2] is the first representative of a novel class of robust homogeneous catalysts. This complex…”
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