Primary Sjögren's syndrome in men

Primary Sjögren's syndrome in men

Objective: To determine whether there were any clinical and biological differences between male and female patients with primary Sjögren's syndrome (pSS) in a large bicentric series of patient. Methods: We studied 419 consecutive patients (mean age at onset 53.6 years, mean disease outcome 73 m...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology Vol. 37; no. 4; pp. 300 - 305
Main Authors: Gondran, G., Fauchais, A. L., Lambert, M., Ly, K., Launay, D., Queyrel, V., Benazahari, H., Liozon, E., Loustaud-Ratti, V., Hachulla, E., Jauberteau, M. O., Hatron, P. Y., Vidal, E.
Format: Journal Article
Language:English
Published: Colchester Informa UK Ltd 01-01-2008
Taylor & Francis
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Diseases of the osteoarticular system
Endocrinology and metabolism
Female
Follow-Up Studies
Human health and pathology
Humans
Life Sciences
Male
Medical sciences
Middle Aged
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sex Factors
Sjogren's Syndrome
Sjogren's Syndrome - physiopathology
Human
Immunopathology
Eye disease
Stomatology
Systemic disease
Rheumatology
Autoimmune disease
Sjögren syndrome
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Summary:Objective: To determine whether there were any clinical and biological differences between male and female patients with primary Sjögren's syndrome (pSS) in a large bicentric series of patient. Methods: We studied 419 consecutive patients (mean age at onset 53.6 years, mean disease outcome 73 months) with pSS according to American-European criteria, attending two different Departments of Internal Medicine in France. The 42 (9%) male patients in this cohort comprised the male group described in this study. Results: Extraglandular manifestations during the course of the disease were present in 37 (89%) of our male patients with pSS. The extraglandular manifestations were similar among the two groups except that the male patients showed a lower frequency of depression or asthaenia (5% vs. 20%, p = 0.014) compared with the females. A significantly greater percentage of women reported lymphopaenia (26% vs. 8%, p = 0.02) and leucopaenia (18% vs. 3%, p = 0.015) at onset, but thrombopaenia was more common in the male patients (21% vs. 6%, p = 0.001). Lymphoma development was slightly more common in the male patients, but with no statistical significance (10% vs. 3%, p = 0.06), and occurred earlier after the SS diagnosis (log rank test p = 0.04). Conclusion: Although pSS is typically a disease affecting women, clinicians should be aware that it may be diagnosed in male patients. Except for haematological presentation, we could not find any notable differences in clinical and immunological characteristics between male and female patients with pSS.
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ISSN:0300-9742
1502-7732
DOI:10.1080/03009740802001426