Search Results - "Benayoun, Bérénice A."

Epigenetic regulation of ageing: linking environmental inputs to genomic stability by Benayoun, Bérénice A., Pollina, Elizabeth A., Brunet, Anne

“…Key Points Widespread epigenomic remodelling, at the level of DNA or histone protein modification, has been observed during ageing across species and cell…”
Get full text

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress by Kim, Kyung Hwa, Son, Jyung Mean, Benayoun, Bérénice A., Lee, Changhan

“…Cellular homeostasis is coordinated through communication between mitochondria and the nucleus, organelles that each possess their own genomes. Whereas the…”
Get full text

Forkhead transcription factors: key players in health and disease by Benayoun, Bérénice A, Caburet, Sandrine, Veitia, Reiner A

“…Forkhead box (FOX) proteins constitute an evolutionarily conserved family of transcription factors with a central role not only during development, but also in…”
Get full text

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses by Benayoun, Bérénice A, Pollina, Elizabeth A, Singh, Param Priya, Mahmoudi, Salah, Harel, Itamar, Casey, Kerriann M, Dulken, Ben W, Kundaje, Anshul, Brunet, Anne

“…Aging is accompanied by the functional decline of tissues. However, a systematic study of epigenomic and transcriptomic changes across tissues during aging is…”
Get full text

H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency by Benayoun, Bérénice A., Pollina, Elizabeth A., Ucar, Duygu, Mahmoudi, Salah, Karra, Kalpana, Wong, Edith D., Devarajan, Keerthana, Daugherty, Aaron C., Kundaje, Anshul B., Mancini, Elena, Hitz, Benjamin C., Gupta, Rakhi, Rando, Thomas A., Baker, Julie C., Snyder, Michael P., Cherry, J. Michael, Brunet, Anne

“…Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to mark the transcription start sites of active genes. Here, we show that…”
Get full text

Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models by Chen, Yilin, Kim, Minhoo, Paye, Sanjana, Benayoun, Bérénice A

“…Biological sex is a fundamental source of phenotypic variability across species. Males and females have different nutritional needs and exhibit differences in…”
Get full text

A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate by Harel, Itamar, Benayoun, Bérénice A., Machado, Ben, Singh, Param Priya, Hu, Chi-Kuo, Pech, Matthew F., Valenzano, Dario Riccardo, Zhang, Elisa, Sharp, Sabrina C., Artandi, Steven E., Brunet, Anne

“…Aging is a complex process that affects multiple organs. Modeling aging and age-related diseases in the lab is challenging because classical vertebrate models…”
Get full text

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans by Greer, Eric L., Maures, Travis J., Ucar, Duygu, Hauswirth, Anna G., Mancini, Elena, Lim, Jana P., Benayoun, Bérénice A., Shi, Yang, Brunet, Anne

“…Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be…”
Get full text

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis by Reynolds, Joseph C., Lai, Rochelle W., Woodhead, Jonathan S. T., Joly, James H., Mitchell, Cameron J., Cameron-Smith, David, Lu, Ryan, Cohen, Pinchas, Graham, Nicholas A., Benayoun, Bérénice A., Merry, Troy L., Lee, Changhan

“…Healthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief metabolic organelles with strong implications in…”
Get full text

MOTS‐c: A Mitochondrial‐Encoded Regulator of the Nucleus by Benayoun, Bérénice A., Lee, Changhan

“…Mitochondria are increasingly being recognized as information hubs that sense cellular changes and transmit messages to other cellular components, such as the…”
Get full text

Putting aging on ICE by Teefy, Bryan B., Benayoun, Bérénice A.

“…A recent report by Yang et al. in Cell demonstrates that faithful DNA double-strand breaks and repair cycles phenocopy many aspects of aging in mice. Whether…”
Get full text

Males Shorten the Life Span of C. elegans Hermaphrodites via Secreted Compounds by Maures, Travis J., Booth, Lauren N., Benayoun, Bérénice A., Izrayelit, Yevgeniy, Schroeder, Frank C., Brunet, Anne

“…How an individual's longevity is affected by the opposite sex is still largely unclear. In the nematode Caenorhabditis elegans, the presence of males…”
Get full text

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction by Schaffer, Bethany E., Levin, Rebecca S., Hertz, Nicholas T., Maures, Travis J., Schoof, Michael L., Hollstein, Pablo E., Benayoun, Bérénice A., Banko, Max R., Shaw, Reuben J., Shokat, Kevan M., Brunet, Anne

“…AMP-activated protein kinase (AMPK) is a central energy gauge that regulates metabolism and has been increasingly involved in non-metabolic processes and…”
Get full text

Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis by Kareta, Michael S., Gorges, Laura L., Hafeez, Sana, Benayoun, Bérénice A., Marro, Samuele, Zmoos, Anne-Flore, Cecchini, Matthew J., Spacek, Damek, Batista, Luis F.Z., O’Brien, Megan, Ng, Yi-Han, Ang, Cheen Euong, Vaka, Dedeepya, Artandi, Steven E., Dick, Frederick A., Brunet, Anne, Sage, Julien, Wernig, Marius

“…Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of…”
Get full text

The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan by Valenzano, Dario Riccardo, Benayoun, Bérénice A., Singh, Param Priya, Zhang, Elisa, Etter, Paul D., Hu, Chi-Kuo, Clément-Ziza, Mathieu, Willemsen, David, Cui, Rongfeng, Harel, Itamar, Machado, Ben E., Yee, Muh-Ching, Sharp, Sabrina C., Bustamante, Carlos D., Beyer, Andreas, Johnson, Eric A., Brunet, Anne

“…Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan…”
Get full text

The microbiome: An emerging key player in aging and longevity by Kim, Minhoo, Benayoun, Bérénice A.

“…Revolutionary advancements of high-throughput sequencing and metagenomic tools have provided new insights to microbiome function, including a bidirectional…”
Get full text

Sex-dimorphic expression of extracellular matrix genes in mouse bone marrow neutrophils by McGill, Cassandra J, Ewald, Collin Y, Benayoun, Bérénice A

“…The mammalian innate immune system is sex-dimorphic. Neutrophils are the most abundant leukocyte in humans and represent innate immunity's first line of…”
Get full text

An eQTL-based approach reveals candidate regulators of LINE-1 RNA levels in lymphoblastoid cells by Bravo, Juan I, Mizrahi, Chanelle R, Kim, Seungsoo, Zhang, Lucia, Suh, Yousin, Benayoun, Bérénice A

“…Long interspersed element 1 (LINE-1; L1) are a family of transposons that occupy ~17% of the human genome. Though a small number of L1 copies remain capable of…”
Get full text

A post-translational modification code for transcription factors: sorting through a sea of signals by Benayoun, Bérénice A, Veitia, Reiner A

“…Cellular responses to environmental or physiological cues rely on transduction pathways that must ensure discrimination between different signals. These…”
Get full text

Widespread sex dimorphism in aging and age-related diseases by Sampathkumar, Nirmal K., Bravo, Juan I., Chen, Yilin, Danthi, Prakroothi S., Donahue, Erin K., Lai, Rochelle W., Lu, Ryan, Randall, Lewis T., Vinson, Nika, Benayoun, Bérénice A.

“…Although aging is a conserved phenomenon across evolutionary distant species, aspects of the aging process have been found to differ between males and females…”
Get full text