Search Results - "Benafif, Sarah"

A Review of Prostate Cancer Genome-Wide Association Studies (GWAS) by Benafif, Sarah, Kote-Jarai, Zsofia, Eeles, Rosalind A

“…Prostate cancer is the most common cancer in men in Europe and the United States. The genetic heritability of prostate cancer is contributed to by both rarely…”
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Out-of-hours admissions in patients treated with immune checkpoint inhibitors and their primary management with steroids by Awan, Sidra, Bharucha, Pooja, Steventon, Luke, Simpson, Helen, AHMAD, Tanya, Benafif, Sarah, Shaw, Heather, Chambers, Pinkie

“…Introduction The incidence of immune-related adverse events (irAEs) from immune checkpoint inhibitors (ICI) is well described. However, the impact on emergency…”
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Cancer History and Systemic Anti-Cancer Therapy Independently Predict COVID-19 Mortality: A UK Tertiary Hospital Experience by Sng, Christopher C T, Wong, Yien Ning Sophia, Wu, Anjui, Ottaviani, Diego, Chopra, Neha, Galazi, Myria, Benafif, Sarah, Soosaipillai, Gehan, Roylance, Rebecca, Lee, Alvin J X, Shaw, Heather

“…The COVID-19 pandemic remains a pressing concern to patients with cancer as countries enter the second peak of the pandemic and beyond. It remains unclear…”
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An update on PARP inhibitors for the treatment of cancer by Benafif, Sarah, Hall, Marcia

“…The development of poly (adenosine diphosphate [ADP]) ribose polymerase (PARP) inhibitors (PARPi) has progressed greatly over the last few years and has shown…”
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The BARCODE1 study in primary care: Early results targeting men with increased genetic risk of developing prostate cancer—Examining the interim data from a community-based screening program using polygenic risk score to target screening by McHugh, Jana Kathlyn, ni Raghallaigh, Holly, Bancroft, Elizabeth, Kote-Jarai, Zsofia, Benafif, Sarah, Eeles, Ros A.

“…Abstract only 231 Background: A significant proportion of Prostate cancer (PrCa) risk is attributable to heritable risk factors of which only a minority are…”
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The BARCODE1 pilot study targeting men with increased genetic risk of developing prostate cancer: Examining the feasibility of a community-based screening program using polygenic risk score to target screening by McHugh, Jana Kathlyn, Benafif, Sarah, ni Raghallaigh, Holly, Bancroft, Elizabeth, Kote-Jarai, Zsofia, Eeles, Ros A.

“…Abstract only 227 Background: A significant proportion of Prostate cancer (PrCa) risk is attributable to heritable risk factors of which only a minority are…”
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Efficacy and safety of dendrimer-enhanced (DEP) cabazitaxel (CTX-SPL9111) in advanced esophagogastric cancers in a phase 1/2 trial by Pinato, David James, Jones, Robert Hugh, Forster, Martin D., Joshua, Anthony M., Korolewicz, James, Benafif, Sarah, Aboud, Karam, Liu, Jia (Jenny), Cosman, Rasha, Paull, Jeremy, Fairley, Jacinth, Edmondson, Stephanie Ruth, Spicer, James F.

“…374 Background: There is a significant unmet need in esophagogastric cancers (EGC) due to limited effective treatments (Tx) and poor prognosis. Dendrimers are…”
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Cisplatin and gemcitabine in patients with advanced biliary tract cancer (ABC) and persistent jaundice despite optimal stenting: Effective intervention in patients with luminal disease by Lamarca, Angela, Benafif, Sarah, Ross, Paul, Bridgewater, John, Valle, Juan W

“…Abstract Introduction The advanced biliary tract cancer (ABC)-02 study established cisplatin and gemcitabine (CisGem) as a reference 1st -line regimen for…”
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Precision thoracic oncology in the UK: a two-step NGS pathway for extended molecular profiling in NSCLC by Moore, David, Benafif, Sarah, Bennett, Philip, Argue, Stephanie, Lee, Siow-Ming, Ahmad, Tanya, Papadatos-Pastos, Dionysis, Forster, Martin

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102 Hepatitis B and HIV screening prior to first systemic anticancer therapy (SACT) in an inner-city London thoracic cancer population by Buckley, Thomas, Lucas, Tylan, Odita, Malcolm, Masento, Sebastian, Benafif, Sarah, Forster, Martin, Hiley, Crispin, Jamal-Hanjani, Mariam, Keshwani, Karim, Lee, Siow Ming, Papadatos-Pastos, Dionysis, Swanton, Charlie, Wilson, James, Ahmad, Tanya, Hughes, Daniel Johnathan

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95 Lorlatinib in advanced ALK-rearranged NSCLC – real-world experience in a UK population by Lucas, Tylan, Hassan, Heba, Sattar, Alisha, So, Alfred, Buckley, Thomas, Hunter, Sarah, Masento, Sebastian, Naureen, Sofia, Benafif, Sarah, Boleti, Ekaterina, Tarver, Kathryn, Ahmad, Tanya, Newsom-Davis, Tom, Janusweski, Adam, Shah, Riyaz, Ghosh, Sharmistha, Daniel Johnathan, Hughes

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Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel by Leongamornlert, Daniel A., Saunders, Edward J., Wakerell, Sarah, Whitmore, Ian, Dadaev, Tokhir, Cieza-Borrella, Clara, Benafif, Sarah, Brook, Mark N., Donovan, Jenny L., Hamdy, Freddie C., Neal, David E., Muir, Kenneth, Govindasami, Koveela, Conti, David V., Kote-Jarai, Zsofia, Eeles, Rosalind A.

“…Rare germline mutations in DNA repair genes are associated with prostate cancer (PCa) predisposition and prognosis. To quantify the frequency of germline DNA…”
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Optimising fusion detection through sequential DNA and RNA molecular profiling of non-small cell lung cancer by Moore, David A., Benafif, Sarah, Poskitt, Benjamin, Argue, Stephanie, Lee, Siow-Ming, Ahmad, Tanya, Papadatos-Pastos, Dionysis, Jamal-Hanjani, Mariam, Bennett, Philip, Forster, Martin D.

“…•There are an increasing number of rare but actionable fusions in NSCLC.•Targeting fusion panel testing in those negative by DNA-NGS led to an enriched…”
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Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation by Dillon, Magnus T, Guevara, Jeane, Mohammed, Kabir, Patin, Emmanuel C, Smith, Simon A, Dean, Emma, Jones, Gemma N, Willis, Sophie E, Petrone, Marcella, Silva, Carlos, Thway, Khin, Bunce, Catey, Roxanis, Ioannis, Nenclares, Pablo, Wilkins, Anna, McLaughlin, Martin, Jayme-Laiche, Adoracion, Benafif, Sarah, Nintos, Georgios, Kwatra, Vineet, Grove, Lorna, Mansfield, David, Proszek, Paula, Martin, Philip, Moore, Luiza, Swales, Karen E, Banerji, Udai, Saunders, Mark P, Spicer, James, Forster, Martin D, Harrington, Kevin J

“…BACKGROUNDPhase 1 study of ATRinhibition alone or with radiation therapy (PATRIOT) was a first-in-human phase I study of the oral ATR (ataxia telangiectasia…”
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Clinico-pathological features of MET exon 14 mutation positive NSCLC in the UK by Benafif, Sarah, Greystoke, Alastair, Carter, Mathew, Bulusu, Ramesh, Baijal, Shobhit, Conibear, John, Nintos, Georgios, Papadatos-Pastos, Dionysis, Ahmad, Tanya, Lee, Siow-Ming, Forster, Martin

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The BARCODE1 Pilot: a feasibility study of using germline single nucleotide polymorphisms to target prostate cancer screening by Benafif, Sarah, Ni Raghallaigh, Holly, McGrowder, Eva, Saunders, Edward J., Brook, Mark N., Saya, Sibel, Rageevakumar, Reshma, Wakerell, Sarah, James, Denzil, Chamberlain, Anthony, Taylor, Natalie, Hogben, Matthew, Benton, Barbara, D’Mello, Lucia, Myhill, Kathryn, Mikropoulos, Christos, Bowen‐Perkins, Hywel, Rafi, Imran, Ferris, Michelle, Beattie, Andre, Kuganolipava, Shophia, Sevenoaks, Tamsin, Bower, Juliet, Kumar, Pardeep, Hazell, Steven, deSouza, Nandita M., Antoniou, Antonis, Bancroft, Elizabeth, Kote‐Jarai, Zsofia, Eeles, Rosalind

“…Objectives To assess the feasibility and uptake of a community‐based prostate cancer (PCa) screening programme selecting men according to their genetic risk of…”
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Germline sequencing of advanced prostate cancer patients in the BARCODE2 study by Benafif, Sarah, Whitmore, Ian, Anokian, Ezequiel, Cieza-Borrella, Clara, Saunders, Ed, Kote-Jarai, Zsofia, Eeles, Ros A.

“…Abstract only…”
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Diagnosis and Management of Hereditary Carcinoids by Benafif, Sarah, Eeles, Rosalind

“…Carcinoid tumours arise in cells of the diffuse neuroendocrine system and can develop in a number of anatomical sites including the lungs and the…”
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Presenting Features and Early Mortality from SARS-CoV-2 Infection in Cancer Patients during the Initial Stage of the COVID-19 Pandemic in Europe by Pinato, David J, Lee, Alvin J X, Biello, Federica, Seguí, Elia, Aguilar-Company, Juan, Carbó, Anna, Bruna, Riccardo, Bower, Mark, Rizzo, Gianpiero, Benafif, Sarah, Carmona, Carme, Chopra, Neha, Cruz, Claudia Andrea, D'Avanzo, Francesca, Evans, Joanne S, Galazi, Myria, Garcia-Fructuoso, Isabel, Dalla Pria, Alessia, Newsom-Davis, Thomas, Ottaviani, Diego, Patriarca, Andrea, Reyes, Roxana, Sharkey, Rachel, Sng, Christopher C T, Wong, Yien Ning Sophia, Ferrante, Daniela, Scotti, Lorenza, Avanzi, Gian Carlo, Bellan, Mattia, Castello, Luigi Mario, Marco-Hernández, Javier, Mollà, Meritxell, Pirisi, Mario, Ruiz-Camps, Isabel, Sainaghi, Pier Paolo, Gaidano, Gianluca, Brunet, Joan, Tabernero, Josep, Prat, Aleix, Gennari, Alessandra

“…We describe the outcomes in cancer patients during the initial outbreak of the COVID-19 in Europe from the retrospective, multi-center observational OnCovid…”
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Entrectinib-Induced Myocarditis and Acute Heart Failure Responding to Steroid Treatment: A Case Report by Majeed, Mehraab N., Venkatesan, Subramanian, Papadatos-Pastos, Dionysis, Ahmad, Tanya, Forster, Martin, Demetriades, Polyvios, Hughes, Daniel Johnathan, Benafif, Sarah, Lee, Siow Ming

“…A 72-year-old man presented to his general practitioner with worsening dyspnea and was diagnosed with having recurrent ROS1-positive stage IIIB NSCLC 8 years…”
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