Frequency and factors associated with proteinuria in COVID-19 patients: a cross-sectional study

Proteinuria is a marker of severity and poor outcome of patients in intensive care unit (ICU). The objective of this study was to determine the frequency of proteinuria and the risk factors associated with proteinuria in Congolese COVID-19 patients. The present cross sectional study of proteinuria s...

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Bibliographic Details
Published in:	The Pan African medical journal Vol. 40; p. 37
Main Authors:	Nlandu, Yannick Mayamba, Sakaji, Theodore-Junior Manyka, Engole, Yannick Mompango, Mboliasa, Pitchouna Marie-France Ingole, Bena, Dauphin Mulumba, Abatha, Jessy Mukamamvula, Nkumu, Jean-Robert Mpoke, Nkodila, Aliocha Natuhoyila, Van Eckout, Karel, Kalifa, Golan, Ahmed, Rodolphe, Bukabau, Justine Busanga
Format:	Journal Article
Language:	English
Published:	Uganda African Field Epidemiology Network 2021 The African Field Epidemiology Network
Subjects:	Adult Age Factors Aged Chronic illnesses Confidentiality Coronaviruses COVID-19 COVID-19 - complications COVID-19 - diagnosis Cross-Sectional Studies Democratic Republic of the Congo Diabetes Diabetes Mellitus - epidemiology Ethics Female Humans Hypertension Hypertension - epidemiology Intensive Care Units Kidney diseases Laboratories Male Middle Aged Mortality Normal distribution Oxidative stress Pandemics Patients Polymerase Chain Reaction Privacy Proteins Proteinuria - epidemiology Proteinuria - etiology Respiratory distress syndrome Retrospective Studies Risk Factors Severe acute respiratory syndrome coronavirus 2 Short Communication Urinalysis Urine Values Democratic Republic of the Congo COVID-19 Black African inflammation oxidative stress Proteinuria
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Summary:	Proteinuria is a marker of severity and poor outcome of patients in intensive care unit (ICU). The objective of this study was to determine the frequency of proteinuria and the risk factors associated with proteinuria in Congolese COVID-19 patients. The present cross sectional study of proteinuria status is a post hoc analysis of data from 80 COVID-19 patients admitted at Kinshasa Medical Center (KMC) from March 10 to July 10 , 2020. The population under study came from all adult inpatients (≥18 years old) with a laboratory diagnosis by polymerase chain reaction (PCR) of COVID-19 were selected and divided into two groups (positive proteinuria and negative proteinuria group). Logistic regression models helped to identify the factors associated with proteinuria. The P value significance level was 0.05. Among 80 patients who tested positive for SARS-CoV-2 RT-PCR, 55% had proteinuria. The mean age was 55.2 ± 12.8 years. Fourty-seven patients (58.8%) had history of hypertension and 26 patients (32.5%) diabetes. Multivariable analysis showed age ≥ 65 years (aOR 5,04; 95% CI: 1.51-16.78), diabetes (aOR 3,15; 95% CI: 1.14-8.72), ASAT >40 UI/L (aOR 7,08; 95% CI: 2.40-20.87), ferritin >300 (aOR 13,47; 95% CI: 1.56-26.25) as factors independently associated with proteinuria in COVID-19 patients. Proteinuria is common in Congolese COVID-19 patients and is associated with age, diabetes, ferritin and aspartate aminotransferase (ASAT).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1937-8688 1937-8688
DOI:	10.11604/pamj.2021.40.37.29796