Intravenous Transplantation of Human Umbilical Cord Blood Mononuclear Cells Overexpressing Nerve Growth Factor Improves Spatial Memory in APP/PS1 Transgenic Mice with a Model of Alzheimer’s Disease

Intravenous Transplantation of Human Umbilical Cord Blood Mononuclear Cells Overexpressing Nerve Growth Factor Improves Spatial Memory in APP/PS1 Transgenic Mice with a Model of Alzheimer’s Disease

Alzheimer’s disease is a progressive incurable neurodegenerative disease manifested by dementia and other cognitive disorders. Gene-cell therapy is one of the most promising trends in the development of treatment for Alzheimer’s disease. The study was aimed to evaluate the therapeutic potential of i...

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Bibliographic Details
Published in:BioNanoScience Vol. 8; no. 1; pp. 473 - 480
Main Authors: Mukhamedyarov, M. A., Leushina, A. V., Tikhonova, A. E., Petukhova, E. O., Garanina, E. E., Ben Taleb, R., Kaligin, M. S., Mukhamedshina, Y. O., Rizvanov, A. A., Zefirov, A. L., Islamov, R. R.
Format: Journal Article
Language:English
Published: New York Springer US 01-03-2018
Springer Nature B.V
Subjects:
Anxiety
Biological and Medical Physics
Biomaterials
Biophysics
Circuits and Systems
Cognitive ability
Computer memory
Cord blood
Dementia disorders
Engineering
Expression vectors
Growth factors
Intravenous administration
Leukocytes (mononuclear)
Memory tasks
Mice
Nanotechnology
Nerve growth factor
Presenilin 1
Rodents
Spatial analysis
Spatial memory
Therapy
Transgenic animals
Transgenic mice
Transplantation
Umbilical cord
Nerve growth factor
Umbilical cord blood mononuclear cells
APP/PS1 transgenic mice
Alzheimer’s disease
Gene-cell therapy
Stem cells
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Summary:Alzheimer’s disease is a progressive incurable neurodegenerative disease manifested by dementia and other cognitive disorders. Gene-cell therapy is one of the most promising trends in the development of treatment for Alzheimer’s disease. The study was aimed to evaluate the therapeutic potential of intravenous transplantation of human umbilical cord blood mononuclear cells (UCBMCs) transduced with adenoviral vectors overexpressing nerve growth factor (NGF) for the treatment of Alzheimer’s disease in an APP/PS1 transgenic mice model. The transplantation of NGF-expressing UCBMCs was found to improve spatial memory and decrease anxiety in APP/PS1 mice. Grafted cells and their expression of NGF were detected in the cortex and hippocampus of transgenic mice in the period up to 90 days after transplantation. Thus, gene-cell therapy based on the use of NGF-overexpressing UCBMCs is a promising approach for the development of Alzheimer’s disease treatments.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-017-0497-9