Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in mice

Neonatal Fc receptors for immunoglobulin (Ig)G (FcRn) assume a central role in regulating host IgG levels and IgG transport across polarized epithelial barriers. We have attempted to elucidate the contribution of FcRn in controlling Helicobacter infection in the stomach. C57BL/6J wild-type or FcRn −...

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Published in:	Mucosal immunology Vol. 5; no. 1; pp. 87 - 98
Main Authors:	Ben Suleiman, Y, Yoshida, M, Nishiumi, S, Tanaka, H, Mimura, T, Nobutani, K, Yamamoto, K, Takenaka, M, Aoganghua, A, Miki, I, Ota, H, Takahashi, S, Matsui, H, Nakamura, M, Blumberg, R S, Azuma, T
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-01-2012 Elsevier Limited
Subjects:	Allergology Animals Antibodies Antibodies, Bacterial - immunology Antibodies, Bacterial - metabolism Biomedical and Life Sciences Biomedicine Gastroenterology Helicobacter heilmannii - immunology Helicobacter heilmannii - pathogenicity Helicobacter Infections - immunology Helicobacter pylori - immunology Helicobacter pylori - pathogenicity Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunology Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Mice Mice, Inbred C57BL Mice, Knockout Receptors, Fc - genetics Receptors, Fc - immunology Receptors, Fc - metabolism Stomach - pathology Transcytosis Virulence
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Summary:	Neonatal Fc receptors for immunoglobulin (Ig)G (FcRn) assume a central role in regulating host IgG levels and IgG transport across polarized epithelial barriers. We have attempted to elucidate the contribution of FcRn in controlling Helicobacter infection in the stomach. C57BL/6J wild-type or FcRn −/− mice were infected with Helicobacter heilmannii , and gastric lesions, bacterial load and the levels of antigen-specific IgG in serum and gastric juice were analyzed. The elevated levels of anti- H. heimannii IgG in gastric juice were observed exclusively in wild-type mice but not in FcRn −/− mice. In contrast, an increase in lymphoid follicles and bacterial loads along with deeper gastric epithelium invasion were noted in FcRn −/− mice. C57BL/6J wild-type or FcRn −/− mice were also infected with Helicobacter pylori SS1, and the results of the bacterial load in stomachs of these mice and the anti- H. pylori IgG levels in serum and gastric juice were similar to those from H. heilmannii infection. Our data suggest that FcRn can be functionally expressed in the stomach, which is involved in transcytosis of IgG, and prevent colonization by H. heilmannii and the associated pathological consequences of infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1933-0219 1935-3456
DOI:	10.1038/mi.2011.53