Search Results - "Ben Moshe, Tehila"

BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression by Mandel, Ilana, Haves Ziv, Dana, Goldshtein, Ilana, Peretz, Tsuri, Alishekevitz, Dror, Fridman Dror, Anna, Hakim, Motti, Hashmueli, Sharon, Friedman, Itay, Sapir, Yair, Greco, Rita, Qu, Hongjing, Nestle, Frank, Wiederschain, Dmitri, Pao, Lily, Sharma, Sharad, Ben Moshe, Tehila

“…BackgroundCancer immunotherapy has revolutionized cancer treatment. However, considering the limited success of immunotherapy to only some cancer types and…”
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Survival Function of the FADD-CASPASE-8-cFLIPL Complex by Dillon, Christopher P., Oberst, Andrew, Weinlich, Ricardo, Janke, Laura J., Kang, Tae-Bong, Ben-Moshe, Tehila, Mak, Tak W., Wallach, David, Green, Douglas R.

“…Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter molecule, FADD, required for caspase-8 activation, and cFLIPL, a…”
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Role of Thiopurines in Pediatric Inflammatory Bowel Diseases: A Real-Life Prospective Cohort Study by Atia, Ohad, Ledder, Oren, Ben-Moshe, Tehila, Lev-Tzion, Raffi, Rachmen, Yelana, Meyer, Esther O., Beeri, Rachel, Renbaum, Pinhas, Shamasneh, Ibrahim, Shteyer, Eyal, Turner, Dan

“…OBJECTIVES:Use of thiopurines for inflammatory bowel diseases (IBDs) is declining in some parts of the world. We aimed to explore outcomes of thiopurines and…”
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The Effect of Nutritional Therapy on Bone Mineral Density and Bone Metabolism in Pediatric Crohn Disease by Lev‐Tzion, Raffi, Ben‐Moshe, Tehila, Abitbol, Guila, Ledder, Oren, Peleg, Sarit, Millman, Peri, Shaoul, Ron, Kori, Michal, Assa, Amit, Cohen, Shlomi, Strich, David, Revel‐Vilk, Shoshana, Tiomkin, Maayan, Levine, Arie, Sigall Boneh, Rotem, Turner, Dan

“…ABSTRACT Objectives: Both the inflammatory burden of Crohn disease (CD) and corticosteroids have a negative effect on bone density. Exclusive enteral nutrition…”
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Role of Thiopurines in Pediatric Inflammatory Bowel Diseases by Atia, Ohad, Ledder, Oren, Ben‐Moshe, Tehila, Lev‐Tzion, Raffi, Rachmen, Yelana, Meyer, Esther O., Beeri, Rachel, Renbaum, Pinhas, Shamasneh, Ibrahim, Shteyer, Eyal, Turner, Dan

“…ABSTRACT Objectives: Use of thiopurines for inflammatory bowel diseases (IBDs) is declining in some parts of the world. We aimed to explore outcomes of…”
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Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks by Barash, Hila, Gross, Eitan R, Edrei, Yifat, Ella, Ezra, Israel, Ariel, Cohen, Irit, Corchia, Nathalie, Ben-Moshe, Tehila, Pappo, Orit, Pikarsky, Eli, Goldenberg, Daniel, Shiloh, Yosef, Galun, Eithan, Abramovitch, Rinat

“…Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and is considered to be the outcome of chronic liver inflammation…”
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Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles by Kang, Tae-Bong, Ben-Moshe, Tehila, Varfolomeev, Eugene E, Pewzner-Jung, Yael, Yogev, Nir, Jurewicz, Anna, Waisman, Ari, Brenner, Ori, Haffner, Rebecca, Gustafsson, Erika, Ramakrishnan, Parameswaran, Lapidot, Tsvee, Wallach, David

“…Knockout of caspase-8, a cysteine protease that participates in the signaling for cell death by receptors of the TNF/nerve growth factor family, is lethal to…”
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Novel Anti-Melanoma Immunotherapies : Disarming Tumor Escape Mechanisms by Hammer, Ohad, Sivan, Sapoznik, Ortenberg, Rona, Besser, Michal J., Ben-Moshe, Tehila, Jacob, Schachter, Markel, Gal

“…The immune system fights cancer and sometimes temporarily eliminates it or reaches an equilibrium stage of tumor growth. However, continuous immunological…”
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Survival function of the FADD-CASPASE-8-cFLIP(L) complex by Dillon, Christopher P, Oberst, Andrew, Weinlich, Ricardo, Janke, Laura J, Kang, Tae-Bong, Ben-Moshe, Tehila, Mak, Tak W, Wallach, David, Green, Douglas R

“…Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter molecule, FADD, required for caspase-8 activation, and cFLIPL, a…”
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Abstract 3266: BND-22, a first-in-class, anti-ILT2 monoclonal antibody inhibits the immunosuppressive effects of HLA-G and enhances anti-tumor activity of immune cells in preclinical in vitro, ex vivo, and in vivo models by Mandel, Ilana, Haves, Dana, Goldshtein, Ilana, Peretz, Tsuri, Alishekevitz, Dror, Sapir, Yair, Hashmueli, Sharon, Friedman, Itay, Moshe, Tehila Ben

“…Abstract Background: Ig-like transcripts (ILTs) are a family of immuno-modulating receptors expressed on immune cells. ILT2 is an inhibitory receptor expressed…”
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Role of Thiopurines in Pediatric Inflammatory Bowel Diseases: A Real-Life Prospective Cohort Study by Atia, Ohad, Ledder, Oren, Ben-Moshe, Tehila, Lev-Tzion, Raffi, Rachmen, Yelana, Meyer, Esther O, Beeri, Rachel, Renbaum, Pinhas, Shamasneh, Ibrahim, Shteyer, Eyal, Turner, Dan

“…Use of thiopurines for inflammatory bowel diseases (IBDs) is declining in some parts of the world. We aimed to explore outcomes of thiopurines and predictors…”
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Evaluation of pharmacodynamic and patient enrichment biomarkers for SAR444881, a first-in-class anti-ILT2 monoclonal antibody for cancer immunotherapy by Mandel, Ilana, Wang, Rui, Caron, Anne, Marquez, Eladio, Dib, Colette, Jackson, Donald, Deantonio, Cecilia, Haves, Dana, Goldshtein, Ilana, Peretz, Tsuri, Alishekevitz, Dror, Hashmueli, Sharon, Sapir, Yair, Ben Moshe, Tehila, Abbadessa, Giovanni, Friedman, Itay, Crawford, Nigel

“…2571 Background: Leukocyte Ig-like receptor B1 [LILRB1; ILT2] is an inhibitory receptor expressed on various immune cells. ILT2 binds to classical and…”
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Abstract 2846A: CD28 shedding is a novel immune-regulatory mechanism found in cancer patients which directly inhibits anti PD-1 effect by Hakim, Motti, Dror, Anna Fridman, Alishekevitz, Dror, Meilin, Edna, Shilovizky, Orit, Weber, Jeffrey S., Sapir, Yair, Shulman, Avidor, Moshe, Tehila Ben

“…Abstract Background The interaction between the CD28 receptor and its B7 ligands has a crucial role in the induction of a potent and persistent anti-tumor T…”
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Abstract 3920: BND-35, a novel anti-ILT3 antibody for remodulation of the tumor microenvironment by Peretz, Tsuri, Pizem, Yoav, Iancovici, Liat, Peled, Ella, Hakim, Motti, Hashmueli, Sharon, Mandel, Ilana, Sapir, Yair, Moshe, Tehila Ben

“…Abstract Background: ILT3 (LILRB4) is expressed in various suppressive myeloid cells including tumor associated macrophages (TAM), myeloid derived suppressor…”
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The Effect of Nutritional Therapy on Bone Mineral Density and Bone Metabolism in Pediatric Crohn's Disease by Lev-Tzion, Raffi, Ben-Moshe, Tehila, Abitbol, Guila, Ledder, Oren, Peleg, Sarit, Millman, Peri, Shaoul, Ron, Kori, Michal, Assa, Amit, Cohen, Shlomi, Strich, David, Revel-Vilk, Shoshana, Tiomkin, Maayan, Levine, Arie, Boneh, Rotem Sigall, Turner, Dan

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Novel immunotherapy for malignant melanoma with a monoclonal antibody that blocks CEACAM1 homophilic interactions by Ortenberg, Rona, Sapir, Yair, Raz, Lee, Hershkovitz, Liat, Ben Arav, Ayelet, Sapoznik, Sivan, Barshack, Iris, Avivi, Camila, Berkun, Yackov, Besser, Michal J, Ben-Moshe, Tehila, Schachter, Jacob, Markel, Gal

“…CEACAM1 (biliary glycoprotein-1, CD66a) was reported as a strong clinical predictor of poor prognosis in melanoma. We have previously identified CEACAM1 as a…”
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Abstract 262: Inhibition of the novel immune checkpoint CEACAM1 enhances antitumor immunological activity by Markel, Gal, Mandel, Ilana, Sapir, Yair, Hakim, Motti, Hashmueli, Sharon, Ben-Moshe, Tehila

“…Abstract Blockade of co-inhibitory immune receptors has become a promising approach for the activation of anti-tumor immunity. CEACAM1, a recently…”
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Abstract 654: CD28 shedding is a novel resistance mechanism to anti PD-1 therapy by Hakim, Motti, Dror, Anna Fridman, Gabay, Tal Shahar, Alishekevitz, Dror, Meilin, Edna, Mandel, Ilana, Sapir, Yair, Shulman, Avidor, Moshe, Tehila Ben

“…Abstract Background: Resistance mechanisms to anti-PD1 therapy remain poorly understood. Studies have implicated that efficient anti-PD1 therapy relies…”
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Inhibition of the novel immune checkpoint CEACAM1 to enhance anti-tumor immunological activity by Markel, Gal, Sapir, Yair, Mandel, Ilana, Hakim, Motti, Shaked, Rony, Meilin, Edna, McClanahan, Terri, Loboda, Andrey, Hashmueli, Sharon, Ben Moshe, Tehila

“…Abstract only…”
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Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R by Atsmon, Jacob, Brill-Almon, Einat, Nadri-Shay, Carmit, Chertkoff, Raul, Alon, Sari, Shaikevich, Dimitri, Volokhov, Inna, Haim, Kirsten Y., Bartfeld, Daniel, Shulman, Avidor, Ruderfer, Ilya, Ben-Moshe, Tehila, Shilovitzky, Orit, Soreq, Hermona, Shaaltiel, Yoseph

“…PRX-105 is a plant-derived recombinant version of the human ‘read-through’ acetylcholinesterase splice variant (AChE-R). Its active site structure is similar…”
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