Search Results - "Ben B. Whitlock"

Oxidants Inhibit ERK/MAPK and Prevent Its Ability to Delay Neutrophil Apoptosis Downstream of Mitochondrial Changes and at the Level of XIAP by Gardai, Shyra J, Whitlock, Ben B, Xiao, Yi Qun, Bratton, Donna B, Henson, Peter M

“…Normal spontaneous apoptosis in neutrophils is enhanced by “stress” stimuli such as tumor necrosis factor-α, Fas ligand, and oxidants, and this effect is…”
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Activation of SHIP by NADPH Oxidase-stimulated Lyn Leads to Enhanced Apoptosis in Neutrophils by Gardai, Shyra, Whitlock, Ben B, Helgason, Cheryl, Ambruso, Dan, Fadok, Valerie, Bratton, Donna, Henson, Peter M

“…Neutrophils undergo rapid spontaneous apoptosis. Multiple antiapoptotic stimuli can inhibit this process via activation of the Akt pathway. However, despite no…”
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×Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils by Gardai, Shyra J, Hildeman, David A, Frankel, Steve K, Whitlock, Ben B, Frasch, S Courtney, Borregaard, Niels, Marrack, Philippa, Bratton, Donna L, Henson, Peter M

“…Although important for apoptosis, the mechanism of Bax regulation is poorly understood. This study demonstrates that phosphorylation of Ser 184 regulates Bax…”
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Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis by Avdi, N J, Nick, J A, Whitlock, B B, Billstrom, M A, Henson, P M, Johnson, G L, Worthen, G S

“…The intensity and duration of an inflammatory response depends on the balance of factors that favor perpetuation versus resolution. At sites of inflammation,…”
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Tumor Necrosis Factor-α Activation of the c-Jun N-terminal Kinase Pathway in Human Neutrophils by Avdi, Natalie J., Nick, Jerry A., Whitlock, Ben B., Billstrom, Marcella A., Henson, Peter M., Johnson, Gary L., Worthen, G. Scott

“…The intensity and duration of an inflammatory response depends on the balance of factors that favor perpetuation versus resolution. At sites of inflammation,…”
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Differential roles for alphaMbeta2 integrin clustering or activation in the control of apoptosis via regulation of Akt and ERK survival mechanisms by Whitlock, Ben B, Gardai, Shyra, Fadok, Valerie, Bratton, Donna, Henson, Peter M

“…The role of integrins in leukocyte apoptosis is unclear, some studies suggest enhancement, others inhibition. We have found that (beta)2-integrin engagement on…”
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Differential Roles for αMβ2Integrin Clustering or Activation in the Control of Apoptosis via Regulation of Akt and ERK Survival Mechanisms by Whitlock, Ben B., Gardai, Shyra, Fadok, Valerie, Bratton, Donna, Henson, Peter M.

“…The role of integrins in leukocyte apoptosis is unclear, some studies suggest enhancement, others inhibition. We have found that β2-integrin engagement on…”
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Tumor Necrosis Factor-α Activation of the c-Jun N-terminal Kinase Pathway in Human Neutrophils by Natalie J. Avdi, Jerry A. Nick, Ben B. Whitlock, Marcella A. Billstrom, Peter M. Henson, Gary L. Johnson, G. Scott Worthen

“…The intensity and duration of an inflammatory response depends on the balance of factors that favor perpetuation versus resolution. At sites of inflammation,…”
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Differential localization of three distinct binding sites for sigma receptor ligands in rat spleen by Wolfe, Seth A., Ha, Byeong Keun, Whitlock, Ben B., Saini, Priya

“…In vitro receptor autoradiography was used to localize σ 1 receptors, σ 2 receptors, and novel haloperidol/DTG-inaccessible sites for sigma and opiate ligands…”
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Sigma-1 receptors modulate functional activity of rat splenocytes by Liu, Yuhong, Whitlock, Ben B., Pultz, Joseph A., Wolfe, Seth A.

“…Neuroleptics, opiates, and cocaine are commonly prescribed for or abused by humans. Although primarily used for their actions at other receptors in brain,…”
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Initial characterization and autoradiographic localization of a novel sigma/opioid binding site in immune tissues by Whitlock, Ben B., Liu, Yuhong, Chang, Susie, Saini, Priya, Ha, Byeong Keun, Barrett, thomas W., Wolfe, Seth A.

“…High concentrations of novel, haloperidol-and DTG-inaccessible ( + )-[ 3 H]-3-PPP binding sites were found in human peripheral blood leukocytes, rat spleen and…”
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