A cross sectional study of bone and cartilage biomarkers: correlation with structural damage in rheumatoid arthritis

The aim of our study was to assess the relationship between bone and cartilage remodeling biomarkers and joint damage in Rheumatoid Arthritis (RA), and to detect whether they have the capacity to predict the progression of joint disease assessment by computed tomography (CT) erosion score. We analyz...

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Bibliographic Details
Published in:	Libyan journal of medicine Vol. 13; no. 1; pp. 1512330 - 7
Main Authors:	Ben Achour, Wael, Bouaziz, Mouna, Mechri, Meriem, Zouari, Béchir, Bahlous, Afef, Abdelmoula, Leila, Laadhar, Lilia, Sellami, Maryam, Sahli, Hela, Cheour, Elhem
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01-01-2018 Taylor & Francis Ltd Taylor & Francis Group
Subjects:	Adult Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - diagnostic imaging Biomarkers Biomarkers - blood Bone Resorption - blood Bone Resorption - diagnostic imaging Bone Resorption - etiology Cartilage - diagnostic imaging Cartilage - metabolism Cartilage Oligomeric Matrix Protein - blood Collagen Collagen - blood Collagen Type I - blood Collagen Type II - blood Cross-Sectional Studies Disease Progression Family medical history Female Health risk assessment Humans Medical imaging Metabolism Metacarpophalangeal Joint - diagnostic imaging Middle Aged NMR Nuclear magnetic resonance Original Osteocalcin - blood Peptide Fragments - blood Peptides - blood Phosphopeptides - blood Procollagen - blood Proteins RA, biomarkers, CT Rheumatoid arthritis Rheumatology Single-Blind Method Tomography, X-Ray Computed - statistics & numerical data Wrist Wrist - diagnostic imaging RA, biomarkers, CT
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Summary:	The aim of our study was to assess the relationship between bone and cartilage remodeling biomarkers and joint damage in Rheumatoid Arthritis (RA), and to detect whether they have the capacity to predict the progression of joint disease assessment by computed tomography (CT) erosion score. We analyzed 65 female patients with established RA in our Rheumatology Department. Serum levels of bone and cartilage markers were measured: osteocalcin (OC), N-propeptide of type I collagen (PINP), collagen type I and II, C-telopeptide (CTX I, CTX-II) and cartilage oligomeric matrix protein (COMP). Radiography of both wrist and MCP joints were available. Two expert-readers independently scored articular damage and progression using the High-resolution low dose CT scan in a blinded fashion. 65 female patients with established RA with a median age of 44 years were included. The median disease-duration was two years and the median (Disease activity score) DAS 28 score at 4.46 [2.65-7.36]. The percentage of patient with low disease activity was 13.8%, while 55.4 and 30.8% for those with moderate and high disease activity respectively. The resorption bone markers were high in active versus non-active RA. Wrist and MCP erosion scores were also associated with RA activity. Our study shows that biomarkers of bone and cartilage collagen breakdown were related to specific joint erosion in RA and could predict subsequent radiographic damage in RA. Further larger scale longitudinal studies maybe needed to confirm our data.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1993-2820 1819-6357
DOI:	10.1080/19932820.2018.1512330