Prognostic impact of karyotype in de novo acute myeloid leukemia: study of 139 cases

A group of 139 patients with de novo acute myeloid leukemia were investigated to determine the prognostic significance of karyotype on early death, complete remission, continuous complete remission and survival. There were 27 children and 112 adults. Mean age was 32 years. t(15;17) was found associa...

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Bibliographic Details
Published in:	Tunisie Medicale Vol. 80; no. 9; p. 531
Main Authors:	Sennana Sendi, Halima, Elghezal, Hatem, Temmi, Henda, Gribaa, Moez, Laatiri, Adnène, Ben Abid, Héla, Ben Abdeladhime, Abdeladhime, Elloumi, Moez, Hafsia, Aicha, Saad, Ali
Format:	Journal Article
Language:	French
Published:	Tunisia 01-09-2002
Subjects:	Acute Disease Adolescent Adult Child Chromosome Aberrations Female Humans Karyotyping Leukemia, Myeloid - genetics Leukemia, Myeloid - pathology Male Middle Aged Prognosis Retrospective Studies Survival
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Summary:	A group of 139 patients with de novo acute myeloid leukemia were investigated to determine the prognostic significance of karyotype on early death, complete remission, continuous complete remission and survival. There were 27 children and 112 adults. Mean age was 32 years. t(15;17) was found associated with a high rate of early death and a diploid karyotype with long continuous complete remission. The presence of a structural change was predictive of shorter survivals. The study of the prognostic impact of recurrent anomalies reveals a good prognostic impact for normal karyotype (1 year survival probability: 40%), followed by t(8;21) (1 year survival probability: 24%), and by t(15;17) (1 year survival probability: 9%).
ISSN:	0041-4131