Search Results - "Ben‐Nun, Yael"

mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity by Meena, Naresh Kumar, Pattanayak, Shakti Prasad, Ben‐Nun, Yael, Benhamron, Sandrine, Kumar, Saran, Merquiol, Emmanuelle, Hövelmeyer, Nadine, Blum, Galia, Tirosh, Boaz

“…Summary Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell metabolism and lymphocyte proliferation. It is inhibited by the tuberous…”
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Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3 by Alishekevitz, Dror, Gingis-Velitski, Svetlana, Kaidar-Person, Orit, Gutter-Kapon, Lilach, Scherer, Sandra D., Raviv, Ziv, Merquiol, Emmanuelle, Ben-Nun, Yael, Miller, Valeria, Rachman-Tzemah, Chen, Timaner, Michael, Mumblat, Yelena, Ilan, Neta, Loven, David, Hershkovitz, Dov, Satchi-Fainaro, Ronit, Blum, Galia, Sleeman, Jonathan P., Vlodavsky, Israel, Shaked, Yuval

“…While chemotherapy strongly restricts or reverses tumor growth, the response of host tissue to therapy can counteract its anti-tumor activity by promoting…”
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Characterizing Cathepsin Activity and Macrophage Subtypes in Excised Human Carotid Plaques by Abd-Elrahman, Ihab, Meir, Karen, Kosuge, Hisanori, Ben-Nun, Yael, Weiss Sadan, Tommy, Rubinstein, Chen, Samet, Yaacov, McConnell, Michael V, Blum, Galia

“…BACKGROUND AND PURPOSE—Atherosclerosis is a leading cause of mortality worldwide, contributing to both strokes and heart attacks. Macrophages are key players…”
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Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction by Adhikary, Utsarga, Paulo, Joao A., Godes, Marina, Roychoudhury, Shrabasti, Prew, Michelle S., Ben-Nun, Yael, Yu, Ellen W., Budhraja, Amit, Opferman, Joseph T., Chowdhury, Dipanjan, Gygi, Steven P., Walensky, Loren D.

“…MCL-1 is a high-priority target due to its dominant role in the pathogenesis and chemoresistance of cancer, yet clinical trials of MCL-1 inhibitors are…”
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Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion by Abd-Elrahman, Ihab, Kosuge, Hisanori, Wises Sadan, Tommy, Ben-Nun, Yael, Meir, Karen, Rubinstein, Chen, Bogyo, Matthew, McConnell, Michael V, Blum, Galia

“…Cardiovascular disease is the leading cause of death worldwide, mainly due to an increasing prevalence of atherosclerosis characterized by inflammatory…”
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Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam Cells by Weiss-Sadan, Tommy, Maimoun, David, Oelschlagel, Diana, Kaschani, Farnusch, Misiak, Danny, Gaikwad, Hanmant, Ben-Nun, Yael, Merquiol, Emmanuelle, Anaki, Adi, Tsvirkun, Darya, Kaiser, Markus, Michl, Patrick, Gotsman, Israel, Blum, Galia

“…BACKGROUND/AIMSAtherosclerosis underlies the majority of cardiovascular events, consequent to non-resolving inflammation. Considerable evidence implicates…”
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Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins by Rothberg, Jennifer M, Bailey, Kate M, Wojtkowiak, Jonathan W, Ben-Nun, Yael, Bogyo, Matthew, Weber, Ekkehard, Moin, Kamiar, Blum, Galia, Mattingly, Raymond R, Gillies, Robert J, Sloane, Bonnie F

“…One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that…”
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Molecular Imaging of Cancer Using X‑ray Computed Tomography with Protease Targeted Iodinated Activity-Based Probes by Gaikwad, Hanmant K, Tsvirkun, Darya, Ben-Nun, Yael, Merquiol, Emmanuelle, Popovtzer, Rachela, Blum, Galia

“…X-ray computed tomography (CT) is a robust, precise, fast, and reliable imaging method that enables excellent spatial resolution and quantification of contrast…”
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Cathepsin nanofiber substrates as potential agents for targeted drug delivery by Ben-Nun, Yael, Fichman, Galit, Adler-Abramovich, Lihi, Turk, Boris, Gazit, Ehud, Blum, Galia

“…The development of reactive drug carriers that could actively respond to biological signals is a challenging task. Different peptides can self-assemble into…”
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CT Imaging of Enzymatic Activity in Cancer Using Covalent Probes Reveal a Size-Dependent Pattern by Tsvirkun, Darya, Ben-Nun, Yael, Merquiol, Emmanuelle, Zlotver, Ivan, Meir, Karen, Weiss-Sadan, Tommy, Matok, Ilan, Popovtzer, Rachela, Blum, Galia

“…X-ray CT instruments are among the most available, efficient, and cost-effective imaging modalities in hospitals. The field of CT molecular imaging is emerging…”
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Le cabinet de curiosités de Jan et Eva Švankmajer by Nun, Yaël Ben, Ruivo, Céline

“…La réalisation de films d’animation donne lieu à la création d’une quantité considérable de documents et d’objets de production : dessins de concepts,…”
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A Theranostic Cathepsin Activity-Based Probe for Noninvasive Intervention in Cardiovascular Diseases by Weiss-Sadan, Tommy, Ben-Nun, Yael, Maimoun, David, Merquiol, Emmanuelle, Abd-Elrahman, Ihab, Gotsman, Israel, Blum, Galia

“…Despite the common use of lipid-lowering medications, cardiovascular diseases continue to be a significant health concern. Atherosclerosis, one of the most…”
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Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy by Ben-Nun, Yael, Merquiol, Emmanuelle, Brandis, Alexander, Turk, Boris, Scherz, Avigdor, Blum, Galia

“…Elevated cathepsins levels and activities are found in several types of human cancer, making them valuable biomarkers for detection and targeting therapeutics…”
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Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation[S] by Weiss-Sadan, Tommy, Itzhak, Gal, Kaschani, Farnusch, Yu, Zhanru, Mahameed, Mohamed, Anaki, Adi, Ben-Nun, Yael, Merquiol, Emmanuelle, Tirosh, Boaz, Kessler, Benedikt, Kaiser, Markus, Blum, Galia

“…Remodeling of cellular metabolism is a genuine feature of rapidly growing cells. Herein we report that mouse embryonic fibroblasts, lacking the Cathepsin L…”
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Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization by Hauseman, Zachary J., Harvey, Edward P., Newman, Catherine E., Wales, Thomas E., Bucci, Joel C., Mintseris, Julian, Schweppe, Devin K., David, Liron, Fan, Lixin, Cohen, Daniel T., Herce, Henry D., Mourtada, Rida, Ben-Nun, Yael, Bloch, Noah B., Hansen, Scott B., Wu, Hao, Gygi, Steven P., Engen, John R., Walensky, Loren D.

“…BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX…”
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Detecting cathepsin activity in human osteoarthritis via activity-based probes by Ben-Aderet, Louisa, Merquiol, Emmanuelle, Fahham, Duha, Kumar, Ashok, Reich, Eli, Ben-Nun, Yael, Kandel, Leonid, Haze, Amir, Liebergall, Meir, Kosińska, Marta K, Steinmeyer, Juergen, Turk, Boris, Blum, Galia, Dvir-Ginzberg, Mona

“…Lysosomal cathepsins have been reported to contribute to Osteoarthritis (OA) pathophysiology due to their increase in pro-inflammatory conditions. Given the…”
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Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins by Blau, Rachel, Epshtein, Yana, Pisarevsky, Evgeni, Tiram, Galia, Israeli Dangoor, Sahar, Yeini, Eilam, Krivitsky, Adva, Eldar-Boock, Anat, Ben-Shushan, Dikla, Gibori, Hadas, Scomparin, Anna, Green, Ori, Ben-Nun, Yael, Merquiol, Emmanuelle, Doron, Hila, Blum, Galia, Erez, Neta, Grossman, Rachel, Ram, Zvi, Shabat, Doron, Satchi-Fainaro, Ronit

“…Complete tumor removal during surgery has a great impact on patient survival. To that end, the surgeon should detect the tumor, remove it and validate that…”
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Identification of a Structural Determinant for Selective Targeting of HDMX by Ben-Nun, Yael, Seo, Hyuk-Soo, Harvey, Edward P., Hauseman, Zachary J., Wales, Thomas E., Newman, Catherine E., Cathcart, Ann M., Engen, John R., Dhe-Paganon, Sirano, Walensky, Loren D.

“…p53 is a critical tumor-suppressor protein that guards the human genome against mutations by inducing cell-cycle arrest or apoptosis. Cancer cells subvert p53…”
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Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation by Weiss-Sadan, Tommy, Itzhak, Gal, Kaschani, Farnusch, Yu, Zhanru, Mahameed, Mohamed, Anaki, Adi, Ben-Nun, Yael, Merquiol, Emmanuelle, Tirosh, Boaz, Kessler, Benedikt, Kaiser, Markus, Blum, Galia

“…Rapidly proliferating cells reshape their metabolism to satisfy their ever-lasting need for cellular building blocks. This phenomenon is exemplified in certain…”
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Acid-Mediated Tumor Proteolysis: Contribution of Cysteine Cathepsins12 by Rothberg, Jennifer M, Bailey, Kate M, Wojtkowiak, Jonathan W, Ben-Nun, Yael, Bogyo, Matthew, Weber, Ekkehard, Moin, Kamiar, Blum, Galia, Mattingly, Raymond R, Gillies, Robert J, Sloane, Bonnie F

“…One of the noncellular microenvironmental factors that contribute to malignancy of solid tumors is acidic peritumoral pH. We have previously demonstrated that…”
Get full text