Search Results - "Benítez Iglesias, Raúl"
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The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts
Published in The Journal of biological chemistry (31-08-2018)“…Sarcoplasmic reticulum (SR) Ca2+ cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca2+-ATPase (SERCA2a). Abnormal SR Ca2+ cycling is thought…”
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2
Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes
Published in Cardiovascular research (01-04-2015)“…Ageing-related cardiac disorders such as heart failure and atrial fibrillation often present with intracellular calcium homeostasis dysfunction. However,…”
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3
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis
Published in Cardiovascular research (01-03-2019)“…Abstract Aims Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the…”
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4
Data-based fault detection in chemical processes: Managing records with operator intervention and uncertain labels
Published in Expert systems with applications (30-11-2016)“…•A fault detection system under uncertain labels and dynamic attributes is proposed.•A systematic framework for improving operator-process interaction is…”
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Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations
Published in Proceedings of the National Academy of Sciences - PNAS (15-11-2016)“…Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disease caused by defective prelamin A processing, leading to nuclear lamina alterations, severe…”
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6
Phospholamban Knockout Breaks Arrhythmogenic Ca2+ Waves and Suppresses Catecholaminergic Polymorphic Ventricular Tachycardia in Mice
Published in Circulation research (16-08-2013)“…RATIONALE:Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca ATPase. PLN knockout (PLN-KO) enhances sarcoplasmic reticulum Ca load…”
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7
Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes
Published in The Journal of biological chemistry (14-08-2015)“…The cardiac Ca2+ release channel (ryanodine receptor, RyR2) plays an essential role in excitation-contraction coupling in cardiac muscle cells. Effective and…”
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8
Prevention of adenosine A2A receptor activation diminishes beat-to-beat alternation in human atrial myocytes
Published in Basic research in cardiology (2016)“…Atrial fibrillation (AF) has been associated with increased spontaneous calcium release from the sarcoplasmic reticulum and linked to increased adenosine A 2A…”
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9
Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans
Published in Biochemical journal (15-01-2018)“…Reduced protein expression of the cardiac ryanodine receptor type 2 (RyR2) is thought to affect the susceptibility to stress-induced ventricular…”
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10
How to merge observational and physiological data? A case study of motor skills patterns and heart rate in exercise programs for adult women
Published 01-10-2017“…The present study analyzes individual and group heart rate responses in exercising adult women. The specific aim was to compare responses during routine…”
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11
Enhanced plant fault diagnosis based on the characterization of transient stages
Published in Computers & chemical engineering (10-02-2012)“…This paper introduces a data-based fault diagnosis system that includes an enhanced characterization of faults during transient stages. First, data under…”
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12
Low density lipoproteins promote unstable calcium handling accompanied by reduced SERCA2 and connexin-40 expression in cardiomyocytes
Published in PloS one (13-03-2013)“…The damaging effects of high plasma levels of cholesterol in the cardiovascular system are widely known, but little attention has been paid to direct effects…”
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13
Detection, properties, and frequency of local calcium release from the sarcoplasmic reticulum in teleost cardiomyocytes
Published in PloS one (29-08-2011)“…Calcium release from the sarcoplasmic reticulum (SR) plays a central role in the regulation of cardiac contraction and rhythm in mammals and humans but its…”
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14
Identifying Basketball Plays from Sensor Data; Towards a Low-Cost Automatic Extraction of Advanced Statistics
Published in 2017 IEEE International Conference on Data Mining Workshops (ICDMW) (01-11-2017)“…Advanced statistics have proved to be a crucial tool for basketball coaches in order to improve training skills. Indeed, the performance of the team can be…”
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Conference Proceeding -
15
Robust unsupervised detection of action potentials with probabilistic models
Published 30-04-2008“…We develop a robust and fully unsupervised algorithm for the detection of action potentials from extracellularly recorded data. Using the continuous wavelet…”
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16
Identification of intracellular calcium dynamics in stimulated cardiomyocytes
Published in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology (01-01-2010)“…We have developed an automatic method for the analysis and identification of dynamical regimes in intracellular calcium patterns from confocal calcium images…”
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Multilevel analysis of calcium dynamics in stimulated cultures of cardiomyocytes
Published 2013“…We present an automatic method to characterize calcium activity in a culture of cardiac cells from a sequence of microscopy fluorescence images. The approach…”
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18
Human-robot cooperative movement training: learning a novel sensory motor transformation during walking with robotic assistance-as-needed
Published 31-03-2007“…Background A prevailing paradigm of physical rehabilitation following neurologic injury is to "assist-as-needed" in completing desired movements. Several…”
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19
Motor adaptation as a greedy optimization of error and effort
Published 31-03-2007“…thought of as a process in which the nervous system learns to anticipate the environmental forces to eliminate kinematic error. Here we show that motor…”
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