Search Results - "Ben, Robert"

Use of Ice Recrystallization Inhibition Assays to Screen for Compounds That Inhibit Ice Recrystallization by Ampaw, Anna A, Sibthorpe, August, Ben, Robert N

“…Ice recrystallization inhibition assays are used to screen for compounds that possess the ability to inhibit ice recrystallization. The most common of these…”
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Modulating Intracellular Ice Growth with Cell-Permeating Small-Molecule Ice Recrystallization Inhibitors by Poisson, Jessica S, Acker, Jason P, Briard, Jennie G, Meyer, Julia E, Ben, Robert N

“…Ice formation remains central to our understanding of the effects of low temperatures on the biological response of cells and tissues. The formation of ice…”
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Trehalose-Based Polyethers for Cryopreservation and Three-Dimensional Cell Scaffolds by Diaz-Dussan, Diana, Peng, Yi-Yang, Sengupta, Jayeeta, Zabludowski, Rebecca, Adam, Madeleine K, Acker, Jason P, Ben, Robert N, Kumar, Piyush, Narain, Ravin

“…The capability to slow ice growth and recrystallization is compulsory in the cryopreservation of cells and tissues to avoid injuries associated with the…”
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Probing the Mechanism of Action of Small-Molecule Ice Recrystallization Inhibitors Using Proton Nuclear Magnetic Resonance Relaxation by McMunn, Leah E., D’Costa, Adrian S., Bordenave, Nicolas, Ben, Robert N.

“…N-2-Fluorophenyl-d-gluconamide (2FA) improves the recovery and function of cryopreserved biological materials by inhibiting ice recrystallization. However, as…”
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Small Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations by Capicciotti, Chantelle J., Kurach, Jayme D. R., Turner, Tracey R., Mancini, Ross S., Acker, Jason P., Ben, Robert N.

“…In North America, red blood cells (RBCs) are cryopreserved in a clinical setting using high glycerol concentrations (40% w/v) with slow cooling rates…”
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It's a Trap! Aldolase-Prescribed C4 Deoxyradiofluorination Affords Intracellular Trapping and the Tracing of Fructose Metabolism by PET by Kirby, Alexia, Graf, Dominic, Suchý, Mojmír, Calvert, Nicholas D, Charlton, Thomas A, Ben, Robert N, Addison, Christina L, Shuhendler, Adam

“…Fructose metabolism has been implicated in various diseases, including metabolic disorders, neurodegenerative disorders, cardiac disorders, and cancer…”
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Improved Cryopreservation of Human Induced Pluripotent Stem Cell (iPSC) and iPSC-derived Neurons Using Ice-Recrystallization Inhibitors by Alasmar, Salma, Huang, Jez, Chopra, Karishma, Baumann, Ewa, Aylsworth, Amy, Hewitt, Melissa, Sandhu, Jagdeep K, Tauskela, Joseph S, Ben, Robert N, Jezierski, Anna

“…Abstract Human induced pluripotent stem cells (iPSCs) and iPSC-derived neurons (iPSC-Ns) represent a differentiated modality toward developing novel cell-based…”
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It's a Trap! Aldolase-Prescribed C 4 Deoxyradiofluorination Affords Intracellular Trapping and the Tracing of Fructose Metabolism by PET by Kirby, Alexia, Graf, Dominic, Suchý, Mojmír, Calvert, Nicholas D, Charlton, Thomas A, Ben, Robert N, Addison, Christina L, Shuhendler, Adam

“…Fructose metabolism has been implicated in various diseases, including metabolic disorders, neurodegenerative disorders, cardiac disorders, and cancer…”
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Synthesis of natural/13C-enriched d-tagatose from natural/13C-enriched d-fructose by Suchý, Mojmír, Charlton, Thomas A., Ben, Robert N., Shuhendler, Adam J.

“…A concise, easily scalable synthesis of a rare ketohexose, d-tagatose, was developed, that is compatible with the preparation of d-[UL-13C6]tagatose…”
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Small molecule ice recrystallization inhibitors mitigate red blood cell lysis during freezing, transient warming and thawing by Briard, Jennie G., Poisson, Jessica S., Turner, Tracey R., Capicciotti, Chantelle J., Acker, Jason P., Ben, Robert N.

“…During cryopreservation, ice recrystallization is a major cause of cellular damage. Conventional cryoprotectants such as dimethyl sulfoxide (DMSO) and glycerol…”
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Inhibition of ice recrystallization during cryopreservation of cord blood grafts improves platelet engraftment by Jahan, Suria, Adam, Madeleine K., Manesia, Javed K., Doxtator, Emily, Ben, Robert N., Pineault, Nicolas

“…BACKGROUND Platelet engraftment following cord blood (CB) transplantation remains a significant hurdle to this day. The uncontrolled growth of ice, a process…”
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Ice recrystallization inhibitors enable efficient cryopreservation of induced pluripotent stem cells: A functional and transcriptomic analysis by Mommaerts, Kathleen, Okawa, Satoshi, Schmitt, Margaux, Kofanova, Olga, Turner, Tracey R., Ben, Robert N., Del Sol, Antonio, Mathieson, William, Schwamborn, Jens C., Acker, Jason P., Betsou, Fay

“…•Cryopreservation protocols development for induced pluripotent stem cells (iPSCs).•We assessed ice recrystallization inhibitors (IRIs) for iPSCs…”
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Total Synthesis of Homogeneous Antifreeze Glycopeptides and Glycoproteins by Wilkinson, Brendan L., Stone, Robin S., Capicciotti, Chantelle J., Thaysen-Andersen, Morten, Matthews, Jacqueline M., Packer, Nicolle H., Ben, Robert N., Payne, Richard J.

“…Don't freeze! A native chemical ligation–desulfurization strategy has been employed for the convergent synthesis of a library of defined antifreeze…”
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Nurse practitioner/physician collaborative models of care: a scoping review protocol by McGilton, Katherine S, Haslam-Larmer, Lynn, Wills, Aria, Krassikova, Alexandra, Babineau, Jessica, Robert, Ben, Heer, Carrie, McAiney, Carrie, Dobell, Gail, Bethell, Jennifer, Kay, Kelly, Keatings, Margaret, Kaasalainen, Sharon, Feldman, Sid, Sidani, Souraya, Martin-Misener, Ruth

“…Before the COVID-19 pandemic, many long-term care (LTC) homes experienced difficulties in providing residents with access to primary care, typically delivered…”
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Correction to “Trehalose-Based Polyethers for Cryopreservation and 3D Cell Scaffolds” by Diaz-Dussan, Diana, Peng, Yi-Yang, Sengupta, Jayeeta, Zabludowski, Rebecca, Adam, Madeleine K, Acker, Jason P, Ben, Robert N, Kumar, Piyush, Narain, Ravin

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Imaging of the Subtalar Joint by Lopez-Ben, Robert, MD

“…Imaging of the subtalar joint can be challenging because of its complex planar anatomy. This article reviews the anatomy and common anatomic variants as seen…”
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1D Self‐Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide‐Functionalized Perylene Bisimides by Adam, Madeleine K., Jarrett‐Wilkins, Charles, Beards, Michael, Staykov, Emiliyan, MacFarlane, Liam R., Bell, Toby D. M., Matthews, Jacqueline M., Manners, Ian, Faul, Charl F. J., Moens, Pierre D. J., Ben, Robert N., Wilkinson, Brendan L.

“…Antifreeze glycoproteins (AFGPs) are polymeric natural products that have drawn considerable interest in diverse research fields owing to their potent ice…”
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Hydration IndexA Better Parameter for Explaining Small Molecule Hydration in Inhibition of Ice Recrystallization by Tam, Roger Y, Ferreira, Sandra S, Czechura, Pawel, Chaytor, Jennifer L, Ben, Robert N

“…Several simple mono- and disaccharides have been assessed for their ability to inhibit ice recrystallization. Two carbohydrates were found to be effective…”
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The Importance of Hydration for Inhibiting Ice Recrystallization with C-Linked Antifreeze Glycoproteins by Czechura, Pawel, Tam, Roger Y, Dimitrijevic, Elena, Murphy, Anastasia V, Ben, Robert N

“…The role of hydration in modulating solution conformation, molecular recognition, and biological activity of oligosaccharides, proteins, and nucleotides is…”
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QSAR Accelerated Discovery of Potent Ice Recrystallization Inhibitors by Briard, Jennie G., Fernandez, Michael, De Luna, Phil, Woo, Tom. K., Ben, Robert N.

“…Ice recrystallization is the main contributor to cell damage and death during the cryopreservation of cells and tissues. Over the past five years, many small…”
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