Association between interleukin gene polymorphisms and susceptibility to gastric cancer in the Qinghai population

Objective To investigate the associations between interleukin (IL) gene polymorphisms and susceptibility to gastric cancer in the Qinghai population, China. Methods Patients with gastric cancer and cancer-free controls were enrolled into the study from Qinghai Provincial People’s Hospital between Se...

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Bibliographic Details
Published in:	Journal of international medical research Vol. 49; no. 5; p. 3000605211004755
Main Authors:	Song, Xiaoyan, Wang, Dongmei, Ben, Baji, Xiao, Chenghua, Bai, Liyan, Xiao, Han, Zhang, Wenyan, Li, Wanchao, Jia, Jingying, Qi, Yujuan
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-05-2021 Sage Publications Ltd SAGE Publishing
Subjects:	Case-Control Studies China Clinical Research Report Cytokines Gastric cancer Gene Frequency Genetic Predisposition to Disease Genotype Genotype & phenotype Humans Interleukins Polymorphism Polymorphism, Single Nucleotide - genetics Stomach Neoplasms - genetics China IL-1B rs1143634 cancer risk interleukin (IL) genes susceptibility Gastric cancer polymorphisms
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Summary:	Objective To investigate the associations between interleukin (IL) gene polymorphisms and susceptibility to gastric cancer in the Qinghai population, China. Methods Patients with gastric cancer and cancer-free controls were enrolled into the study from Qinghai Provincial People’s Hospital between September 2016 and September 2018. Single nucleotide polymorphisms (SNPs) were genotyped with the Sequenom MassARRAY® SNP genotype system. The Hardy–Weinberg equilibrium in allele and genotype frequencies, and general characteristics between patients with gastric cancer and cancer-free controls, were evaluated using χ2-test. Potential associations between interleukin gene variants and the risk of gastric cancer were analysed by logistic regression. Results Among eight candidate SNPs, the allele and genotype frequency distribution of IL-1B rs1143634 polymorphism was significantly different between patients with gastric cancer (n = 190) and cancer-free controls (n = 186). The IL-1B rs1143634 GA genotype and IL-1B rs1143634 GA + AA genotype were associated with a reduced risk of gastric cancer, however, the remaining SNPs were not statistically associated with gastric cancer risk in the Qinghai population. Conclusion The IL-1B rs1143634 polymorphism might be associated with a decreased risk of gastric cancer, and may be a protective factor against gastric cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	0300-0605 1473-2300
DOI:	10.1177/03000605211004755