Search Results - "Bemis, Jean E."

protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9 by Nakamaru, Yuji, Vuppusetty, Chaitanya, Wada, Hiroo, Milne, Jill C, Ito, Misako, Rossios, Christos, Elliot, Mark, Hogg, James, Kharitonov, Sergei, Goto, Hajime, Bemis, Jean E, Elliott, Peter, Barnes, Peter J, Ito, Kazuhiro

“…Inappropriate elevation of matrix metalloproteinase-9 (MMP9) is reported to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD)…”
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Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes by Jin, Lei, Wei, Wentao, Jiang, Yaobin, Peng, Hao, Cai, Jianhua, Mao, Chen, Dai, Han, Choy, Wendy, Bemis, Jean E., Jirousek, Michael R., Milne, Jill C., Westphal, Christoph H., Perni, Robert B.

“…SIRT3 is a major mitochondrial NAD+-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has…”
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Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3 by Jin, Lei, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Morrison, Michael, Xia, Yu, Wang, Xiaohong, Xu, Yihua, Yang, Yuecheng, Smith, Jesse J., Hoffmann, Ethan, Carney, David P., Perni, Robert B., Jirousek, Michael R., Bemis, Jean E., Milne, Jill C., Sinclair, David A., Westphal, Christoph H.

“…SIRT3 is a key mitochondrial protein deacetylase proposed to play key roles in regulating mitochondrial metabolism but there has been considerable debate about…”
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Discovery of oxazolo[4,5- b]pyridines and related heterocyclic analogs as novel SIRT1 activators by Bemis, Jean E., Vu, Chi B., Xie, Roger, Nunes, Joseph J., Ng, Pui Yee, Disch, Jeremy S., Milne, Jill C., Carney, David P., Lynch, Amy V., Jin, Lei, Smith, Jesse J., Lavu, Siva, Iffland, Andre, Jirousek, Michael R., Perni, Robert B.

“…The identification and SAR of novel small molecule activators of SIRT1, which are structurally distinct and more potent than resveratrol ( 1), are described…”
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes by Choy, Wendy, Sinclair, David A, Lambert, Philip D, Gagne, David J, Lynch, Amy V, Milne, Jill C, Bemis, Jean E, Boss, Olivier, Perni, Robert B, Schenk, Simon, Carney, David P, Yang, Hongying, Ng, Pui Yee, Iffland, Andre, Smith, Jesse J, Elliott, Peter J, Vu, Chi B, Xie, Roger, Galonek, Heidi, Israelian, Kristine, Lavu, Siva, Medvedik, Oliver, Olefsky, Jerrold M, Disch, Jeremy S, Nunes, Joseph J, Jirousek, Michael R, Westphal, Christoph H, Jin, Lei

“…Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an…”
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Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid by Vu, Chi B, Bemis, Jean E, Benson, Ericka, Bista, Pradeep, Carney, David, Fahrner, Richard, Lee, Diana, Liu, Feng, Lonkar, Pallavi, Milne, Jill C, Nichols, Andrew J, Picarella, Dominic, Shoelson, Adam, Smith, Jesse, Ting, Amal, Wensley, Allison, Yeager, Maisy, Zimmer, Michael, Jirousek, Michael R

“…This report describes the synthesis and preliminary biological characterization of novel fatty acid niacin conjugates and fatty acid salicylate conjugates…”
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Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators by Vu, Chi B, Bemis, Jean E, Disch, Jeremy S, Ng, Pui Yee, Nunes, Joseph J, Milne, Jill C, Carney, David P, Lynch, Amy V, Smith, Jesse J, Lavu, Siva, Lambert, Philip D, Gagne, David J, Jirousek, Michael R, Schenk, Simon, Olefsky, Jerrold M, Perni, Robert B

“…A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD+-dependent deacetylase SIRT1, a potential new therapeutic target to treat various…”
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Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck:  Synthesis, SAR, and in Vivo Anti-Inflammatory Activity by DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Buchanan, John L, Buckner, William H, Cee, Victor J, Chai, Lilly, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Geuns-Meyer, Stephanie D, Gore, Anu, Gu, Yan, Henkle, Brad, Hodous, Brian L, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, Masse, Craig E, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian

“…The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in…”
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Discovery of 4-amino-5,6-biaryl-furo[2,3- d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR by DiMauro, Erin F., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., Boucher, Christina, Buchanan, John L., Buckner, William H., Cheng, Alan, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Marshall, Teresa L., Martin, Matthew W., McGowan, David C., Schneider, Stephen, Turci, Susan M., White, Ryan D., Zhu, Xiaotian

“…4-Amino-5,6-biaryl-furo[2,3- d]pyrimidines were identified as potent non-selective inhibitors of Lck. A novel, divergent, and practical synthetic route was…”
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Discovery of novel 2,3-diarylfuro[2,3- b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties by Martin, Matthew W., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., McGowan, David C., White, Ryan D., Buchanan, John L., DiMauro, Erin F., Boucher, Christina, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Schneider, Stephen, Turci, Susan M., Zhu, Xiaotian

“…2,3-Diarylfuro[2,3- b ]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity…”
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Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure–Activity Relationships, and Inhibition of in Vivo T Cell Activation by DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Chai, Lilly, Chaffee, Stuart C, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Gore, Anu, Gu, Yan, Henkle, Brad, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian

“…The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells…”
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Crystal Structures of Human SIRT[subscript 3] Displaying Substrate-induced Conformational Changes by Jin, Lei, Wei, Wentao, Jiang, Yaobin, Peng, Hao, Cai, Jianhua, Mao, Chen, Dai, Han, Choy, Wendy, Bemis, Jean E., Jirousek, Michael R., Milne, Jill C., Westphal, Christoph H., Perni, Robert B.

“…SIRT3 is a major mitochondrial NAD{sup +}-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production…”
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Erratum to “Discovery of novel 2,3-diarylfuro[2,3- b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties” [Bioorg. Med. Chem. Lett. 17 (2007) 2299–2304] by Martin, Matthew W., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., McGowan, David C., White, Ryan D., Buchanan, John L., DiMauro, Erin F., Boucher, Christina, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Schneider, Stephen, Turci, Susan M., Zhu, Xiaotian

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Erratum to “Discovery of 4-amino-5,6-biaryl-furo[2,3- d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR” [Bioorg. Med. Chem. Lett. 17 (2007) 2305–2309] by DiMauro, Erin F., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., Boucher, Christina, Buchanan, John L., Buckner, William H., Cheng, Alan, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Marshall, Teresa L., Martin, Matthew W., McGowan, David C., Schneider, Stephen, Turci, Susan M., White, Ryan D., Zhu, Xiaotian

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