Search Results - "Beltran, Pedro"

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition by Crespo-Garcia, Sergio, Tsuruda, Pamela R., Dejda, Agnieszka, Ryan, Rathi D., Fournier, Frederik, Chaney, Shawnta Y., Pilon, Frederique, Dogan, Taner, Cagnone, Gael, Patel, Priyanka, Buscarlet, Manuel, Dasgupta, Sonali, Girouard, Gabrielle, Rao, Surabhi R., Wilson, Ariel M., O’Brien, Robert, Juneau, Rachel, Guber, Vera, Dubrac, Alexandre, Beausejour, Christian, Armstrong, Scott, Mallette, Frederick A., Yohn, Christopher B., Joyal, Jean-Sebastien, Marquess, Dan, Beltran, Pedro J., Sapieha, Przemyslaw

“…Attenuating pathological angiogenesis in diseases characterized by neovascularization such as diabetic retinopathy has transformed standards of care. Yet…”
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AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer by Giffin, Michael J, Cooke, Keegan, Lobenhofer, Edward K, Estrada, Juan, Zhan, Jinghui, Deegen, Petra, Thomas, Melissa, Murawsky, Christopher M, Werner, Jonathan, Liu, Siyuan, Lee, Fei, Homann, Oliver, Friedrich, Matthias, Pearson, Joshua T, Raum, Tobias, Yang, Yajing, Caenepeel, Sean, Stevens, Jennitte, Beltran, Pedro J, Canon, Jude, Coxon, Angela, Bailis, Julie M, Hughes, Paul E

“…Small-cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with a high relapse rate, limited therapeutic options, and poor prognosis. We investigated…”
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The Spanish version of the Job Crafting Scale by Bakker, Arnold B, Ficapal-Cusí, Pilar, Torrent-Sellens, Joan, Boada-Grau, Joan, Hontangas-Beltrán, Pedro M

“…A literature review reveals that there is no measure of job crafting available in Spanish. This paper presents the translation, adaptation and validation of a…”
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Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice by Mao, Kai, Quipildor, Gabriela Farias, Tabrizian, Tahmineh, Novaj, Ardijana, Guan, Fangxia, Walters, Ryan O., Delahaye, Fabien, Hubbard, Gene B., Ikeno, Yuji, Ejima, Keisuke, Li, Peng, Allison, David B., Salimi-Moosavi, Hossein, Beltran, Pedro J., Cohen, Pinchas, Barzilai, Nir, Huffman, Derek M.

“…Diminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and…”
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Modulation of Glucose Production by Central Insulin Requires IGF-1 Receptors in AgRP Neurons by Farias Quipildor, Gabriela, Mao, Kai, Beltran, Pedro J, Barzilai, Nir, Huffman, Derek M

“…Similar to insulin, central administration of IGF-1 can suppress hepatic glucose production (HGP), but it is unclear whether this effect is mediated via…”
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Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results by Crespo-Garcia, Sergio, Fournier, Frédérik, Diaz-Marin, Roberto, Klier, Sharon, Ragusa, Derek, Masaki, Lauren, Cagnone, Gael, Blot, Guillaume, Hafiane, Ikhlas, Dejda, Agnieszka, Rizk, Rana, Juneau, Rachel, Buscarlet, Manuel, Chorfi, Sarah, Patel, Priyanka, Beltran, Pedro J., Joyal, Jean-Sebastien, Rezende, Flavio A., Hata, Masayuki, Nguyen, Alex, Sullivan, Lynne, Damiano, Jason, Wilson, Ariel M., Mallette, Frédérick A., David, Nathaniel E., Ghosh, Anirvan, Tsuruda, Pamela R., Dananberg, Jamie, Sapieha, Przemyslaw

“…Compromised vascular endothelial barrier function is a salient feature of diabetic complications such as sight-threatening diabetic macular edema (DME)…”
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Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR by Sharma, Alok K., Pei, Jun, Yang, Yue, Dyba, Marcin, Smith, Brian, Rabara, Dana, Larsen, Erik K., Lightstone, Felice C., Esposito, Dominic, Stephen, Andrew G., Wang, Bin, Beltran, Pedro J., Wallace, Eli, Nissley, Dwight V., McCormick, Frank, Maciag, Anna E.

“…Individual oncogenic KRAS mutants confer distinct differences in biochemical properties and signaling for reasons that are not well understood. KRAS activity…”
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Functional genomics of abiotic environmental adaptation in lacertid lizards and other vertebrates by Wollenberg Valero, Katharina C., Garcia‐Porta, Joan, Irisarri, Iker, Feugere, Lauric, Bates, Adam, Kirchhof, Sebastian, Jovanović Glavaš, Olga, Pafilis, Panayiotis, Samuel, Sabrina F., Müller, Johannes, Vences, Miguel, Turner, Alexander P., Beltran‐Alvarez, Pedro, Storey, Kenneth B.

“…Understanding the genomic basis of adaptation to different abiotic environments is important in the context of climate change and resulting short‐term…”
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Discovery of 1H‑Pyrazol-3(2H)‑ones as Potent and Selective Inhibitors of Protein Kinase R‑like Endoplasmic Reticulum Kinase (PERK) by Smith, Adrian L, Andrews, Kristin L, Beckmann, Holger, Bellon, Steven F, Beltran, Pedro J, Booker, Shon, Chen, Hao, Chung, Young-Ah, D’Angelo, Noel D, Dao, Jennifer, Dellamaggiore, Kenneth R, Jaeckel, Peter, Kendall, Richard, Labitzke, Katja, Long, Alexander M, Materna-Reichelt, Silvia, Mitchell, Petia, Norman, Mark H, Powers, David, Rose, Mark, Shaffer, Paul L, Wu, Michelle M, Lipford, J. Russell

“…The structure-based design and optimization of a novel series of selective PERK inhibitors are described resulting in the identification of 44 as a potent,…”
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Career construction and emotional intelligence as antecedents of vocational identity by Merino-Tejedor, Enrique, Hontangas-Beltrán, Pedro M, Pérez-González, Juan Carlos

“…Este artículo tiene un doble objetivo científico: Por un lado, se pretende llevar a cabo una validación del Inventario de Construcción de la Carrera para…”
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Antibody‐mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo by Moody, Gordon, Belmontes, Brian, Masterman, Stephanie, Wang, Wei, King, Chadwick, Murawsky, Chris, Tsuruda, Trace, Liu, Shuying, Radinsky, Robert, Beltran, Pedro J.

“…Gas6 and its receptors Axl, Mer and Tyro‐3 (TAM) are highly expressed in human malignancy suggesting that signaling through this axis may be tumor‐promoting…”
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AMG 479, a fully human anti–insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells by Beltran, Pedro J, Mitchell, Petia, Chung, Young-A, Cajulis, Elaina, Lu, John, Belmontes, Brian, Ho, Joanne, Tsai, Mei Mei, Zhu, Min, Vonderfecht, Steven, Baserga, Renato, Kendall, Richard, Radinsky, Robert, Calzone, Frank J

“…Pancreatic carcinoma is a leading cause of cancer deaths, and recent clinical trials of a number of oncology therapeutics have not substantially improved…”
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Epitope-specific mechanisms of IGF1R inhibition by ganitumab by Calzone, Frank J, Cajulis, Elaina, Chung, Young-Ah, Tsai, Mei-Mei, Mitchell, Petia, Lu, John, Chen, Ching, Sun, Jilin, Radinsky, Robert, Kendall, Richard, Beltran, Pedro J

“…Therapeutic antibodies targeting the IGF1R have shown diverse efficacy and safety signals in oncology clinical trials. The success of these agents as future…”
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Hardiness as a moderator variable between the Big-Five Model and work effort by Merino-Tejedor, Enrique, Hontangas-Beltrán, Pedro M., Boada-Grau, Joan, Lucas-Mangas, Susana

“…•People with high levels of the Five Factor traits show higher levels of work effort.•Hardiness has a moderating effect between the Five Factor Model and work…”
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Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia by Wangüemert, Fernando, PhD, MD, Bosch Calero, Cristina, MSc, Pérez, Carmelo, BD, Campuzano, Oscar, PhD, Beltran-Alvarez, Pedro, PhD, Scornik, Fabiana S., PhD, Iglesias, Anna, MSc, Berne, Paola, MD, Allegue, Catarina, PhD, Ruiz Hernandez, Pablo M., PhD, MD, Brugada, Josep, PhD, MD, Pérez, Guillermo J., PhD, Brugada, Ramon, PhD, MD

“…Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family…”
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Targeting IGF-IR with ganitumab inhibits tumorigenesis and increases durability of response to androgen-deprivation therapy in VCaP prostate cancer xenografts by Fahrenholtz, Cale D, Beltran, Pedro J, Burnstein, Kerry L

“…Prostate cancer is the most commonly diagnosed malignancy in men. While tumors initially respond to androgen-deprivation therapy, the standard care for…”
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OncoVEX mGM-CSF expands tumor antigen-specific CD8+ T-cell response in preclinical models by Estrada, Juan, Zhan, Jinghui, Mitchell, Petia, Werner, Jonathan, Beltran, Pedro J, DeVoss, Jason, Qing, Jing, Cooke, Keegan S

“…Checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1)/programmed cell death ligand 1…”
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Efficacy of ganitumab (AMG 479), alone and in combination with rapamycin, in Ewing's and osteogenic sarcoma models by Beltran, Pedro J, Chung, Young-Ah, Moody, Gordon, Mitchell, Petia, Cajulis, Elaina, Vonderfecht, Steven, Kendall, Richard, Radinsky, Robert, Calzone, Frank J

“…Ewing's and osteogenic sarcoma are two of the leading causes of cancer deaths in children and adolescents. Recent data suggest that sarcomas may depend on the…”
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Ganitumab (AMG 479) Inhibits IGF-II-Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy by BELTRAN, Pedro J, CALZONE, Frank J, GUORONG YANG, JINGWEI QI, SLAMON, Dennis J, KONECNY, Gottfried E, MITCHELL, Petia, CHUNG, Young-Ah, CAJULIS, Elaina, MOODY, Gordon, BELMONTES, Brian, LI, Chi-Ming, VONDERFECHT, Steven, VELCULESCU, Victor E

“…Insulin-like growth factor 1 receptor (IGF-IR) has been implicated in the pathogenesis of ovarian cancer. Ganitumab is an investigational, fully human…”
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A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae by Trott, Jamie, Beltran-Alvarez, Pedro, Bonn, Stefan, Fernández-Tornero, Carlos, Rybin, Vladimir, Bork, Peer, Betts, Matthew J, Russell, Robert B, Gavin, Anne-Claude, Kaksonen, Marko, Jensen, Lars Juhl, Aguilar-Gurrieri, Carmen, Kuhn, Michael, Müller, Christoph W, Gvozdenovic-Jeremic, Jelena, Maeda, Kenji, Matetzki, Christian, Gallego, Oriol

“…Protein–metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein–lipid interactions…”
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