Search Results - "Beltrão, Eduardo Isidoro Carneiro"
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Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives
Published in International journal of molecular sciences (09-06-2015)“…In this work, the acridine nucleus was used as a lead-compound for structural modification by adding different substituted thiosemicarbazide moieties. Eight…”
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2
High FUT3 expression is a marker of lower overall survival of breast cancer patients
Published in Glycoconjugate journal (01-04-2020)“…The complex enzyme network responsible for glycan synthesis suffers significant changes during the first steps of tumor development, leading to the early…”
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3
Synthesis, DNA binding and topoisomerase I inhibition activity of thiazacridine and imidazacridine derivatives
Published in Molecules (Basel, Switzerland) (06-12-2013)“…Thiazacridine and imidazacridine derivatives have shown promising results as tumors suppressors in some cancer cell lines. For a better understanding of the…”
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Targeting the Cryptococcus neoformans var. grubii cell wall using lectins: study of the carbohydrate-binding domain
Published in Molecules (Basel, Switzerland) (25-02-2015)“…Cryptococcus neoformans var. grubii is considered to be the major cause of cryptococcosis in immunosuppressed patients. Understanding cell wall glycoproteins…”
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5
The challenge of determining the impact of FUT3 tumor-associated polymorphism rs2306969 (-6951 C> T) in invasive breast cancer cells
Published in Molecular biology reports (01-06-2019)“…FUT3 gene is responsible for encode an homonymous α1,3/4-fucosyltransferase involved in the synthesis of sialyl-Lewis antigens. FUT3-fucosylated…”
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Effect of maternal diet rich in omega-6 and omega-9 fatty acids on the liver of LDL receptor-deficient mouse offspring
Published in Birth defects research. Part B. Developmental and reproductive toxicology (01-04-2010)“…BACKGROUND: Omega‐6 fatty acids are important to fetal development. However, during gestation/lactation, these fatty acids may contribute toward the…”
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N-Acetylglucosaminyltransferase III (GnT-III) but not N-Acetylgalactosaminyltransferase-6 and 8 are Differentially Expressed in Invasive and In Situ Ductal Carcinoma of the Breast
Published in Pathology oncology research (01-04-2019)“…Mammary carcinoma is the most common malignant tumor in women, and it is the leading cause of mortality. In tumor context, glycosylation promotes post…”
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Potential effects of Cramoll 1,4 lectin on murine Schistosomiasis mansoni
Published in Acta tropica (01-05-2011)“…The article investigates the anti-S. mansoni activity promoted by Cramoll 1,4 lectin isolated with high yield from Cratylia mollis Mart. seeds, a plant native…”
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Evaluation of WGA and Concanavalin A (Con A) lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system
Published in Revista do Instituto de Medicina Tropical de São Paulo (01-06-2013)“…Colonic lesions are predominant in patients with schistosomiasis. However, carbohydrate alterations in colonic schistosomiasis remain unclear. Lectin-ligands…”
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10
Chemiluminescent Detection of Carbohydrates in the Tumoral Breast Diseases
Published in Applied biochemistry and biotechnology (01-01-2012)“…Nowadays, there is an increase of investigations into the fibroadenoma, mainly because some studies have shown that the occurrence of fibroadenoma is linked to…”
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11
Implications on glycobiological aspects of tumor hypoxia in breast ductal carcinoma in situ
Published in Medical molecular morphology (01-06-2013)“…Breast carcinoma is one of the most common neoplasia and the first cause of women cancer related deaths worldwide. In the past few years with diagnostic…”
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12
Comparative Analysis of Extracellular Matrix and Cellular Carbohydrate Expression in the Sporotrichosis and Chromoblastomycosis
Published in Mycopathologia (1975) (01-06-2011)“…This work was based on the analysis of digital images of histochemical profile from subcutaneous lesions in sporotrichosis (ST) and chromoblastomycosis (CM)…”
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13
Dimethyl‐2‐[(acridin‐9‐yl)methylidene]‐malonate as fluorescent probe for histochemical analysis
Published in Microscopy research and technique (01-06-2017)“…Fluorescent compounds have been widely used for biomolecule labeling in cytochemistry and histochemistry analysis. Here, it is described the optical properties…”
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14
Comparing the Immunoexpression of FUT3 and FUT6 between Prostatic Adenocarcinoma and Benign Prostatic Hyperplasia
Published in ACTA HISTOCHEMICA ET CYTOCHEMICA (01-01-2013)“…Prostatic Adenocarcinoma (PA) and Benign Prostatic Hyperplasia (BPH) have their etiology not fully understood mainly in glycidic aspects. Glycan changes are…”
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15
PVA-Glutaraldehyde as support for lectin immobilization and affinity chromatography
Published in Acta scientiarum. Biological sciences (08-12-2016)“…Immobilized lectins are a powerful biotechnological tool for separation and isolation of glycoconjugates. In the present study, polyvinyl alcohol (PVA) and…”
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Carbohydrate profiling of fungal cell wall surface glycoconjugates of Trichophyton tonsurans and other keratinophilic filamentous fungi using lectins
Published in Mycoses (01-11-2011)“…Summary Various researchers have concluded that lectins are useful reagents for the study of fungal cell wall surface glycoconjugates. In this study, we…”
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17
DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?
Published in Biomedicine & pharmacotherapy (01-12-2017)“…DNA is considered one of the most promising targets of molecules with anticancer activity potential. Its key role in various cell division mechanisms, which…”
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Polysiloxane–polyvinyl alcohol discs as support for antibody immobilization: Ultra-structural and physical–chemical characterization
Published in Reactive & functional polymers (2008)“…A semi-interpenetrated polymer network of posiloxane and polyvinyl alcohol (POS–PVA) was synthesized through sol–gel process in the form of discs and used as…”
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New spiro-acridines: DNA interaction, antiproliferative activity and inhibition of human DNA topoisomerases
Published in International journal of biological macromolecules (01-11-2016)“…Two new spiro-acridines were synthesized by introducing cyano-N-acylhydrazone between the acridine and phenyl rings followed by spontaneous cyclization. The…”
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Lectin-carbohydrate complex evaluation by chemiluminescence
Published in Analytical biochemistry (01-05-2018)“…In order to characterize the affinity between specific carbohydrate-binding proteins such as lectins, a model is proposed to study these interactions using a…”
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