Search Results - "Belsham, Denise D."

Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173 by Treen, Alice K, Luo, Vicky, Belsham, Denise D

“…Reproductive function is coordinated by kisspeptin (Kiss) and GnRH neurons. Phoenixin-20 amide (PNX) is a recently described peptide found to increase…”
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Impact of nutrients on circadian rhythmicity by Oosterman, Johanneke E, Kalsbeek, Andries, la Fleur, Susanne E, Belsham, Denise D

“…The suprachiasmatic nucleus (SCN) in the mammalian hypothalamus functions as an endogenous pacemaker that generates and maintains circadian rhythms throughout…”
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Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons by Wellhauser, Leigh, Belsham, Denise D

“…Overnutrition and the ensuing hypothalamic inflammation is a major perpetuating factor in the development of metabolic diseases, such as obesity and diabetes…”
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Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation by Mayer, Christopher M, Belsham, Denise D

“…Hypothalamic insulin signaling is essential to the maintenance of glucose and energy homeostasis. During pathological states, such as obesity and type 2…”
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Bisphenol A Induces Agrp Gene Expression in Hypothalamic Neurons through a Mechanism Involving ATF3 by Loganathan, Neruja, McIlwraith, Emma K, Belsham, Denise D

“…Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical and obesogen. Although limited evidence exists of the effects of BPA on hypothalamic…”
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Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons by Oosterman, Johanneke E, Belsham, Denise D

“…Specific neurons in the hypothalamus are regulated by peripheral hormones and nutrients to maintain proper metabolic control. It is unclear if nutrients can…”
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Molecular Basis for the Activation of Gonadotropin-Inhibitory Hormone Gene Transcription by Corticosterone by Son, You Lee, Ubuka, Takayoshi, Narihiro, Misato, Fukuda, Yujiro, Hasunuma, Itaru, Yamamoto, Kazutoshi, Belsham, Denise D, Tsutsui, Kazuyoshi

“…The inhibitory effect of stress on reproductive function is potentially mediated by high concentrations of circulating glucocorticoids (GCs) acting via the GC…”
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RNA-Binding Protein Motifs Predict microRNA Secretion and Cellular Retention in Hypothalamic and Other Cell Types by He, Wenyuan, Belsham, Denise D

“…Cellular microRNAs (miRNAs) can be selectively secreted or retained, adding another layer to their critical role in regulating human health and disease. To…”
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Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity by Diano, Sabrina, Liu, Zhong-Wu, Jeong, Jin Kwon, Dietrich, Marcelo O, Ruan, Hai-Bin, Kim, Esther, Suyama, Shigetomo, Kelly, Kaitlin, Gyengesi, Erika, Arbiser, Jack L, Belsham, Denise D, Sarruf, David A, Schwartz, Michael W, Bennett, Anton M, Shanabrough, Marya, Mobbs, Charles V, Yang, Xiaoyong, Gao, Xiao-Bing, Horvath, Tamas L

“…Tamas Horvath and his colleagues show that in states of obesity activation of the transcription factor PPAR-γ in POMC neurons occurs, resulting in an increase…”
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Glucocorticoid receptor-mediated regulation of Rfrp (GnIH) and Gpr147 (GnIH-R) synthesis in immortalized hypothalamic neurons by Gojska, Nicole M., Belsham, Denise D.

“…[Display omitted] •Novel hypothalamic cell line expressing GnIH (Rfrp-3) and GnIH-R (GPR147).•Glucocorticoid (GC) dexamethasone regulates both GnIH and…”
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Phoenixin Expression Is Regulated by the Fatty Acids Palmitate, Docosahexaenoic Acid and Oleate, and the Endocrine Disrupting Chemical Bisphenol A in Immortalized Hypothalamic Neurons by McIlwraith, Emma K, Loganathan, Neruja, Belsham, Denise D

“…Phoenixin (PNX) is a newly identified reproductive peptide required for the estrous cycle. It is most highly expressed in the hypothalamus, where it is a…”
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Beneficial Effects of Metformin and/or Salicylate on Palmitate- or TNFα-Induced Neuroinflammatory Marker and Neuropeptide Gene Regulation in Immortalized NPY/AgRP Neurons by Ye, Wenqing, Ramos, Ernesto H, Wong, Brian C, Belsham, Denise D

“…Neuropeptide Y (NPY)/Agouti-related peptide (AgRP)-expressing neurons in the hypothalamus induce feeding and decrease energy expenditure. With consumption of a…”
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The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis by WEIJUAN SHAO, DINGYAN WANG, XIAOYAN WEN, QINGHUA WANG, TIANRU JIN, CHIANG, Yu-Ting, IP, Wilfred, LINGYUN ZHU, FENGHAO XU, COLUMBUS, Joshua, BELSHAM, Denise D, IRWIN, David M, HAIBO ZHANG

“…The type 2 diabetes risk gene TCF7L2 is the effector of the Wnt signaling pathway. We found previously that in gut endocrine L-cell lines, TCF7L2 controls…”
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Eliminating SF-1 (NR5A1) Sumoylation In Vivo Results in Ectopic Hedgehog Signaling and Disruption of Endocrine Development by Lee, Florence Y., Faivre, Emily J., Suzawa, Miyuki, Lontok, Erik, Ebert, Daniel, Cai, Fang, Belsham, Denise D., Ingraham, Holly A.

“…Sumoylation is generally considered a repressive mark for many transcription factors. However, the in vivo importance of sumoylation for any given substrate…”
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Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons by Mayer, Christopher M., Belsham, Denise D.

“…Insulin plays a key role in the maintenance of nutrient homeostasis through central regulation of neuropeptides. Neuropeptide Y (NPY) and agouti-related…”
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Cellular Insulin Resistance Disrupts Leptin-Mediated Control of Neuronal Signaling and Transcription by Nazarians-Armavil, Anaies, Menchella, Jonathan A, Belsham, Denise D

“…Central resistance to the actions of insulin and leptin is associated with the onset of obesity and type 2 diabetes mellitus, whereas leptin and insulin…”
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Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters by Martino, Tami A, Oudit, Gavin Y, Herzenberg, Andrew M, Tata, Nazneen, Koletar, Margaret M, Kabir, Golam M, Belsham, Denise D, Backx, Peter H, Ralph, Martin R, Sole, Michael J

“…Sleep deprivation, shift work, and jet lag all disrupt normal biological rhythms and have major impacts on health; however, circadian disorganization has never…”
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Kisspeptin Directly Regulates Neuropeptide Y Synthesis and Secretion via the ERK1/2 and p38 Mitogen-Activated Protein Kinase Signaling Pathways in NPY-Secreting Hypothalamic Neurons by Kim, Ginah L, Dhillon, Sandeep S, Belsham, Denise D

“…Kisspeptin is a key component of reproduction that directly stimulates GnRH neurons. However, recent studies indicate that kisspeptin can indirectly stimulate…”
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Glucagon-Like Peptide-1 Receptor Agonist, Exendin-4, Regulates Feeding-Associated Neuropeptides in Hypothalamic Neurons in Vivo and in Vitro by Dalvi, Prasad S, Nazarians-Armavil, Anaies, Purser, Matthew J, Belsham, Denise D

“…Exendin-4, a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist, is a potential regulator of feeding behavior through its ability to inhibit gastric…”
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NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons by Tran, Andy, He, Wenyuan, Jiang, Nan, Chen, Jim T C, Belsham, Denise D

“…Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases,…”
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