Search Results - "Belov, Dmitry S."

Stereospecific Ring‐Opening Metathesis Polymerization of Norbornene Catalyzed by Iron Complexes by Belov, Dmitry S., Mathivathanan, Logesh, Beazley, Melanie J., Martin, William Blake, Bukhryakov, Konstantin V.

“…Developing well‐defined iron‐based catalysts for olefin metathesis would be a breakthrough achievement in the field not only to replace existing catalysts by…”
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Combustion Synthesis and Reactive Spark Plasma Sintering of Non-Equiatomic CoAl-Based High Entropy Intermetallics by Kuskov, Kirill Vasilevich, Nepapushev, Andrey A, Aydinyan, Sofiya, Shaysultanov, Dmitry G, Stepanov, Nikita D, Nazaretyan, Khachik, Kharatyan, Suren, Zakharova, Elena V, Belov, Dmitry S, Moskovskikh, Dmitry O

“…The present work reports the direct production of a high-entropy (HE) intermetallic CoNi Fe Cr Al material with a B2 structure from mechanically activated…”
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Oxidative Dearomatization of 4,5,6,7-Tetrahydro-1H-indoles Obtained by Metal- and Solvent-Free Thermal 5-endo-dig Cyclization: The Route to Erythrina and Lycorine Alkaloids by Andreev, Ivan A., Ratmanova, Nina K., Novoselov, Anton M., Belov, Dmitry S., Seregina, Irina F., Kurkin, Alexander V.

“…A facile one‐pot approach based on a thermally induced metal‐ and solvent‐free 5‐endo‐dig cyclization reaction of the amino propargylic alcohols in combination…”
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Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity by Curreli, Francesca, Belov, Dmitry S, Ramesh, Ranjith R, Patel, Naisargi, Altieri, Andrea, Kurkin, Alexander V, Debnath, Asim K

“…Since our first discovery of a CD4-mimic, NBD-556, which targets the Phe43 cavity of HIV-1 gp120, we and other groups made considerable progress in designing…”
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Synthesis of Bicyclic Proline Derivatives by the Aza-Cope-Mannich Reaction: Formal Synthesis of (±)-Acetylaranotin by Belov, Dmitry S., Ratmanova, Nina K., Andreev, Ivan A., Kurkin, Alexander V.

“…Herein we suggest an approach to oxygenated bicyclic amino acids based on an aza‐Cope–Mannich rearrangement. Seven distinct amino acid scaffolds analogous to…”
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Highly Stereoselective and Scalable Synthesis of trans-Fused Octahydrocyclohepta[b]pyrrol-4(1H)‑ones via the Aza-Cope–Mannich Rearrangement in Racemic and Enantiopure Forms by Belov, Dmitry S, Lukyanenko, Evgeny R, Kurkin, Alexander V, Yurovskaya, Marina A

“…We have developed an efficient and stereoselective route to trans-fused octahydrocyclohepta[b]pyrrol-4(1H)-ones. The key features of our synthesis include the…”
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A Small‐Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity by Massignan, Tania, Sangiovanni, Valeria, Biggi, Silvia, Stincardini, Claudia, Elezgarai, Saioa R., Maietta, Giulia, Andreev, Ivan A., Ratmanova, Nina K., Belov, Dmitry S., Lukyanenko, Evgeny R., Belov, Grigory M., Barreca, Maria Letizia, Altieri, Andrea, Kurkin, Alexander V., Biasini, Emiliano

“…Into the fold: Prion diseases are neurodegenerative disorders characterized by the accumulation in the brain of a self‐replicating, misfolded isoform (PrPSc)…”
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Ring‐Closing Olefin Metathesis Catalyzed by Well‐Defined Vanadium Alkylidene Complexes by Belov, Dmitry S., Tejeda, Gabriela, Tsay, Charlene, Bukhryakov, Konstantin V.

“…Vanadium‐based catalysts have shown activity and selectivity in ring‐opening metathesis polymerization of strained cyclic olefins comparable to those of Ru,…”
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Decreasing the Bond Order between Vanadium and Oxo Ligand to Form 3d Schrock Carbynes by Hernandez, Shirley, Belov, Dmitry S., Krivovicheva, Vasilisa, Senthil, Shuruthi, Bukhryakov, Konstantin V.

“…Preserving vanadium in a high oxidation state during chemical transformations can be challenging due to the oxidizing nature of V­(+5) species. Oxo and similar…”
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Olefin Metathesis by First‐Row Transition Metals by Belov, Dmitry S., Tejeda, Gabriela, Bukhryakov, Konstantin V.

“…Catalytic olefin metathesis based on the second‐ and third‐row transition metals has become one of the most powerful transformations in modern organic…”
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Synthesis of Vanadium Oxo Alkylidene Complex and Its Reactivity in Ring-Closing Olefin Metathesis Reactions by Belov, Dmitry S, Fenoll, Didac A, Chakraborty, Indranil, Solans-Monfort, Xavier, Bukhryakov, Konstantin V

“…V imido alkylidenes have been applied for the ring-opening metathesis polymerization involving cyclic olefins. However, those complexes found limited…”
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Synthesis, Antiviral Potency, in Vitro ADMET, and X‑ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV‑1 gp120 by Curreli, Francesca, Kwon, Young Do, Belov, Dmitry S, Ramesh, Ranjith R, Kurkin, Alexander V, Altieri, Andrea, Kwong, Peter D, Debnath, Asim K

“…In our attempt to optimize the lead HIV-1 entry antagonist, NBD-11021, we present in this study the rational design and synthesis of 60 new analogues and…”
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Preclinical Optimization of gp120 Entry Antagonists as anti-HIV‑1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation by Curreli, Francesca, Ahmed, Shahad, Benedict Victor, Sofia M, Iusupov, Ildar R, Belov, Dmitry S, Markov, Pavel O, Kurkin, Alexander V, Altieri, Andrea, Debnath, Asim K

“…We previously reported a milestone in the optimization of NBD-11021, an HIV-1 gp120 antagonist, by developing a new and novel analogue, NBD-14189 (Ref1), which…”
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Mononuclear Four-Coordinate Bis-Fluoride Bis-NHC Complexes of Chromium(II), Iron(II), and Cobalt(II) by Acosta, Carlos M., Belov, Dmitry S., Lamur, Andy H., Brantley, ChristiAnna L., Solans-Monfort, Xavier, Rue, Kelly L., Christou, George, Bukhryakov, Konstantin V.

“…The reaction between silylamido complexes of Cr­(II), Fe­(II), and Co­(II) and IMes·2HF salt in the presence of IMes (IMes = 1,3-dimesitylimidazol-2-ylidene)…”
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Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120 by Curreli, Francesca, Belov, Dmitry S., Kwon, Young Do, Ramesh, Ranjith, Furimsky, Anna M., O'Loughlin, Kathleen, Byrge, Patricia C., Iyer, Lalitha V., Mirsalis, Jon C., Kurkin, Alexander V., Altieri, Andrea, Debnath, Asim K.

“…We are continuing our concerted effort to optimize our first lead entry antagonist, NBD-11021, which targets the Phe43 cavity of the HIV-1 envelope…”
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Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV‑1 Activity by Curreli, Francesca, Kwon, Young Do, Zhang, Hongtao, Scacalossi, Daniel, Belov, Dmitry S., Tikhonov, Artur A., Andreev, Ivan A., Altieri, Andrea, Kurkin, Alexander V., Kwong, Peter D., Debnath, Asim K.

“…Earlier we reported the discovery and design of NBD-556 and their analogs which demonstrated their potential as HIV-1 entry inhibitors. However, progress in…”
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Design, synthesis, and antiviral activity of a series of CD4-mimetic small-molecule HIV-1 entry inhibitors by Curreli, Francesca, Ahmed, Shahad, Benedict Victor, Sofia M., Iusupov, Ildar R., Spiridonov, Evgeny A., Belov, Dmitry S., Altieri, Andrea, Kurkin, Alexander V., Debnath, Asim K.

“…[Display omitted] We presented our continuing stride to optimize the second-generation NBD entry antagonist targeted to the Phe43 cavity of HIV-1 gp120. We…”
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Design of gp120 HIV-1 entry inhibitors by scaffold hopping via isosteric replacements by Iusupov, Ildar R., Curreli, Francesca, Spiridonov, Evgeniy A., Markov, Pavel O., Ahmed, Shahad, Belov, Dmitry S., Manasova, Ekaterina V., Altieri, Andrea, Kurkin, Alexander V., Debnath, Asim K.

“…We present the development of alternative scaffolds and validation of their synthetic pathways as a tool for the exploration of new HIV gp120 inhibitors based…”
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Synthesis, Antiviral Activity, and Structure–Activity Relationship of 1,3‐Benzodioxolyl Pyrrole‐Based Entry Inhibitors Targeting the Phe43 Cavity in HIV‐1 gp120 by Curreli, Francesca, Belov, Dmitry S., Ahmed, Shahad, Ramesh, Ranjith R., Kurkin, Alexander V., Altieri, Andrea, Debnath, Asim K.

“…The pathway by which HIV‐1 enters host cells is a prime target for novel drug discovery because of its critical role in the life cycle of HIV‐1. The HIV‐1…”
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Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold by Andreev, Ivan A., Manvar, Dinesh, Barreca, Maria Letizia, Belov, Dmitry S., Basu, Amartya, Sweeney, Noreena L., Ratmanova, Nina K., Lukyanenko, Evgeny R., Manfroni, Giuseppe, Cecchetti, Violetta, Frick, David N., Altieri, Andrea, Kaushik-Basu, Neerja, Kurkin, Alexander V.

“…Although all-oral direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) treatment is now a reality, today's HCV drugs are expensive, and more…”
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