Dopamine Receptors and TAAR1 Functional Interaction Patterns in the Duodenum Are Impaired in Gastrointestinal Disorders

Dopamine Receptors and TAAR1 Functional Interaction Patterns in the Duodenum Are Impaired in Gastrointestinal Disorders

Currently, there is a growing amount of evidence for the involvement of dopamine receptors and the functionally related trace amine-associated receptor, TAAR1, in upper intestinal function. In the present study, we analyzed their expression in the duodenum using publicly accessible transcriptomic da...

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Bibliographic Details
Published in:Biomedicines Vol. 12; no. 7; p. 1590
Main Authors: Vaganova, Anastasia N, Markina, Alisa A, Belousov, Aleksandr M, Lenskaia, Karina V, Gainetdinov, Raul R
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 17-07-2024
Subjects:
Antiemetics
Datasets
Diabetes mellitus
diabetic gastroparesis
Dopamine
Dopamine D1 receptors
Dopamine D2 receptors
Dopamine D4 receptors
Dopamine D5 receptors
DRD2
DRD4
DRD5
Duodenum
Dyspepsia
Enteric nervous system
functional dyspepsia
Gastrointestinal diseases
Gene expression
Ligands
Localization
Neurons
Permeability
Receptor mechanisms
Semantics
Small intestine
Statistical analysis
TAAR1
Transcriptomics
diabetic gastroparesis
functional dyspepsia
DRD2
trace amines
TAAR1
dopamine
DRD4
duodenum
DRD5
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Summary:Currently, there is a growing amount of evidence for the involvement of dopamine receptors and the functionally related trace amine-associated receptor, TAAR1, in upper intestinal function. In the present study, we analyzed their expression in the duodenum using publicly accessible transcriptomic data. We revealed the expression of , , , , and genes in different available datasets. The results of the gene ontology (GO) enrichment analysis for and especially co-expressed genes were consistent with the previously described localization of D2 and TAAR1 in enteric neurons and secretory cells, respectively. Considering that co-expressed genes are more likely to be involved in the same biological processes, we analyzed genes that are co-expressed with , , , and genes in healthy mucosa and duodenal samples from patients with functional dyspepsia (FD) or diabetes-associated gastrointestinal symptoms. Both pathological conditions showed a deregulation of co-expression patterns, with a high discrepancy between s and co-expressed gene sets in normal tissues and patients' samples and a loss of these genes' functional similarity. Meanwhile, we discovered specific changes in co-expression patterns that may suggest the involvement of TAAR1 and D5 receptors in pathologic or compensatory processes in FD or diabetes accordingly. Despite our findings suggesting the possible role of TAAR1 and dopamine receptors in functional diseases of the upper intestine, underlying mechanisms need experimental exploration and validation.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12071590