Search Results - "Belotti, Daniela"

MesenchymAl stromal cells for Traumatic bRain Injury (MATRIx): a study protocol for a multicenter, double-blind, randomised, placebo-controlled phase II trial by Zanier, Elisa R., Pischiutta, Francesca, Rulli, Eliana, Vargiolu, Alessia, Elli, Francesca, Gritti, Paolo, Gaipa, Giuseppe, Belotti, Daniela, Basso, Gianpaolo, Zoerle, Tommaso, Stocchetti, Nino, Citerio, Giuseppe

“…Background Traumatic brain injury (TBI) is a significant cause of death and disability, with no effective neuroprotective drugs currently available for its…”
Get full text

Rituximab as pre-emptive treatment in patients with thrombotic thrombocytopenic purpura and evidence of anti-ADAMTS13 autoantibodies by Bresin, Elena, Gastoldi, Sara, Daina, Erica, Belotti, Daniela, Pogliani, Enrico, Perseghin, Paolo, Scalzulli, Potito R, Paolini, Rossella, Marcenò, Raimondo, Remuzzi, Giuseppe, Galbusera, Miriam

“…Thrombotic thrombocytopenic purpura (TTP) is a rare and severe disease characterized by thrombocytopenia, microangiopathic haemolytic anemia, neurological and…”
Get more information

Linking cell function with perfusion: insights from the transcatheter delivery of bone marrow-derived CD133 + cells in ischemic refractory cardiomyopathy trial (RECARDIO) by Bassetti, Beatrice, Carbucicchio, Corrado, Catto, Valentina, Gambini, Elisa, Rurali, Erica, Bestetti, Alberto, Gaipa, Giuseppe, Belotti, Daniela, Celeste, Fabrizio, Parma, Matteo, Righetti, Stefano, Biava, Lorenza, Arosio, Maurizio, Bonomi, Alice, Agostoni, Piergiuseppe, Scacciatella, Paolo, Achilli, Felice, Pompilio, Giulio

“…Cell therapy with bone marrow (BM)-derived progenitors has emerged as a promising therapeutic for refractory angina (RA) patients. In the present study, we…”
Get full text

Complement activation: the missing link between ADAMTS-13 deficiency and microvascular thrombosis of thrombotic microangiopathies by Ruiz-Torres, Maria Piedad, Casiraghi, Federica, Galbusera, Miriam, Macconi, Daniela, Gastoldi, Sara, Todeschini, Marta, Porrati, Francesca, Belotti, Daniela, Pogliani, Enrico Maria, Noris, Marina, Remuzzi, Giuseppe

“…Endothelial injury is the central factor in the events leading to thrombotic microangiopathy (TMA); however, the mechanisms involved are not fully understood…”
Get more information

Inhibition of the ABL Kinase Activity Blocks the Proliferation of BCR/ABL+Leukemic Cells and Induces Apoptosis by Gambacorti-Passerini, Carlo, le Coutre, Philipp, Mologni, Luca, Fanelli, Mirco, Bertazzoli, Carla, Marchesi, Edoardo, Di Nicola, Massimo, Biondi, Andrea, Corneo, Gian Marco, Belotti, Daniela, Pogliani, Enrico, Lydon, Nicholas B.

“…The BCR/ABL fusion protein transforms myeloid stem cells. Both chronic myelogenous leukemias (CML) and a subset of acute lymphoblastic leukemias (ALL) are…”
Get full text

Sleeping Beauty-engineered CAR T cells achieve antileukemic activity without severe toxicities by Magnani, Chiara F, Gaipa, Giuseppe, Lussana, Federico, Belotti, Daniela, Gritti, Giuseppe, Napolitano, Sara, Matera, Giada, Cabiati, Benedetta, Buracchi, Chiara, Borleri, Gianmaria, Fazio, Grazia, Zaninelli, Silvia, Tettamanti, Sarah, Cesana, Stefania, Colombo, Valentina, Quaroni, Michele, Cazzaniga, Giovanni, Rovelli, Attilio, Biagi, Ettore, Galimberti, Stefania, Calabria, Andrea, Benedicenti, Fabrizio, Montini, Eugenio, Ferrari, Silvia, Introna, Martino, Balduzzi, Adriana, Valsecchi, Maria Grazia, Dastoli, Giuseppe, Rambaldi, Alessandro, Biondi, Andrea

“…BACKGROUNDChimeric antigen receptor (CAR) T cell immunotherapy has resulted in complete remission (CR) and durable response in highly refractory patients…”
Get full text

Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study by Genchi, Angela, Brambilla, Elena, Sangalli, Francesca, Radaelli, Marta, Bacigaluppi, Marco, Furlan, Roberto, Andolfo, Annapaola, Drago, Denise, Magagnotti, Cinzia, Scotti, Giulia Maria, Greco, Raffaella, Vezzulli, Paolo, Ottoboni, Linda, Bonopane, Marco, Capilupo, Daniela, Ruffini, Francesca, Belotti, Daniela, Cabiati, Benedetta, Cesana, Stefania, Matera, Giada, Leocani, Letizia, Martinelli, Vittorio, Moiola, Lucia, Vago, Luca, Panina-Bordignon, Paola, Falini, Andrea, Ciceri, Fabio, Uglietti, Anna, Sormani, Maria Pia, Comi, Giancarlo, Battaglia, Mario Alberto, Rocca, Maria A., Storelli, Loredana, Pagani, Elisabetta, Gaipa, Giuseppe, Martino, Gianvito

“…Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represent an unmet…”
Get full text

A comprehensive report of long-term stability data for a range ATMPs: A need to develop guidelines for safe and harmonized stability studies by Capelli, Chiara, Frigerio, Simona, Lisini, Daniela, Nava, Sara, Gaipa, Giuseppe, Belotti, Daniela, Cabiati, Benedetta, Budelli, Silvia, Lazzari, Lorenza, Bagnarino, Jessica, Tanzi, Matteo, Comoli, Patrizia, Perico, Norberto, Introna, Martino, Golay, Josée

“…Advanced therapy medicinal products (ATMPs) are novel drugs based on genes, cells or tissues developed to treat many different diseases. Stability studies of…”
Get full text

Final Results of Phase I/II Study of Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with B-Cell Acute Lymphoblastic Leukemia Relapsed Post-HSCT by Lussana, Federico, Magnani, Chiara Francesca, Gaipa, Giuseppe, Galimberti, Stefania, Gritti, Giuseppe, Belotti, Daniela, Napolitano, Sara, Buracchi, Chiara, Borleri, Gian Maria, Rambaldi, Benedetta, Rizzuto, Giuliana, Grassi, Anna, Paganessi, Muriel, Ferrari, Silvia, Tettamanti, Sarah, Gazzaniga, Giovanni, Capelli, Chiara, Gotti, Elisa, Introna, Martino, Balduzzi, Adriana, Valsecchi, Maria Grazia, Dastoli, Giuseppe, Rambaldi, Alessandro, Biondi, Andrea

Get full text

Carcik-CD19 Cells Expand In Vivo Toward a CD8+ Memory Phenotype and Their Persistence Is Associated with a Longer Duration of Response by Rambaldi, Benedetta, Galimberti, Stefania, Rizzuto, Giuliana, Magnani, Chiara Francesca, Buracchi, Chiara, Risca, Giulia, Paredi, Martina, Belotti, Daniela, Moretti, Alex, Ponzo, Marianna, Tettamanti, Sarah, Borleri, Gian Maria, Meli, Cristian, Paganessi, Muriel, Zaninelli, Silvia, Gotti, Elisa, Capelli, Chiara, Introna, Martino, Lussana, Federico, Gritti, Giuseppe, Ferrari, Silvia, Grassi, Anna, Napolitano, Sara, Balduzzi, Adriana, Valsecchi, Maria Grazia, Dastoli, Giuseppe, Rambaldi, Alessandro, Biondi, Andrea, Gaipa, Giuseppe

Get full text

Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with Acute Lymphoblastic Leukemia Relapsed Post-HSCT by Magnani, Chiara F, Gaipa, Giuseppe, Lussana, Federico, Gritti, Giuseppe, Belotti, Daniela, Napolitano, Sara, Buracchi, Chiara, Borleri, Gian Maria, Rambaldi, Benedetta, Zaninelli, Silvia, Rizzuto, Giuliana, Cavallaro, Gianluca, Tettamanti, Sarah, Cazzaniga, Giovanni, Galimberti, Stefania, Ferrari, Silvia, Introna, Martino, Balduzzi, Adriana, Valsecchi, Maria Grazia, Dastoli, Giuseppe, Rambaldi, Alessandro, Biondi, Andrea

“…Introduction Allogeneic Chimeric Antigen Receptor (CAR) T cells engineered with non-viral methods offer a modality to reduce costs and logistical complexity of…”
Get full text

Donor-Derived CAR T Cells Engineered with Sleeping Beauty Achieve Anti-Leukemic Activity without Severe Toxicity by Magnani, Chiara F, Gaipa, Giuseppe, Lussana, Federico, Belotti, Daniela, Gritti, Giuseppe, Napolitano, Sara, Buracchi, Chiara, Borleri, Gian Maria, Zaninelli, Silvia, Rizzuto, Giuliana, Tettamanti, Sarah, Colombo, Valentina, Cazzaniga, Giovanni, Cabiati, Benedetta, Rovelli, Attilio, Biagi, Ettore, Galimberti, Stefania, Benedicenti, Fabrizio, Montini, Eugenio, Ferrari, Silvia, Introna, Martino, Balduzzi, Adriana, Valsecchi, Maria Grazia, Dastoli, Giuseppe, Rambaldi, Alessandro, Biondi, Andrea

“…Background Significant efforts over the past few years led Chimeric Antigen Receptor (CAR) T cell therapy to success in relapsed and refractory (r/r) B-cell…”
Get full text

Donor-Derived CD19 CAR Cytokine Induced Killer (CIK) Cells Engineered with Sleeping Beauty Transposon for Relapsed B-Cell Acute Lymphoblastic Leukemia (B-ALL) by Magnani, Chiara F, Gaipa, Giuseppe, Belotti, Daniela, Matera, Giada, Tettamanti, Sarah, Cabiati, Benedetta, Buracchi, Chiara, Fazio, Grazia, Zaninelli, Silvia, Rigamonti, Silvia, Cesana, Stefania, Colombo, Valentina, Cazzaniga, Giovanni, Rovelli, Attilio, Balduzzi, Adriana, Napolitano, Sara, Benedicenti, Fabrizio, Montini, Eugenio, Borleri, Gian Maria, Ferrari, Silvia, Gritti, Giuseppe, Lussana, Federico, Introna, Martino, Rambaldi, Alessandro, Dastoli, Giuseppe, Biondi, Andrea

“…▪ Background Immunotherapy using patient-derived CAR T cells has achieved complete remission and durable response in highly refractory populations. However,…”
Get full text

Clinical-Grade Transduction of Allogeneic Cytokine Induced Killer (CIK) Cells with CD19 Chimeric Antigen Receptor (CAR) Using Sleeping Beauty (SB) Transposon: Successful GMP-Compliant Manufacturing for Clinical Applications by Gaipa, Giuseppe, Magnani, Chiara Francesca, Belotti, Daniela, Matera, Giada, Tettamanti, Sarah, Cabiati, Benedetta, Cesana, Stefania, Colombo, Valentina, Cazzaniga, Giovanni, Fazio, Grazia, Buracchi, Chiara, Rigamonti, Silvia, Rovelli, Attilio, Balduzzi, Adriana, Napolitano, Sara, Montini, Eugenio, Borleri, Gian Maria, Gritti, Giuseppe, Lussana, Federico, Introna, Martino, Rambaldi, Alessandro, Dastoli, Giuseppe, Biondi, Andrea

“…Background: Acute lymphoblastic leukemia (ALL) is a malignant disorder with a long-term remission of less than 50% of adult patients and of nearly 80% of…”
Get full text

Full GMP-Compliant Validation of Bone Marrow-Derived Human CD133+ Cells as Advanced Therapy Medicinal Product for Refractory Ischemic Cardiomyopathy by Gambini, Elisa, Pompilio, Giulio, Cavallotti, Laura, Parma, Matteo, Biagi, Ettore, Spaltro, Gabriella, Cabiati, Benedetta, Bassetti, Beatrice, Gaipa, Giuseppe, Belotti, Daniela, Biondi, A.

“…According to the European Medicine Agency (EMA) regulatory frameworks, Advanced Therapy Medicinal Products (ATMP) represent a new category of drugs in which…”
Get full text

Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients by Introna, Martino, Lucchini, Giovanna, Dander, Erica, Galimberti, Stefania, Rovelli, Attilio, Balduzzi, Adriana, Longoni, Daniela, Pavan, Fabio, Masciocchi, Francesca, Algarotti, Alessandra, Micò, Caterina, Grassi, Anna, Deola, Sara, Cavattoni, Irene, Gaipa, Giuseppe, Belotti, Daniela, Perseghin, Paolo, Parma, Matteo, Pogliani, Enrico, Golay, Josee, Pedrini, Olga, Capelli, Chiara, Cortelazzo, Sergio, D’Amico, Giovanna, Biondi, Andrea, Rambaldi, Alessandro, Biagi, Ettore

“…Abstract This phase I multicenter study was aimed at assessing the feasibility and safety of intravenous administration of third party bone marrow–derived…”
Get full text

Full GMP-compliant validation of bone marrow-derived human [CD133.sup.+] cells as advanced therapy medicinal product for refractory ischemic cardiomyopathy by Belotti, Daniela, Gaipa, Giuseppe, Bassetti, Beatrice, Cabiati, Benedetta, Spaltro, Gabriella, Biagi, Ettore, Parma, Matteo, Biondi, Andrea, Cavallotti, Laura, Gambini, Elisa, Pompilio, Giulio

Get full text

Phase II Study of Sequential Infusion of Donor Lymphocyte Infusion and Cytokine-Induced Killer Cells for Patients Relapsed after Allogeneic Hematopoietic Stem Cell Transplantation by Introna, Martino, Lussana, Federico, Algarotti, Alessandra, Gotti, Elisa, Valgardsdottir, Rut, Micò, Caterina, Grassi, Anna, Pavoni, Chiara, Ferrari, Maria Luisa, Delaini, Federica, Todisco, Elisabetta, Cavattoni, Irene, Deola, Sara, Biagi, Ettore, Balduzzi, Adriana, Rovelli, Attilio, Parma, Matteo, Napolitano, Sara, Sgroi, Giusy, Marrocco, Emanuela, Perseghin, Paolo, Belotti, Daniela, Cabiati, Benedetta, Gaipa, Giuseppe, Golay, Josée, Biondi, Andrea, Rambaldi, Alessandro

“…Seventy-four patients who relapsed after allogeneic stem cell transplantation were enrolled in a phase IIA study and treated with the sequential infusion of…”
Get full text

GMP‐based CD133+ cells isolation maintains progenitor angiogenic properties and enhances standardization in cardiovascular cell therapy by Gaipa, Giuseppe, Tilenni, Manuela, Straino, Stefania, Burba, Ilaria, Zaccagnini, Germana, Belotti, Daniela, Biagi, Ettore, Valentini, Marco, Perseghin, Paolo, Parma, Matteo, Campli, Cristiana Di, Biondi, Andrea, Capogrossi, Maurizio C., Pompilio, Giulio, Pesce, Maurizio

“…The aim of the present study was to develop and validate a good manufacturing practice (GMP) compliant procedure for the preparation of bone marrow (BM)…”
Get full text

Rituximab prevents recurrence of thrombotic thrombocytopenic purpura: a case report by Galbusera, Miriam, Bresin, Elena, Noris, Marina, Gastoldi, Sara, Belotti, Daniela, Capoferri, Cristina, Daina, Erica, Perseghin, Paolo, Scheiflinger, Friedrich, Fakhouri, Fadi, Grünfeld, Jean-Pierre, Pogliani, Enrico, Remuzzi, Giuseppe

“…Thrombotic thrombocytopenic purpura (TT666666) is a rare disorder of small vessels that is associated with deficiency of the von Willebrand factor–cleaving…”
Get full text