Search Results - "Belo, Jose Antonio"

CCBE1 Is Essential for Epicardial Function during Myocardium Development by Bonet, Fernando, Añez, Sabrina Brito, Inácio, José Manuel, Futschik, Matthias E., Belo, José Antonio

“…The epicardium is a single cell layer of mesothelial cells that plays a critical role during heart development contributing to different cardiac cell types of…”
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Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development by Facucho-Oliveira, João, Bento, Margaret, Belo, José-António

“…The mammalian heart is a complex organ composed of diverse components and various cell types. Heart organogenesis requires the contribution of distinct pools…”
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Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2 by Yoshiba, Satoko, Shiratori, Hidetaka, Kuo, Ivana Y., Kawasumi, Aiko, Shinohara, Kyosuke, Nonaka, Shigenori, Asai, Yasuko, Sasaki, Genta, Belo, Jose Antonio, Sasaki, Hiroshi, Nakai, Junichi, Dworniczak, Bernd, Ehrlich, Barbara E., Pennekamp, Petra, Hamada, Hiroshi

“…Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is…”
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Developmental expression of Shisa-2 in Xenopus laevis by Silva, Ana-Cristina, Filipe, Mário, Vitorino, Marta, Steinbeisser, Herbert, Belo, José-António

“…Shisa is an antagonist of Wnt and FGF signaling, that functions cell autonomously in the endoplasmic reticulum (ER) to inhibit the post-translational…”
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Fluid flow and interlinked feedback loops establish left–right asymmetric decay of Cerl2 mRNA by Nakamura, Tetsuya, Saito, Daisuke, Kawasumi, Aiko, Shinohara, Kyosuke, Asai, Yasuko, Takaoka, Katsuyoshi, Dong, Fenglan, Takamatsu, Atsuko, Belo, Jose Antonio, Mochizuki, Atsushi, Hamada, Hiroshi

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Cripto-independent Nodal signaling promotes positioning of the A–P axis in the early mouse embryo by Liguori, Giovanna L., Borges, Ana Cristina, D'Andrea, Daniela, Liguoro, Annamaria, Gonçalves, Lisa, Salgueiro, Ana Marisa, Persico, M. Graziella, Belo, José Antonio

“…During early mouse development, the TGFβ-related protein Nodal specifies the organizing centers that control the formation of the anterior–posterior (A–P)…”
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N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase expression during early mouse embryonic development by Salgueiro, Ana-Marisa, Filipe, Mario, Belo, Jose-Antonio

“…N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is an enzyme which is known to help build up the GlcAbeta1-3GalNAc(4,6-bisSO4) unit of…”
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miRNAs in Heart Development and Disease by Lozano-Velasco, Estefania, Inácio, José Manuel, Sousa, Inês, Guimarães, Ana Rita, Franco, Diego, Moura, Gabriela, Belo, José António

“…Cardiovascular diseases (CVD) are a group of disorders that affect the heart and blood vessels. They include conditions such as myocardial infarction, coronary…”
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The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis by Marques, Sara, Borges, Ana Cristina, Silva, Ana Cristina, Freitas, Sandra, Cordenonsi, Michelangelo, Belo, José António

“…Correct establishment of the left/right (L/R) body asymmetry in the mouse embryo requires asymmetric activation of the evolutionarily conserved Nodal signaling…”
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Xenopus Pkdcc1 and Pkdcc2 Are Two New Tyrosine Kinases Involved in the Regulation of JNK Dependent Wnt/PCP Signaling Pathway by Vitorino, Marta, Silva, Ana Cristina, Inácio, José Manuel, Ramalho, José Silva, Gur, Michal, Fainsod, Abraham, Steinbeisser, Herbert, Belo, José António

“…Protein Kinase Domain Containing, Cytoplasmic (PKDCC) is a protein kinase which has been implicated in longitudinal bone growth through regulation of…”
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Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells by Bover, Oriol, Justo, Tiago, Pereira, Paulo N G, Facucho-Oliveira, João, Inácio, José M, Ramalho, José S, Domian, Ibrahim J, Belo, José António

“…Understanding the molecular pathways regulating cardiogenesis is crucial for the early diagnosis of heart diseases and improvement of cardiovascular disease…”
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Targeted inactivation of Cerberus like-2 leads to left ventricular cardiac hyperplasia and systolic dysfunction in the mouse by Araújo, Ana Carolina, Marques, Sara, Belo, José António

“…Previous analysis of the Cerberus like 2 knockout (Cerl2-/-) mouse revealed a significant mortality during the first day after birth, mostly due to cardiac…”
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Left–right asymmetry in the level of active Nodal protein produced in the node is translated into left–right asymmetry in the lateral plate of mouse embryos by Kawasumi, Aiko, Nakamura, Tetsuya, Iwai, Naomi, Yashiro, Kenta, Saijoh, Yukio, Belo, Jose Antonio, Shiratori, Hidetaka, Hamada, Hiroshi

“…Left–right (L–R) asymmetry in the mouse embryo is generated in the node and is dependent on cilia-driven fluid flow, but how the initial asymmetry is…”
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The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node by Inácio, José Manuel, Marques, Sara, Nakamura, Tetsuya, Shinohara, Kyosuke, Meno, Chikara, Hamada, Hiroshi, Belo, José António

“…The determination of left-right body asymmetry in mouse embryos depends on the interplay of molecules in a highly sensitive structure, the node. Here, we show…”
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Myocardial RNA Sequencing Reveals New Potential Therapeutic Targets in Heart Failure with Preserved Ejection Fraction by Inácio, José M, Cristo, Fernando, Pinheiro, Miguel, Vasques-Nóvoa, Francisco, Saraiva, Francisca, Nunes, Mafalda M, Rosas, Graça, Reis, Andreia, Coimbra, Rita, Oliveira, José Luís, Moura, Gabriela, Leite-Moreira, Adelino, Belo, José António

“…Heart failure with preserved ejection fraction (HFpEF) represents a global health challenge, with limited therapies proven to enhance patient outcomes. This…”
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Expression and function of Ccbe1 in the chick early cardiogenic regions are required for correct heart development by Furtado, João, Bento, Margaret, Correia, Elizabeth, Inácio, José Manuel, Belo, José António

“…During the course of a differential screen to identify transcripts specific for chick heart/hemangioblast precursor cells, we have identified Ccbe1 (Collagen…”
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Fluid flow and interlinked feedback loops establish left–right asymmetric decay of Cerl2 mRNA by Nakamura, Tetsuya, Saito, Daisuke, Kawasumi, Aiko, Shinohara, Kyosuke, Asai, Yasuko, Takaoka, Katsuyoshi, Dong, Fenglan, Takamatsu, Atsuko, Belo, Jose Antonio, Mochizuki, Atsushi, Hamada, Hiroshi

“…Breaking of left–right symmetry in mouse embryos requires fluid flow at the node, but the precise action of the flow has remained unknown. Here we show that…”
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Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos by Oki, Shinya, Kitajima, Keiko, Marques, Sara, Belo, José António, Yokoyama, Takahiko, Hamada, Hiroshi, Meno, Chikara

“…The node at the anterior tip of the primitive streak serves as an initial generator of the left-right (L-R) axis in mammalian embryos. We now show that a small…”
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DAND5 Inactivation Enhances Cardiac Differentiation in Mouse Embryonic Stem Cells by Inácio, José Manuel, von Gilsa Lopes, João, Silva, Ana Mafalda, Cristo, Fernando, Marques, Sara, Futschik, Matthias E, Belo, José António

“…Deciphering the clues of a regenerative mechanism for the mammalian adult heart would save millions of lives in the near future. Heart failure due to…”
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A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development by Chi, Lijun, Saarela, Ulla, Railo, Antti, Prunskaite-Hyyryläinen, Renata, Skovorodkin, Ilya, Anthony, Shelagh, Katsu, Kenjiro, Liu, Yu, Shan, Jingdong, Salgueiro, Ana Marisa, Belo, José António, Davies, Jamie, Yokouchi, Yuji, Vainio, Seppo J

“…The epithelial ureteric bud is critical for mammalian kidney development as it generates the ureter and the collecting duct system that induces nephrogenesis…”
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