Search Results - "Belmonte, Kristen"

Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction by Fryer, Allison D, Stein, Louis H, Nie, Zhenying, Curtis, Damian E, Evans, Christopher M, Hodgson, Simon T, Jose, Peter J, Belmonte, Kristen E, Fitch, Erin, Jacoby, David B

“…Eosinophils cluster around airway nerves in patients with fatal asthma and in antigen-challenged animals. Activated eosinophils release major basic protein,…”
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Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1 by Waters, Catherine M, Long, Jaclyn, Gorshkova, Irina, Fujiwara, Yuko, Connell, Michelle, Belmonte, Kristen E, Tigyi, Gabor, Natarajan, Viswanathan, Pyne, Susan, Pyne, Nigel J

“…We have previously identified a novel complex between the platelet‐derived growth factor (PDGF)? receptor and the sphingosine 1‐phosphate receptor‐1 (S1P1)…”
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Neutrophil Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors in Pneumonia by Rahaman, Matiur, Costello, Richard W, Belmonte, Kristen E, Gendy, Samir S, Walsh, Marie-Therese

“…The phospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via transmembrane receptors S1P 1-5 and LPA 1-3, respectively. Both have…”
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Regulation of TNF‐α and IFN‐γ induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease by Hardaker, Elizabeth L., Bacon, Alicia M., Carlson, Karey, Roshak, Amy K., Foley, James J., Schmidt, Dulcie B., Buckley, Peter T., Comegys, Meghan, Panettieri, Reynold A., Sarau, Henry M., Belmonte, Kristen E.

“…ABSTRACT The chemokine CXCL10 is produced by many inflammatory cells found in the diseased lung and has been implicated in the pathogenesis of chronic…”
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Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups by Jin, Qi, Davis, Roderick S., Bullion, Ann M., Jin, Jian, Wang, Yonghui, Widdowson, Katherine L., Palovich, Michael R., Foley, James J., Schmidt, Dulcie B., Buckley, Peter T., Webb, Edward F., Salmon, Michael, Belmonte, Kristen E., Sarau, Henry M., Busch-Petersen, Jakob

“…Novel tyrosine-based, long-acting inhaled muscarinic antagonists: preparation, SAR and biological evaluation. Tyrosine ureas had been identified as potent…”
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Fluorescent styryl dyes FM1-43 and FM2-10 are muscarinic receptor antagonists: intravital visualization of receptor occupancy by Mazzone, Stuart B., Mori, Nanako, Burman, Miriam, Palovich, Michael, Belmonte, Kristen E., Canning, Brendan J.

“…The fluorescent styryl dyes FM1-43 and FM2-10 have been used to visualize the endocytic and exocytic processes involved in neurotransmission in a variety of…”
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Discovery of Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists by Jin, Jian, Wang, Yonghui, Shi, Dongchuan, Wang, Feng, Davis, Roderick S, Jin, Qi, Fu, Wei, Foley, James J, Webb, Edward F, Dehaas, Chris J, Berlanga, Manuela, Burman, Miriam, Sarau, Henry M, Morrow, Dwight M, Rao, Parvathi, Kallal, Lorena A, Moore, Michael L, Rivero, Ralph A, Palovich, Michael, Salmon, Michael, Belmonte, Kristen E, Busch-Petersen, Jakob

“…High throughput screening and subsequent optimization led to the discovery of novel quaternary ammonium salts as highly potent muscarinic acetylcholine…”
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Discovery of Biphenyl Piperazines as Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists by Jin, Jian, Budzik, Brian, Wang, Yonghui, Shi, Dongchuan, Wang, Feng, Xie, Haibo, Wan, Zehong, Zhu, Chongye, Foley, James J, Webb, Edward F, Berlanga, Manuela, Burman, Miriam, Sarau, Henry M, Morrow, Dwight M, Moore, Michael L, Rivero, Ralph A, Palovich, Michael, Salmon, Michael, Belmonte, Kristen E, Lainé, Dramane I

“…A series of novel biphenyl piperazines was discovered as highly potent muscarinic acetylcholine receptor antagonists via high throughput screening and…”
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Discovery of (3- endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD by Wan, Zehong, Laine, Dramane I., Yan, Hongxing, Zhu, Chongjie, Widdowson, Katherine L., Buckley, Peter T., Burman, Miriam, Foley, James J., Sarau, Henry M., Schmidt, Dulcie B., Webb, Edward F., Belmonte, Kristen E., Palovich, Michael

“…Design and syntheses of a novel series of muscarinic antagonists are reported. These efforts have culminated in the discovery of (3-…”
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M3 muscarinic acetylcholine receptor antagonists : SAR and optimization of bi-aryl amines by BUDZIK, Brian, YONGHUI WANG, SARAU, Henry M, MORROW, Dwight M, MOORE, Michael L, RIVERO, Ralph A, PALOVICH, Michael, SALMON, Michael, BELMONTE, Kristen E, LAINE, Dramane I, JIAN JIN, DONGCHUAN SHI, FENG WANG, HAIBO XIE, ZEHONG WAN, CHONGYE ZHU, FOLEY, James J, NUTHULAGANTI, Parvathi, KALLAL, Lorena A

“…Exploration of multiple regions of a bi-aryl amine template led to the identification of highly potent M(3) muscarinic acetylcholine receptor antagonists such…”
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Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists by Lainé, Dramane I., Xie, Haibo, Buffet, Noémie, Foley, James J., Buckley, Peter, Webb, Edward F., Widdowson, Katherine L., Palovich, Michael R., Belmonte, Kristen E.

“…In the course of our research program to develop novel muscarinic receptor antagonists for the treatment of COPD, new tropane carbamate derivatives were…”
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Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas by Jin, Jian, Wang, Yonghui, Shi, Dongchuan, Wang, Feng, Fu, Wei, Davis, Roderick S., Jin, Qi, Foley, James J., Sarau, Henry M., Morrow, Dwight M., Moore, Michael L., Rivero, Ralph A., Palovich, Michael, Salmon, Michael, Belmonte, Kristen E., Busch-Petersen, Jakob

“…SAR exploration of multiple regions of a tyrosine urea template led to the identification of very potent muscarinic acetylcholine receptor antagonists such as…”
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Oxazolidinones as novel human CCR8 antagonists by Jin, Jian, Wang, Yonghui, Wang, Feng, Kerns, Jeffery K., Vinader, Victoria M., Hancock, Ashley P., Lindon, Matthew J., Stevenson, Graeme I., Morrow, Dwight M., Rao, Parvathi, Nguyen, Cuc, Barrett, Victoria J., Browning, Chris, Hartmann, Guido, Andrew, David P., Sarau, Henry M., Foley, James J., Jurewicz, Anthony J., Fornwald, James A., Harker, Andy J., Moore, Michael L., Rivero, Ralph A., Belmonte, Kristen E., Connor, Helen E.

“…High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human…”
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Antigen-induced hyperreactivity to histamine: role of the vagus nerves and eosinophils by Costello, R W, Evans, C M, Yost, B L, Belmonte, K E, Gleich, G J, Jacoby, D B, Fryer, A D

“…M2 muscarinic receptors limit acetylcholine release from the pulmonary parasympathetic nerves. M2 receptors are dysfunctional in antigen-challenged guinea…”
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Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease by Belmonte, Kristen E

“…Abundant data from animal models and humans support the hypothesis that changes at the level of parasympathetic neuronal control of airway smooth muscle result…”
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Developmental Expression of Muscarinic Acetylcholine Receptors in Chick Retina: Selective Induction of M2 Muscarinic Receptor Expression In Ovo by a Factor Secreted by Muller Glial Cells by Belmonte, Kristen E, McKinnon, Lise A, Nathanson, Neil M

“…Muscarinic acetylcholine receptors (mAChRs) play an important role in signal processing in the retina. We have used subtype-specific antibodies to identify the…”
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Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs by Belmonte, Kristen E, Jacoby, David B, Fryer, Allison D

“…The function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs was investigated. Neuronal M2 muscarinic receptors inhibit acetylcholine…”
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Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea‐pigs by Costello, Richard W, Fryer, Allison D, Belmonte, Kristen E, Jacoby, David B

“…The role of tachykinin NK1 receptors in the recruitment of eosinophils to airway nerves, loss of inhibitory neuronal M2 muscarinic receptor function and the…”
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Increased function of inhibitory neuronal M 2 muscarinic receptors in diabetic rat lungs by Belmonte, Kristen E, Jacoby, David B, Fryer, Allison D

“…The function of inhibitory neuronal M 2 muscarinic receptors in diabetic rat lungs was investigated. Neuronal M 2 muscarinic receptors inhibit acetylcholine…”
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Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists by Lainé, Dramane I, McCleland, Brent, Thomas, Sonia, Neipp, Christopher, Underwood, Brian, Dufour, Jeremy, Widdowson, Katherine L, Palovich, Michael R, Blaney, Frank E, Foley, James J, Webb, Edward F, Luttmann, Mark A, Burman, Miriam, Belmonte, Kristen, Salmon, Michael

“…A novel 4-hydroxyl(diphenyl)methyl substituted quinuclidine series was discovered as a very promising class of muscarinic antagonists. The structure−activity…”
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