Search Results - "Belma, Turan"

The role of labile Zn2+ and Zn2+–transporters in the pathophysiology of mitochondria dysfunction in cardiomyocytes by Turan, Belma, Tuncay, Erkan

“…An important energy supplier of cardiomyocytes is mitochondria, similar to other mammalian cells. Studies have demonstrated that any defect in the normal…”
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Role of antioxidants in redox regulation of diabetic cardiovascular complications by Turan, Belma

“…Cardiovascular dysfunction is leading cause for the mortality of diabetic individuals, in part due to a specific cardiomyopathy, and due to altered endothelial…”
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Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts by Durak, Aysegul, Turan, Belma

“…Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular dysfunction via the pleiotropic effects behind their receptor action. However, it is…”
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Impact of Labile Zinc on Heart Function: From Physiology to Pathophysiology by Turan, Belma, Tuncay, Erkan

“…Zinc plays an important role in biological systems as bound and histochemically reactive labile Zn . Although Zn concentration is in the nM range in…”
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A SGLT2 inhibitor dapagliflozin suppresses prolonged ventricular-repolarization through augmentation of mitochondrial function in insulin-resistant metabolic syndrome rats by Durak, Aysegul, Olgar, Yusuf, Degirmenci, Sinan, Akkus, Erman, Tuncay, Erkan, Turan, Belma

“…Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in…”
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A Comparative Summary on Antioxidant-like Actions of Timolol with Other Antioxidants in Diabetic Cardiomyopathy by Turan, Belma

“…Cellular signaling associated with cardiac β-adrenergic receptors (β-AR) is composed of coupled mechanism among β 1-/β2-AR and Gs proteins with contribution of…”
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Correction to: The role of labile Zn2+ and Zn2+–transporters in the pathophysiology of mitochondria dysfunction in cardiomyocytes by Turan, Belma, Tuncay, Erkan

“…Unfortunately, in the original publication of the article, Table 2 was published incorrectly. The correct version of Table 2 is provided in this correction…”
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Cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocyte on hyperglycemic cardiomyocytes through alleviation of oxidative and endoplasmic reticulum stress by Bitirim, Ceylan Verda, Ozer, Zeynep Busra, Aydos, Dunya, Genc, Kardelen, Demirsoy, Seyma, Akcali, Kamil Can, Turan, Belma

“…Extracellular vesicles (EVs) play important roles in diabetes mellitus (DM) via connecting the immune cell response to tissue injury, besides stimulation to…”
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Mitochondria-Targeting Antioxidant Provides Cardioprotection through Regulation of Cytosolic and Mitochondrial Zn2+ Levels with Re-Distribution of Zn2+-Transporters in Aged Rat Cardiomyocytes by Olgar, Yusuf, Tuncay, Erkan, Turan, Belma

“…Aging is an important risk factor for cardiac dysfunction. Heart during aging exhibits a depressed mechanical activity, at least, through…”
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Relationship Between Downregulation of miRNAs and Increase of Oxidative Stress in the Development of Diabetic Cardiac Dysfunction: Junctin as a Target Protein of miR-1 by Yildirim, Samet Serdar, Akman, Duygu, Catalucci, Daniele, Turan, Belma

“…Oxidative stress is involved in the etiology of diabetes-induced cardiac dysfunction while microRNAs (miRNAs) are known as regulators for genes involved in…”
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IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action by Lecour, Sandrine, Andreadou, Ioanna, Bøtker, Hans Erik, Davidson, Sean M., Heusch, Gerd, Ruiz-Meana, Marisol, Schulz, Rainer, Zuurbier, Coert J., Ferdinandy, Péter, Hausenloy, Derek J.

“…Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new…”
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Bimodal Effects of P2Y12 Antagonism on Matrix Metalloproteinase–Associated Contractile Dysfunction in İnsulin-Resistant Mammalian Heart by Olgar, Yusuf, Tuncay, Erkan, Billur, Deniz, Turan, Belma

“…The matrix metalloproteinases (MMPs) contribute to matrix remodeling in diabetes via tissue degradation; however, their contributions can be different…”
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Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart by Tuncay, Erkan, Bitirim, Verda C., Durak, Aysegul, Carrat, Gaelle R.J., Taylor, Kathryn M., Rutter, Guy A., Turan, Belma

“…Changes in cellular free Zn2+ concentration, including those in the sarco(endo)plasmic reticulum [S(E)R], are primarily coordinated by Zn2+ transporters (ZnTs)…”
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Ticagrelor alleviates high-carbohydrate intake induced altered electrical activity of ventricular cardiomyocytes by regulating sarcoplasmic reticulum–mitochondria miscommunication by Olgar, Yusuf, Durak, Aysegul, Degirmenci, Sinan, Tuncay, Erkan, Billur, Deniz, Ozdemir, Semir, Turan, Belma

“…Metabolic syndrome (MetS) is associated with additional cardiovascular risk in mammalians while there are relationships between hyperglycemia-associated…”
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Molecular and Electrophysiological Role of Diabetes-Associated Circulating Inflammatory Factors in Cardiac Arrhythmia Remodeling in a Metabolic-Induced Model of Type 2 Diabetic Rat by Zayas-Arrabal, Julian, Alquiza, Amaia, Tuncay, Erkan, Turan, Belma, Gallego, Monica, Casis, Oscar

“…Background: Diabetic patients have prolonged cardiac repolarization and higher risk of arrhythmia. Besides, diabetes activates the innate immune system,…”
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Titin and CK2α are New Intracellular Targets in Acute Insulin Application-Associated Benefits on Electrophysiological Parameters of Left Ventricular Cardiomyocytes From Insulin-Resistant Metabolic Syndrome Rats by Durak, Aysegul, Bitirim, Ceylan V., Turan, Belma

“…Background Previous studies have demonstrated that a high-carbohydrate intake could induce metabolic syndrome (MetS) in male rats with marked cardiac…”
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Ticagrelor reverses the mitochondrial dysfunction through preventing accumulated autophagosomes-dependent apoptosis and ER stress in insulin-resistant H9c2 myocytes by Olgar, Yusuf, Tuncay, Erkan, Billur, Deniz, Durak, Aysegul, Ozdemir, Semir, Turan, Belma

“…Ticagrelor, a P 2 Y 12 -receptor inhibitor, and a non-thienopyridine agent are used to treat diabetic patients via its effects on off-target mechanisms…”
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Aging related functional and structural changes in the heart and aorta: MitoTEMPO improves aged-cardiovascular performance by Olgar, Yusuf, Degirmenci, Sinan, Durak, Aysegul, Billur, Deniz, Can, Belgin, Kayki-Mutlu, Gizem, Arioglu-Inan E, Ebru, Turan, Belma

“…Aging in humans represents declining in cardio-protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key…”
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Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies by Turan, Belma, Tuncay, Erkan, Vassort, Guy

“…Summary Resveratrol, a natural phytoalexin found in wine has the potential to impact a variety of human diseases. Resveratrol like other polyphenols activates…”
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Interrelated In Vitro Mechanisms of Sibutramine-Induced Cardiotoxicity by Alyu, Feyza, Olgar, Yusuf, Degirmenci, Sinan, Turan, Belma, Ozturk, Yusuf

“…Consumption of illicit pharmaceutical products containing sibutramine has been reported to cause cardiovascular toxicity problems. This study aimed to…”
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