Search Results - "Bellward, G D"

Effect of cimetidine on hepatic cytochrome P450: evidence for formation of a metabolite-intermediate complex by Levine, M, Bellward, G D

“…Cimetidine is an inhibitor of hepatic cytochrome P450 (CYP) in vivo and in vitro in both rats and humans. However, the concentrations of cimetidine required to…”
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Biological effects of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in bald eagle (Haliaeetus leucocephalus) chicks by Elliott, J.E. (Canadian Wildlife Service, Delta, British Columbia, Canada.), Norstrom, R.J, Lorenzen, A, Hart, L.E, Philbert, H

“…During the 1992 breeding season, eggs of bald eagles (Haliaeetus leucocephalus) were collected within a gradient of exposure to chlorinated hydrocarbon…”
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Growth hormone regulation and developmental expression of rat hepatic CYP3A18, CYP3A9, and CYP3A2 by Kawai, Masahiko, Bandiera, Stelvio M, Chang, Thomas K.H, Bellward, Gail D

“…The present study investigated the role of growth hormone (GH) in hepatic CYP3A18 and CYP3A9 expression in prepubertal and adult male rats. For comparison, the…”
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Selective inhibition of rat hepatic microsomal cytochrome P-450. II. Effect of the in vitro administration of cimetidine by Chang, T, Levine, M, Bellward, G D

“…The purpose of this study was to determine whether the differential inhibition of rat hepatic microsomal cytochrome P-450 in adult male rats by in vivo…”
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Selective inhibition of rat hepatic microsomal cytochrome P-450. I. Effect of the in vivo administration of cimetidine by Chang, T, Levine, M, Bandiera, S M, Bellward, G D

“…Cimetidine is considered to be a general inhibitor of cytochrome P-450 enzymes, but there is indirect evidence that certain cytochrome P-450 enzymes are not…”
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Effect of Androgen Administration During Puberty on Hepatic CYP2C11, CYP3A, and CYP2A1 Expression in Adult Female Rats by ANDERSON, M. D, BANDIERA, S. M, CHANG, T. K. H, BELLWARD, G. D

“…This biochemical and pharmacokinetic investigation was undertaken to evaluate the effects of androgen administration during puberty on sex-dependent cytochrome…”
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Induces Hepatic Cytochrome P450-Dependent Arachidonic Acid Epoxygenation in Diverse Avian Orders: Regioisomer Selectivity and Immunochemical Comparison of the TCDD-Induced P450s to CYP1A4 and 1A5 by Gilday, D., Bellward, G.D., Sanderson, J.T., Janz, D.M., Rifkind, A.B.

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) markedly induced cytochrome P450 (CYP)-dependent arachidonic acid metabolism in liver microsomes from hatchlings of…”
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In ovo 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in three avian species. 2. Effects on estrogen receptor and plasma sex steroid hormones during the perinatal period by JANZ, D. M, BELLWARD, G. D

“…As opposed to mammals, the heterogametic sex in birds is female, and sexual differentiation of the central nervous system away from the intrinsic male pattern…”
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Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat by Bellward, G D, Chang, T, Rodrigues, B, McNeill, J H, Maines, S, Ryan, D E, Levin, W, Thomas, P E

“…Hepatic microsomal cytochrome P-450j has been studied using the male spontaneously diabetic BB rat as a model for insulin-dependent diabetes. This approach…”
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Peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase: pretranslational regulation and impact on microsomal drug activation by Chang, T K, Bellward, G D

“…To characterize the dose response and time course of peripubertal testosterone imprinting of rat hepatic CYP2C11 and steroid 5 alpha-reductase and to gain…”
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Modulation of Hepatic CYP2A1, CYP2C11, and CYP3A9 Expression in Adult Rats by Neonatal Administration of Tamoxifen by KAWAI, M, BANDIERA, S. M, CHANG, T. K. H, POULET, F. M, VANCUTSEM, P. M, BELLWARD, G. D

“…To examine the effect of neonatal administration of tamoxifen on adult expression of hepatic cytochrome P-450 (CYP) enzymes and steroid 5α-reductase, male and…”
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Effects of acute 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on plasma thyroid and sex steroid hormone concentrations and estrogen receptor levels in adult great blue herons by Janz, David M., Bellward, Gail D.

“…Adult great blue herons (Ardea herodias) were exposed intraperitoneally to a single dose of 20 μg/kg body weight of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD)…”
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Effects of embryonic and adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic microsomal testosterone hydroxylase activities in great blue herons (Ardea herodias) by Sanderson, J. Thomas, Janz, David M., Bellward, Gail D., Giesy, John P.

“…In a continuing effort to evaluate biomarkers of exposure of great blue herons (Ardea herodias) to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) and related…”
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Effect of Ovariectomy and Androgen on Phenobarbital Induction of Hepatic CYP2B1 and CYP2B2 in Sprague-Dawley Rats by CHANG, T. K. H, ANDERSON, M. D, BANDIERA, S. M, BELLWARD, G. D

“…The purpose of this study was to investigate the impact of prepubertal ovariectomy and postpubertal administration of testosterone on inducibility of rat…”
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Endocrine mediation of psychosocial stressor effects on mouse mammary tumor growth by Rowse, G J, Weinberg, J, Bellward, G D, Emerman, J T

“…We have demonstrated that differential housing alters the growth rate of the androgen-responsive Shionogi mouse mammary carcinoma (SC115). In the present study…”
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Impact of tamoxifen on peripubertal Androgen imprinting of rat hepatic cytochrome P450 2C11, cytochrome P450 3A2, and steroid 5α-reductase by Chang, Thomas K.H., Chan, Maureen M.Y., Holsmer, Susan L., Bandiera, Stelvio M., Bellward, Gail D.

“…Expression of sex-dependent rat hepatic cytochromes P450 and steroid 5α-reductase is regulated mainly by the sex-specific pattern of growth hormone (GH)…”
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Hepatic microsomal ethoxyresorufin O-deethylase-inducing potency in ovo and cytosolic Ah receptor binding affinity of 2,3,7,8-tetrachlorodibenzo-p-dioxin : comparison of four avian species by SANDERSON, J. T, BELLWARD, G. D

“…The hepatic microsomal ethoxyresorufin O-deethylase (EROD)-inducing potency in ovo of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was determined in the domestic…”
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Comparison of polychlorinated dibenzodioxin levels with hepatic mixed-function oxidase induction in great blue herons by Bellward, G D, Norstrom, R J, Whitehead, P E, Elliott, J E, Bandiera, S M, Dworschak, C, Chang, T, Forbes, S, Cadario, B, Hart, L E

“…As part of the Canadian Wildlife Service monitoring of great blue herons in British Columbia, eggs were collected from three colonies with low, intermediate,…”
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Testosterone metabolism in rat liver cytosolic androgen binding assays by Sunahara, G I, Bellward, G D

“…Testosterone metabolism was studied in vitro, using incubation conditions similar to those employed in some adult male rat liver cytosolic androgen receptor…”
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Biological effects of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in double-crested cormorant chicks (Phalacrocorax auritus) by Sanderson, J T, Norstrom, R J, Elliott, J E, Hart, L E, Cheng, K M, Bellward, G D

“…The present project assessed the effect of environmental contamination with polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls…”
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