Bartonella vinsonii subsp. arupensis Immunodominant Surface Antigen BrpA Gene, Encoding a 382-Kilodalton Protein Composed of Repetitive Sequences, Is a Member of a Multigene Family Conserved among Bartonella Species

Bartonella proteins that elicit an antibody response during an infection are poorly defined; therefore, to characterize antigens recognized by the host, a Bartonella genomic expression library was screened with serum from an infected mouse. This process led to the discovery of a Bartonella vinsonii...

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Bibliographic Details
Published in:	Infection and Immunity Vol. 73; no. 5; pp. 3128 - 3136
Main Authors:	Gilmore, Robert D, Bellville, Travis M, Sviat, Steven L, Frace, Michael
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-05-2005
Subjects:	Amino Acid Sequence Animals Antigens, Bacterial - chemistry Antigens, Bacterial - genetics Antigens, Bacterial - immunology Antigens, Bacterial - metabolism Antigens, Surface - chemistry Antigens, Surface - genetics Antigens, Surface - immunology Antigens, Surface - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Proteins - metabolism Bartonella Bartonella - chemistry Bartonella - genetics Bartonella - immunology Bartonella - metabolism Bartonella henselae Bartonella Infections - immunology Bartonella Infections - microbiology Bartonella quintana Bartonella vinsonii Base Sequence Biological and medical sciences Blotting, Western Conserved Sequence Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Host Response and Inflammation Humans Immunodominant Epitopes - chemistry Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Immunodominant Epitopes - metabolism Mice Microbiology Molecular Sequence Data Multigene Family Repetitive Sequences, Nucleic Acid Sequence Analysis, DNA Antigen Gene Microbiology Multigene family Transposable element Immunodominance Immunity Aminoacid sequence IS element
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Summary:	Bartonella proteins that elicit an antibody response during an infection are poorly defined; therefore, to characterize antigens recognized by the host, a Bartonella genomic expression library was screened with serum from an infected mouse. This process led to the discovery of a Bartonella vinsonii subsp. arupensis gene encoding a 382-kDa protein, part of a gene family encoding large proteins, each containing multiple regions of repetitive segments. The genes were termed brpA to -C (bartonella repeat protein) and bore significant similarity to genes encoding the BadA adhesin protein and members of the variably expressed outer membrane protein family of proteins from Bartonella henselae and Bartonella quintana, respectively.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: Microbiology and Molecular Genetics Dept., University of Vermont, Burlington, VT 05405. Editor: V. J. DiRita Corresponding author. Mailing address: Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, P.O. Box 2087, Foothills Campus, Fort Collins, CO 80521. Phone: (970) 221 6405. Fax: (970) 221 6470. E-mail: rbg9@cdc.gov.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.73.5.3128-3136.2005