Search Results - "Bellve, Karl D"

Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant by Wu, Sijia, Bellve, Karl D., Fogarty, Kevin E., Melikian, Haley E.

“…The dopamine (DA) transporter (DAT) facilitates high-affinity presynaptic DA reuptake that temporally and spatially constrains DA neurotransmission. Aberrant…”
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Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes by Leonard, Deborah, Hayakawa, Akira, Lawe, Deirdre, Lambright, David, Bellve, Karl D, Standley, Clive, Lifshitz, Lawrence M, Fogarty, Kevin E, Corvera, Silvia

“…The biological function of receptors is determined by their appropriate trafficking through the endosomal pathway. Following internalization, the transferrin…”
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Insulin Stimulates Membrane Fusion and GLUT4 Accumulation in Clathrin Coats on Adipocyte Plasma Membranes by Huang, Shaohui, Lifshitz, Larry M., Jones, Christine, Bellve, Karl D., Standley, Clive, Fonseca, Sonya, Corvera, Silvia, Fogarty, Kevin E., Czech, Michael P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Visualization of self-delivering hydrophobically modified siRNA cellular internalization by Ly, Socheata, Navaroli, Deanna M., Didiot, Marie-Cécile, Cardia, James, Pandarinathan, Lakshmipathi, Alterman, Julia F., Fogarty, Kevin, Standley, Clive, Lifshitz, Lawrence M., Bellve, Karl D., Prot, Matthieu, Echeverria, Dimas, Corvera, Silvia, Khvorova, Anastasia

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Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype by De Crescenzo, Valerie, Fogarty, Kevin E, Lefkowitz, Jason J, Bellve, Karl D, Zvaritch, Elena, MacLennan, David H, Walsh, John V. Jr

“…The type 1 ryanodine receptor (RyR1) is expressed widely in the brain, with high levels in the cerebellum, hippocampus, and hypothalamus. We have shown that…”
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Dihydropyridine Receptors and Type 1 Ryanodine Receptors Constitute the Molecular Machinery for Voltage-Induced Ca2+ Release in Nerve Terminals by De Crescenzo, Valerie, Fogarty, Kevin E, ZhuGe, Ronghua, Tuft, Richard A, Lifshitz, Lawrence M, Carmichael, Jeffrey, Bellve, Karl D, Baker, Stephen P, Zissimopoulos, S, Lai, F. Anthony, Lemos, Jose R, Walsh, John V., Jr

“…Ca2+ stores were studied in a preparation of freshly dissociated terminals from hypothalamic magnocellular neurons. Depolarization from a holding level of -80…”
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Plasma Membrane Domains Specialized for Clathrin-mediated Endocytosis in Primary Cells by Bellve, Karl D., Leonard, Deborah, Standley, Clive, Lifshitz, Lawrence M., Tuft, Richard A., Hayakawa, Akira, Corvera, Silvia, Fogarty, Kevin E.

“…Clathrin assembly at the plasma membrane is a fundamental process required for endocytosis. In cultured cells, most of the clathrin is localized to large…”
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Visualization of self-delivering hydrophobically modified siRNA cellular internalization by Ly, Socheata, Navaroli, Deanna M, Didiot, Marie-Cécile, Cardia, James, Pandarinathan, Lakshmipathi, Alterman, Julia F, Fogarty, Kevin, Standley, Clive, Lifshitz, Lawrence M, Bellve, Karl D, Prot, Matthieu, Echeverria, Dimas, Corvera, Silvia, Khvorova, Anastasia

“…siRNAs are a new class of therapeutic modalities with promising clinical efficacy that requires modification or formulation for delivery to the tissue and cell…”
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Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton by Gabriel, Luke R, Wu, Sijia, Kearney, Patrick, Bellvé, Karl D, Standley, Clive, Fogarty, Kevin E, Melikian, Haley E

“…Dopaminergic signaling profoundly impacts rewarding behaviors, movement, and executive function. The presynaptic dopamine (DA) transporter (DAT) recaptures…”
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NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone by Awata, Junya, Takada, Saeko, Standley, Clive, Lechtreck, Karl F, Bellvé, Karl D, Pazour, Gregory J, Fogarty, Kevin E, Witman, George B

“…The protein nephrocystin-4 (NPHP4) is widespread in ciliated organisms, and defects in NPHP4 cause nephronophthisis and blindness in humans. To learn more…”
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Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus by Rojas-Rodriguez, Raziel, Lifshitz, Lawrence M., Bellve, Karl D., Min, So Yun, Pires, Jacqueline, Leung, Katherine, Boeras, Crina, Sert, Aylin, Draper, Jacqueline T., Corvera, Silvia, Moore Simas, Tiffany A.

“…Aims/hypothesis During pregnancy, adipose tissue (AT) must expand to support the growing fetus and the future nutritional needs of the offspring. Limited…”
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Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis by Navaroli, Deanna M, Bellvé, Karl D, Standley, Clive, Lifshitz, Lawrence M, Cardia, James, Lambright, David, Leonard, Deborah, Fogarty, Kevin E, Corvera, Silvia

“…Cell surface receptors and other proteins internalize through diverse mechanisms at the plasma membrane and are sorted to different destinations. Different…”
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Catecholamine exocytosis during low frequency stimulation in mouse adrenal chromaffin cells is primarily asynchronous and controlled by the novel mechanism of Ca2+ syntilla suppression by Lefkowitz, Jason J., DeCrescenzo, Valerie, Duan, Kailai, Bellve, Karl D., Fogarty, Kevin E., Walsh, John V., ZhuGe, Ronghua

“…Key points Although the importance of asynchronous exocytosis is becoming clearer, not enough is known about its roles and mechanisms. Here we describe the…”
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Adipose tissue angiogenesis assay by Rojas-Rodriguez, Raziel, Gealekman, Olga, Kruse, Maxwell E, Rosenthal, Brittany, Rao, Kishore, Min, Soyun, Bellve, Karl D, Lifshitz, Lawrence M, Corvera, Silvia

“…Changes in adipose tissue mass must be accompanied by parallel changes in microcirculation. Investigating the mechanisms that regulate adipose tissue…”
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Suppression of Ca2+ syntillas increases spontaneous exocytosis in mouse adrenal chromaffin cells by Lefkowitz, Jason J, Fogarty, Kevin E, Lifshitz, Lawrence M, Bellve, Karl D, Tuft, Richard A, ZhuGe, Ronghua, Walsh, Jr, John V, De Crescenzo, Valerie

“…A central concept in the physiology of neurosecretion is that a rise in cytosolic [Ca(2+)] in the vicinity of plasmalemmal Ca(2+) channels due to Ca(2+) influx…”
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Nephrocystin-4 controls ciliary trafficking of membrane and large soluble proteins at the transition zone by Awata, Junya, Takada, Saeko, Standley, Clive, Lechtreck, Karl F., Bellvé, Karl D., Pazour, Gregory J., Fogarty, Kevin E., Witman, George B.

“…The protein nephrocystin-4 (NPHP4) is widespread in ciliated organisms, and defects in NPHP4 cause nephronophthisis and blindness in humans. To learn more…”
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Catecholamine exocytosis during low frequency stimulation in mouse adrenal chromaffin cells is primarily asynchronous and controlled by the novel mechanism of Ca 2+ syntilla suppression by Lefkowitz, Jason J., DeCrescenzo, Valerie, Duan, Kailai, Bellve, Karl D., Fogarty, Kevin E., Walsh, John V., ZhuGe, Ronghua

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Total Internal Reflection Fluorescence Microscopy Reveals Insulin RegulatiOn of GluT4 Vesicular Trafficking near the Plasma Membrane of 3T3-L1 Adipocyte by Huang, Shaohui, Fonseca, Sonya, stanley, Clive, Bellve, Karl D

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Suppression of Ca^sup 2+^ syntillas increases spontaneous exocytosis in mouse adrenal chromaffin cells by Lefkowitz, Jason J, Fogarty, Kevin E, Lifshitz, Lawrence M, Bellve, Karl D, Tuft, Richard A, ZhuGe, Ronghua, Walsh, John V, De Crescenzo, Valerie

“…A central concept in the physiology of neurosecretion is that a rise in cytosolic [Ca...] in the vicinity of plasmalemmal Ca... channels due to Ca... influx…”
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Beclin 1 regulates growth factor receptor signaling in breast cancer by Rohatgi, R A, Janusis, J, Leonard, D, Bellvé, K D, Fogarty, K E, Baehrecke, E H, Corvera, S, Shaw, L M

“…Beclin 1 is a haploinsufficient tumor suppressor that is decreased in many human tumors. The function of beclin 1 in cancer has been attributed primarily to…”
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